Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 CausalMutation CGI

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 CausalMutation CLINVAR

Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.460 CausalMutation CLINVAR

Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.460 CausalMutation CGI

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.390 GeneticVariation UNIPROT

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.350 CausalMutation CGI

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.330 CausalMutation CGI

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.020 Biomarker BEFREE Two of the major protein species (gp88 and gp130) were common to all four cell lines used (HeLa-cervical carcinoma, T47D-breast carcinoma, and HMB2 and SK1477-two melanoma cell lines). 6093357

1984

Entrez Id: 4827
Gene Symbol: NM
NM
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.010 Biomarker BEFREE Two of the major protein species (gp88 and gp130) were common to all four cell lines used (HeLa-cervical carcinoma, T47D-breast carcinoma, and HMB2 and SK1477-two melanoma cell lines). 6093357

1984

Entrez Id: 3572
Gene Symbol: IL6ST
IL6ST
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.010 Biomarker BEFREE Two of the major protein species (gp88 and gp130) were common to all four cell lines used (HeLa-cervical carcinoma, T47D-breast carcinoma, and HMB2 and SK1477-two melanoma cell lines). 6093357

1984

Entrez Id: 10128
Gene Symbol: LRPPRC
LRPPRC
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.010 Biomarker BEFREE Two of the major protein species (gp88 and gp130) were common to all four cell lines used (HeLa-cervical carcinoma, T47D-breast carcinoma, and HMB2 and SK1477-two melanoma cell lines). 6093357

1984

Entrez Id: 3930
Gene Symbol: LBR
LBR
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.010 Biomarker BEFREE It was concluded that the presence of carcinoma of the uterine cervix in human females has no bearing either on spontaneous and MMC-induced SCE rates or on cell cycle progression in PHA-stimulated cultures of peripheral blood lymphocytes. 3917367

1985

Entrez Id: 64218
Gene Symbol: SEMA4A
SEMA4A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.010 AlteredExpression BEFREE To examine the correlations between ras oncogene expression and the development of cervical cancer, the authors studied the reactivity of cervical intraepithelial neoplasia (CIN) and microinvasive lesions of the human uterine cervix by using anti-ras p21 mouse monoclonal antibody rp35. 2196111

1990

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 AlteredExpression BEFREE Expression of RB and p53 proteins in HPV-positive and HPV-negative cervical carcinoma cell lines. 1648361

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 Biomarker BEFREE Our data suggest that loss of wild-type p53 function is important in development of cervical carcinoma, and that this might be achieved either by mutation within the p53 gene or the presence of a virally encoded p53 binding protein. 1646990

1991

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE Although a high incidence of HPV DNA integration and a low incidence of p53 mutation were confirmed in cancer of the uterine cervix, there was no inverse association between integration of HPV types 16 and/or 18 DNA and p53 mutation. 1336492

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 Biomarker BEFREE The inactivation of the wild-type p53 function resulting from a missense mutation, or the lack of detectable wild-type p53 protein due to the translational/post-translational deregulation of p53 protein levels may be the contributing factor in the tumorigenicity of these five cases of cervical cancer. 1322252

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE Alterations of the p53 gene in human primary cervical carcinoma with and without human papillomavirus infection. 1327506

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 Biomarker BEFREE Our data indicate that loss of wild-type p53 function is important in the pathology of cervical cancer and that in the absence of an HPV-encoded gene product that mediates loss of p53 function, somatic mutation of the gene is required. 1349102

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 Biomarker BEFREE Inactivation of the protein product of the wild-type tumour suppressor gene p53 through complexing of the protein with the E6 oncoprotein of human papillomaviruses (HPV) in HPV-infected cells is thought to be important in the aetiology of cervical carcinoma. 1352566

1992

Entrez Id: 5894
Gene Symbol: RAF1
RAF1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.030 GeneticVariation BEFREE Loss of heterozygosity (LOH) was found in 10 out of 12 informative cases with CaCx at RAF-1 locus (3p25) and in 10 out of 11 cases at D3S3 (3p14). 1359830

1992

Entrez Id: 6037
Gene Symbol: RNASE3
RNASE3
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.020 GeneticVariation BEFREE Loss of heterozygosity (LOH) was found in 10 out of 12 informative cases with CaCx at RAF-1 locus (3p25) and in 10 out of 11 cases at D3S3 (3p14). 1359830

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 AlteredExpression BEFREE Inactivation of p53 function is important in the pathogenesis of cervical carcinoma. 8393371

1993

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE The p53 mutation at codon 273 has been previously reported in one of the HPV-negative cervical carcinoma cell line (C33A). 1363512

1993

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE It appears that p53 and Rb mutations are a very rare event in cervical cancer and their occurrence is apparently not strictly correlated with HPV status. 8384745

1993