Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE The p53 polymorphism itself may not be a risk factor for cervical cancer in Northeastern Thailand. 15183536

2004

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE Here we analyse pooled data from 49 studies to determine whether there is an association between TP53 codon 72 polymorphism and cervical cancer. 19625214

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE Presence and persistence of HPV infection and p53 mutation in cancer of the cervix uteri and the vulva. 7591279

1995

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE The p21 arginine allele was significantly associated with CaCx in the p53 proline non-homozygous group of subjects (OR(age-adjusted) = 2.68; 95% CI: 1.21-5.91; P = 0.01), and specifically in the p53 heterozygous group (OR(age-adjusted) = 2.91; 95% CI = 1.12-7.56; P = 0.03). 16054204

2005

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE We found no increased risk of developing cervical cancer in respect to p53 polymorphism, independent of histological diagnosis. 11072671

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE It may be assumed that the low incidence of cervical cancer in Israeli Jewish women and the differences between the ethnic groups may be related to the frequency pattern of the homozygous arginine p53 polymorphism 12445252

2003

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE These data suggest that there are significant associations between the miR-502-binding site SNP in the 3'-UTR of SET8 and the TP53 codon 72 polymorphism with cervical cancer in Chinese, and there is a gene-gene interaction. 25169478

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE Recently, it has been demonstrated that the presence of homozygous arginine at codon 72 renders p53 about seven times more susceptible to E6-mediated proteolytic degradation as well as to cervical cancer than those with proline homozygotes or proline/arginine heterozygotes. 14577584

2003

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE To confirm this result we examined the proportion of p53 genotypes in a larger number of patients with cervical cancer and in patients with squamous intraepithelial lesions (SIL) compared to a control population. 10472360

1999

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE We investigated the distribution of p53 codon 72 polymorphism in cervical cancer patients and a control group of healthy women from Poland. 11996107

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE Thus, polymorphism of the p53 itself as well as in combination with HPV infection may not be a genetic risk for cervical cancer and therefore much attention should be paid to other risk factors such as sexual behavior and smoking. 19771536

2010

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE Ethnic variation of the P53 codon 72 polymorphism, HPV persistence, and cervical cancer risk. 14678586

2003

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE Although genetic variation in TP53 might affect the natural history of HPV and cervical cancer, further work is needed to elucidate the possible mechanism. 19423538

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE Although a high incidence of HPV DNA integration and a low incidence of p53 mutation were confirmed in cancer of the uterine cervix, there was no inverse association between integration of HPV types 16 and/or 18 DNA and p53 mutation. 1336492

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE Although the p53 arginine allele is itself an important risk factor for cervical cancer, the combined risk with LOH of Rb, which appears to be greater, might indicate a possible epistatic effect of the two genes/polymorphisms. 22692183

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE This cell line is useful for studying the carcinogenesis of cervical carcinoma and for investigating the biological characteristics of a HPV-negative and mutated p53 squamous cell carcinoma of the uterine cervix. 9790785

1998

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE This suggests that, in p53 Arg/Arg women, infection with HPV-16 350T variants confers a higher risk of cervical cancer. 10644829

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE The p53 codon 72 polymorphism is unlikely to be related to HPV status and the onset of cervical cancer. 15721419

2005

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE The Arg>Pro polymorphism in codon 72 of p53 gene is known to affect the susceptibility of cervical cancer differently in different population worldwide although information regarding its role in determining survival status and disease outcome in patients is lacking. 28139534

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE There is no significant correlation between p53 polymorphism and development of cervical cancer. 16681751

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE The genotype combination of p53 and GST played a more important role in describing the relative risk of cervical carcinoma. 10813720

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE These results cannot rule out an association between TP53 polymorphism at codon 72, HPV infection and the etiology of cervical cancer in this population sample. 14756543

2004

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE To study the molecular abnormalities involved in the multistage development of cervical carcinoma (CC), we investigated the presence of oncogenic human papillomavirus (HPV) sequences, loss of heterozygosity (LOH), and microsatellite alterations at several genes/loci at 3p (3p14.2 at the FHIT gene, 3p14.3-21.1, 3p21, and 3p22-24.2), 9p21, RB and P53, and P53 gene point mutations in precisely microdissected archival tissues from 20 CCs and their accompanying precursor lesions (cervical intraepithelial neoplasia, CIN; n = 40) and normal epithelia (n = 20). 9242443

1997

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE Alterations of the p53 gene in human primary cervical carcinoma with and without human papillomavirus infection. 1327506

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE We examined host p53 codon 72 genotype frequencies and found that patients with cervical abnormalities and women with HPV16 and HPV18 infections had a lower genotype frequency of the homozygous (AA) previously reported to be associated with cervical cancer, than uninfected women with no abnormalities. 16121365

2005