Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 SusceptibilityMutation ORPHANET

Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.080 Biomarker BEFREE Association between phosphoglucomutase (PGM1) and group-specific component (Gc) subtypes and tuberculosis. 6224013

1983

Entrez Id: 5236
Gene Symbol: PGM1
PGM1
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.020 Biomarker BEFREE For the Gc system, the phenotypic frequencies did not differ significantly, but the PGM1 system showed a significant difference in the tuberculosis patients compared to controls. 6224013

1983

Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE We demonstrate here that human T cells from healthy individuals and disease sites are able to recognize determinants within the 65 kD protein that are either specific for M. tuberculosis or are conserved between GroEL of mycobacterial, E. coli or human origin. 2476144

1989

Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 AlteredExpression BEFREE We studied monocytes from patients with tuberculosis and healthy skin test reactive controls for expression and function of IL 2 receptors (IL 2R). 2347912

1990

Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE To further study this aspect, we stimulated T cells from normal human blood donors with synthetic peptides (each of approximately 15 amino acids in length) from the heat shock protein 65 of Mycobacterium tuberculosis-M. bovis. 1693134

1990

Entrez Id: 100
Gene Symbol: ADA
ADA
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 AlteredExpression BEFREE Non specific indicators of tuberculosis are generally unhelpful although the bromide partition test and assay of the enzyme adenosine deaminase in cerebrospinal fluid appear to be of value in the diagnosis of tuberculous meningitis. 2128831

1991

Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.080 Biomarker BEFREE Cytofluorometric analysis of the expressed gamma delta TCR repertoire of M. tuberculosis expanded cells was performed using anti-V region antibodies. 1658146

1991

Entrez Id: 7303
Gene Symbol: TYS
TYS
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.030 Biomarker BEFREE Cytogenetic effects of 4 common anti-tubercular drugs, isoniazid (H), streptomycin (S), rifampicin (R) and pyrazinamide (Z), in 3 different combinations (2 SHRZ, 2 HRZ and 2 H2R2Z2) were evaluated in the lymphocytes of tuberculosis patients undergoing chemotherapy, in order to estimate their mutagenic potential in combination. 1988820

1991

Entrez Id: 56916
Gene Symbol: SMARCAD1
SMARCAD1
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.030 Biomarker BEFREE Cytogenetic effects of 4 common anti-tubercular drugs, isoniazid (H), streptomycin (S), rifampicin (R) and pyrazinamide (Z), in 3 different combinations (2 SHRZ, 2 HRZ and 2 H2R2Z2) were evaluated in the lymphocytes of tuberculosis patients undergoing chemotherapy, in order to estimate their mutagenic potential in combination. 1988820

1991

Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE We used two PCR reactions: in the first the complex-specific insertion sequence IS986/IS6110 was used to specifically detect DNA from Mycobacterium tuberculosis complex bacteria; in the second, conserved sequences of the mycobacterial groEL gene were used to detect DNA from mycobacteria other than M tuberculosis. 1349051

1992

Entrez Id: 4069
Gene Symbol: LYZ
LYZ
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.030 Biomarker BEFREE We conclude that DNA amplification in combination with lysozyme lysis can be used routinely in clinical laboratories as a rapid and sensitive test for the diagnosis of tuberculosis. 1515757

1992

Entrez Id: 6299
Gene Symbol: SALL1
SALL1
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.010 Biomarker BEFREE A Sal I-Hin dIII restriction fragment from Mycobacterium tuberculosis was found to hybridize specifically with genomic DNA from M. tuberculosis. 1383698

1992

Entrez Id: 847
Gene Symbol: CAT
CAT
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Catalase-peroxidase gene sequences in isoniazid-sensitive and -resistant strains of Mycobacterium tuberculosis from New York City. 8376822

1993

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE The granulomatous immune response in tuberculosis is characterized by delayed hypersensitivity and is mediated by various cytokines released by the stimulated mononuclear phagocytes, including tumor necrosis factor-alpha (TNF alpha) and IL-1 beta. 7683696

1993

Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Limiting dilution analysis of IL-2-responsive cells in PBMC revealed that tuberculosis patients had 10-fold fewer IL-2-responsive cells than did controls. 8376820

1993

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 AlteredExpression BEFREE M. tuberculosis and its components upregulated IL-1 beta and TNF alpha mRNAs in THP-1 cells. 7683696

1993

Entrez Id: 929
Gene Symbol: CD14
CD14
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE M. tuberculosis cell wall component LAM acts similarly to LPS in activating mononuclear phagocyte cytokine TNF alpha and IL-1 beta release through CD14 and synthesis at the transcriptional level; both cytokines are key participants in the host immune response to tuberculosis. 7683696

1993

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 AlteredExpression BEFREE We demonstrated that the Mycobacterium tuberculosis cell wall component lipoarabinomannan (LAM) is a very potent inducer of IL-1 beta gene expression in human monocytes and investigated the mechanism of this effect. 7684503

1993

Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.600 GeneticVariation BEFREE This finding, together with the emerging information on almost total sequence homology between the murine and human Nramp genes suggests that this gene may be responsible for the phenotype of resistance or susceptibility to tuberculosis. 7713559

1994

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 AlteredExpression BEFREE When samples from patients with tuberculosis and control subjects were compared, there was a significant increase in numbers of IFN-gamma mRNA-positive BAL cells per 1,000 among patients with tuberculosis (p < 0.01). 8143065

1994

Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation BEFREE To create such complexes experimentally, we transfected an HLA-B27 cell line with the Mycobacterium tuberculosis hsp60 gene. 7905462

1994

Entrez Id: 4153
Gene Symbol: MBL2
MBL2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Functional studies revealed that M. leprae and M. tuberculosis sonicates bind MBP as strongly as pure mannan. 9098426

1994

Entrez Id: 51182
Gene Symbol: HSPA14
HSPA14
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.050 GeneticVariation BEFREE To create such complexes experimentally, we transfected an HLA-B27 cell line with the Mycobacterium tuberculosis hsp60 gene. 7905462

1994

Entrez Id: 100188784
Gene Symbol: AFA1
AFA1
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.020 Biomarker BEFREE A 240 bp region (nts 460-700) from the MPB 64 protein coding gene specific for Mycobacterium tuberculosis (TB) was selected for amplification.Nineteen clinical samples were studied. 7899891

1994