Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Numerous studies have indicated that the neuropeptides including ghrelin, neurotensin, pituitary adenylate cyclase-activating polypeptide (PACAP), neuropeptide Y, substance P and orexin are closely related to the pathophysiology of Alzheimer's disease. 30687008

2018

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Copper Binding Induces Nitration of NPY under Nitrative Stress: Complicating the Role of NPY in Alzheimer's Disease. 30079723

2018

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression BEFREE Somatostatin (SOM) and Neuropeptide Y (NPY) are two neuropeptides which are expressed in GABAergic interneurons with different fates in AD the former only being markedly affected. 30327597

2018

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Recently, it has been shown that NPY protects cells against neurotoxic damage from β-amyloid peptides (Aβ) in Alzheimer's disease (AD). 28737807

2017

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Overall, increased delivery of NPY to the CNS for AD might be an effective therapy especially if combined with an anti-Aβ therapeutic. 26620558

2016

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Numbers of neuropeptide Y (NPY) and parvalbumin (PV) immunoreactive (IR) cells were decreased in the hippocampus of 1 month-old TgCRND8 mouse AD model in a sub-regionally specific manner. 28154533

2016

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Finally, we recapitulate our recent in-vitro evidence for the involvement of neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in the neuroprotective effect elicited by NPY in AD neuron-like models (neuroblastoma cells or primary cultures exposed to toxic concentrations of Aβ's pathogenic fragment 25-35), and propose a putative mechanism based on NPY-induced inhibition of voltage-dependent Ca(2+) influx in pre- and post-synaptic neurons. 25026432

2014

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. 19176820

2009

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 GeneticVariation BEFREE Our data support the observation, that NPY polymorphisms might influence cholesterol metabolism, but might not act as major risk factor in AD. 15959845

2006

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 GeneticVariation BEFREE Since APOE varepsilon4 allele is also a major risk factor for the development of Alzheimer's disease (AD) and the genetic polymorphism of NPY has not previously been studied in dementing disorders, we have examined whether a novel polymorphism in a signal peptide of NPY gene is associated with AD alone or in combination with APOE varepsilon4. 10841982

2000