Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 CausalMutation CGI

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 CausalMutation CLINVAR

Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.460 CausalMutation CLINVAR

Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.460 CausalMutation CGI

Entrez Id: 6794
Gene Symbol: STK11
STK11
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.390 GeneticVariation UNIPROT

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.350 CausalMutation CGI

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.330 CausalMutation CGI

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.350 GeneticVariation BEFREE "Low-risk" and "high-risk" HPV-infection and K-ras gene point mutations in human cervical cancer: a study of 31 cases. 11569923

2001

Entrez Id: 5133
Gene Symbol: PDCD1
PDCD1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.030 Biomarker BEFREE <b>Areas covered</b>: Here we report the pharmacologic properties, clinical efficacy, and safety profile of pembrolizumab, an IgG4-kappa humanized monoclonal antibody against the programmed cell death protein 1 (PD-1) receptor, for the treatment of cervical cancer. 31322926

2019

Entrez Id: 7468
Gene Symbol: NSD2
NSD2
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.030 Biomarker BEFREE <b>Conclusion:</b> WHSC1 may be a poor prognostic indicator of cervical cancer and a potential novel therapeutic target for the same. 31354300

2019

Entrez Id: 407004
Gene Symbol: MIR22
MIR22
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.040 Biomarker BEFREE <b>Conclusion:</b> Taken together, our data provide primary proof that miR-22-3p can induce cervical cancer cell growth at least in part by up-regulating its expression to decrease eIF4EBP3 expression levels; miR-22-3p thus holds promise as a prognostic biomarker and potential therapeutic target for treating cervical cancer. 29333098

2018

Entrez Id: 8637
Gene Symbol: EIF4EBP3
EIF4EBP3
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.010 Biomarker BEFREE <b>Conclusion:</b> Taken together, our data provide primary proof that miR-22-3p can induce cervical cancer cell growth at least in part by up-regulating its expression to decrease eIF4EBP3 expression levels; miR-22-3p thus holds promise as a prognostic biomarker and potential therapeutic target for treating cervical cancer. 29333098

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE <b>Conclusion:</b> This study indicates that <i>KLF4</i> and <i>ESR1</i> are downregulated by the upregulated miR21 and miRNA16 in cervical cancer, respectively, using bioinformatics analysis, and the lower expression of <i>KLF4</i> and <i>ESR1</i> is closely related to the poor prognosis. 31354287

2019

Entrez Id: 407021
Gene Symbol: MIR29A
MIR29A
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.040 Biomarker BEFREE <b>Conclusion:</b> MiR-29a-DNMT1-SOCS1 axis plays an important role on invasion and metastasis in cervical cancer via NF-κB signaling pathway. 31038361

2019

Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.080 Biomarker BEFREE <b>Conclusion:</b> MiR-29a-DNMT1-SOCS1 axis plays an important role on invasion and metastasis in cervical cancer via NF-κB signaling pathway. 31038361

2019

Entrez Id: 8651
Gene Symbol: SOCS1
SOCS1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.080 Biomarker BEFREE <b>Conclusion:</b> MiR-29a-DNMT1-SOCS1 axis plays an important role on invasion and metastasis in cervical cancer via NF-κB signaling pathway. 31038361

2019

Entrez Id: 3082
Gene Symbol: HGF
HGF
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.050 Biomarker BEFREE <b>Conclusion:</b> Our study demonstrated verticillin A inhibits the migration ability of human gastric cancer (AGS) cells and cervical cancer (HeLa) cells by targeting c-Met and its downstream FAK/Src signaling pathways, and suggested that verticillin A acts as a novel HGF/c-Met inhibitor by reducing expression of this receptor. 31440058

2019

Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE <b>Methods:</b> A total number of 42 patients who were treated for cervical squamous cell carcinoma and had underwent <sup>18</sup>F-FDG PET/CT for suspected recurrence of cervical cancer were retrospectively reviewed in this study and their clinical, pathological and serological data were collected and analyzed. 30210633

2018

Entrez Id: 885
Gene Symbol: CCK
CCK
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.070 Biomarker BEFREE <b>Methods:</b> To detect the effect of SFA gels and its active ingredients, CCK-8 assay and colony assay were used on cervical cancer cells proliferation. 29721044

2018

Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation BEFREE <b>Objective:</b> Previous studies have reported that Ile462Val polymorphism in the gene Cytochrome P450 1A1 (<i>CYP1A1</i>) is associated with the risk of cervical cancer, but inconsistent results have emerged. 29326607

2017

Entrez Id: 407041
Gene Symbol: MIR34B
MIR34B
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.030 AlteredExpression BEFREE <b>Results:</b> Here, we found expression of miR-34b to be downregulated in cervical cancer in comparison with the adjacent normal tissues. 31119955

2019

Entrez Id: 81848
Gene Symbol: SPRY4
SPRY4
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.010 AlteredExpression BEFREE <i>SPRY4-IT1</i> was up-regulated in CC cell lines. 31092700

2019

Entrez Id: 7161
Gene Symbol: TP73
TP73
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.090 AlteredExpression BEFREE <i>In silico</i> analysis revealed that the expression of TP73 in cervical cancer tissue is higher than it in corresponding normal tissue, as well as in cervical cancer. 30420492

2018

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 Biomarker BEFREE <i>Synuclein-γ</i> inhibition reduced cervical cancer tumor growth through the AKT pathway. 31333726

2019

Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.100 GeneticVariation BEFREE (2) rs1048943 (CYP1A1 A4889G) showed the strongest association with cervical cancer in the allele effect model (1.83[1.57, 2.13]); in addition, rs1048943 (CYP1A1 A4889G) had a very strong association in the dominant and recessive effect model. 25928231

2015