Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2875
Gene Symbol: GPT
GPT
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Nephrotoxic and hepatotoxic effects of triclosan and chlorhexidine in rats. 145039

1977

Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
Chemical and Drug Induced Liver Injury
0.300 Biomarker CTD_human A phase I study of recombinant human interferon-alpha 2a or human lymphoblastoid interferon-alpha n1 and concomitant zidovudine in patients with AIDS-related Kaposi's sarcoma. 1670585

1991

Entrez Id: 7124
Gene Symbol: TNF
TNF
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385

1995

Entrez Id: 7124
Gene Symbol: TNF
TNF
Chemical and Drug Induced Liver Injury
0.500 Therapeutic CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385

1995

Entrez Id: 3569
Gene Symbol: IL6
IL6
Chemical and Drug Induced Liver Injury
0.300 Therapeutic CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385

1995

Entrez Id: 3552
Gene Symbol: IL1A
IL1A
Chemical and Drug Induced Liver Injury
0.300 Therapeutic CTD_human The effect of interleukin 1 alpha on acetaminophen-induced hepatotoxicity. 8218930

1993

Entrez Id: 7124
Gene Symbol: TNF
TNF
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. 9696492

1998

Entrez Id: 7124
Gene Symbol: TNF
TNF
Chemical and Drug Induced Liver Injury
0.500 Therapeutic CTD_human Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. 9696492

1998

Entrez Id: 3589
Gene Symbol: IL11
IL11
Chemical and Drug Induced Liver Injury
0.300 Therapeutic CTD_human Protective effect of rhIL-11 in a murine model of acetaminophen-induced hepatotoxicity. 11421492

2001

Entrez Id: 6649
Gene Symbol: SOD3
SOD3
Chemical and Drug Induced Liver Injury
0.300 Therapeutic CTD_human EC-SOD gene therapy reduces paracetamol-induced liver damage in mice. 11529661

2002

Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
Chemical and Drug Induced Liver Injury
0.300 Therapeutic CTD_human IFN-gamma-inducible protein-10 (CXCL10) is hepatoprotective during acute liver injury through the induction of CXCR2 on hepatocytes. 11739529

2001

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Chemical and Drug Induced Liver Injury
0.300 Therapeutic CTD_human A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. 11743745

2001

Entrez Id: 10
Gene Symbol: NAT2
NAT2
Chemical and Drug Induced Liver Injury
0.300 Biomarker CTD_human Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis. 11915035

2002

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Chemical and Drug Induced Liver Injury
0.300 Biomarker CTD_human A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury. 12153990

2002

Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis. 12668988

2003

Entrez Id: 6652
Gene Symbol: SORD
SORD
Chemical and Drug Induced Liver Injury
0.300 Biomarker CTD_human Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity. 12763371

2003

Entrez Id: 9971
Gene Symbol: NR1H4
NR1H4
Chemical and Drug Induced Liver Injury
0.500 Biomarker CTD_human [Functional analysis of drug metabolizing enzymes using gene knockout animals]. 12875239

2003

Entrez Id: 1557
Gene Symbol: CYP2C19
CYP2C19
Chemical and Drug Induced Liver Injury
0.300 Biomarker CTD_human Association of troglitazone-induced liver injury with mutation of the cytochrome P450 2C19 gene. 12963435

2003

Entrez Id: 9970
Gene Symbol: NR1I3
NR1I3
Chemical and Drug Induced Liver Injury
0.300 Biomarker CTD_human A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. 14742670

2004

Entrez Id: 9970
Gene Symbol: NR1I3
NR1I3
Chemical and Drug Induced Liver Injury
0.300 Therapeutic CTD_human A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. 14742670

2004

Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9
Chemical and Drug Induced Liver Injury
0.300 Biomarker CTD_human Leflunomide-induced acute hepatitis. 14971821

2004

Entrez Id: 50616
Gene Symbol: IL22
IL22
Chemical and Drug Induced Liver Injury
0.300 Therapeutic CTD_human Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. 15122762

2004

Entrez Id: 686
Gene Symbol: BTD
BTD
Chemical and Drug Induced Liver Injury
0.300 Biomarker CTD_human Increased plasma biotinidase activity in rats with paracetamol-induced acute liver injury. 15469856

2004

Entrez Id: 3569
Gene Symbol: IL6
IL6
Chemical and Drug Induced Liver Injury
0.300 Therapeutic CTD_human Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. 15763341

2005

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
Chemical and Drug Induced Liver Injury
0.300 Biomarker CTD_human Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. 15763341

2005