We found that the rs10911362 variants were associated with a decreased TB risk in this population (odds ratio [OR<sub>G</sub>] = 0.83 [0.72-0.95], OR<sub>add</sub> = 0.83 [0.72-0.95], OR<sub>dom</sub> = 0.78 [0.66-0.93], <i>p</i> < 0.05). rs10911362 might fall in a transcriptional factor binding site associated with ZNF410 and may be the expression quantitative trait loci (eQTL) for the SMG7 gene according to the Ensembl data.
Now in the present study, we investigated the immunotherapeutic effect of N-terminally formylated internal peptide 'f-MLLLPD' of mycobacterial glutamine synthetase (Rv2220) in mouse model of tuberculosis.
In our study, we aimed at investigating the association of polymorphisms in neutrophil cytosolic factor 2 (<i>NCF2</i>) gene, the core component of NADPHO, with susceptibility of TB in the Western Chinese Han population.
Polymorphisms in PYHIN1-IFI16-AIM2 rs1633256, rs1101998 and in IRF7 rs11246213 were associated with altered susceptibility to Mtb infection in this Brazilian cohort.
Although PD-1<sup>high</sup> CXCR5<sup>-</sup> MAIT cells from tuberculous pleural effusions had reduced IFN-γ level and increased expression of Tim-3 and GITR, they showed activated phenotype and had higher glucose uptake and lipid content.
Furthermore, the existence of five hypermethylated candidate genes (esxC, fabG3, fbpB, papA1 and pks2) in PAS-resistant M. tuberculosis H37Rv was verified using protein-protein interaction analysis in the STRING database.
Hepatocyte growth factor enhances the clearance of a multidrug-resistant Mycobacterium tuberculosis strain by high doses of conventional chemotherapy, preserving liver function.
In this study, we screened 87 overlapping synthetic peptides encoded by five RD2 proteins for diagnosing tuberculosis epitopes in 50 active tuberculosis (TB) cases, 31 non-tuberculosis patients and 36 healthy individuals.
In our study, we aimed at investigating the association of polymorphisms in neutrophil cytosolic factor 2 (<i>NCF2</i>) gene, the core component of NADPHO, with susceptibility of TB in the Western Chinese Han population.
In a previously published HIV negative South African casecontrol study of patients with asymptomatic Mycobacterium tuberculosis infection, a novel three-gene transcriptional signature comprising BATF2, GBP5 and SCARF1 achieved a positive predictive value (PPV) of 23% for progression to active TB within 90 days.
Taken together, our results suggest that miR-18a is up-regulated in macrophages response to Mtb infection, and it promotes intracellular Mtb survival through repressing autophagic process by down-regulation of ATM pathway.
In our study, we aimed at investigating the association of polymorphisms in neutrophil cytosolic factor 2 (<i>NCF2</i>) gene, the core component of NADPHO, with susceptibility of TB in the Western Chinese Han population.
Activating transcription factor 3 modulates the macrophage immune response to Mycobacterium tuberculosis infection via reciprocal regulation of inflammatory genes and lipid body formation.
Polymorphisms in PYHIN1-IFI16-AIM2 rs1633256, rs1101998 and in IRF7 rs11246213 were associated with altered susceptibility to Mtb infection in this Brazilian cohort.
Taken together, our results suggest that miR-18a is up-regulated in macrophages response to Mtb infection, and it promotes intracellular Mtb survival through repressing autophagic process by down-regulation of ATM pathway.
This study aimed to explore the influence of single nucleotide polymorphisms (SNPs) in Bradykinin receptor B2 (BDKRB2), Teneurin transmembrane protein 2 (TENM2), transforming growth factor beta 2 (TGFB2), and solute carrier family 2 member 13 (SLC2A13) on the risk of ATDILI.The subjects comprised 746 Chinese tuberculosis (TB) patients.
We investigated whether six genetic variants previously associated with LTL (TERC (rs10936599), TERT (rs2736100), NAF1 (7675998), OBFC1 (rs9420907), ZNF208 (rs8105767), and RTEL1 (rs755017)) are correlated with telomere length (TL) in peripheral blood mononuclear cells (PBMCs) in a cohort of Africans living with and without HIV and undergoing evaluation for tuberculosis (TB).
The identified sputum protein signature is a promising panel to differentiate ATB from NTB groups and suggest a deregulated DBP-AMP axis in lungs of tuberculosis patients.
The genes encoding TLR5, TNFSF10/TRAIL, PPP1R16B/TIMAP, SIAH1, PIK3IP1, and IL17RA were among the genes that were most significantly deregulated in TB and RA.