Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 Biomarker HPO

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 SusceptibilityMutation ORPHANET

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 CausalMutation CGI

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation UNIPROT

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation BEFREE Detection of novel germ-line p53 mutations in diverse-cancer-prone families identified by selecting patients with childhood adrenocortical carcinoma. 1569604

1992

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation BEFREE These data suggest that mutational inactivation of the p53 gene occurs in a minority (20%) of sporadic adrenocortical carcinomas and that these mutations constitute a late event in the multi-step process of malignant transformation. 8509216

1993

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation BEFREE High frequency of germline p53 mutations in childhood adrenocortical cancer. 7966399

1994

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 Biomarker BEFREE We conclude that p53 plays a role in the tumorigenesis of adrenocortical carcinomas but is of less importance to benign adenomas. 8126158

1994

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation BEFREE Germline mutations in p53 were a feature of families which included children with rhabdomyosarcoma and/or adrenal cortical carcinoma. 8118819

1994

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 AlteredExpression BEFREE The associated adrenal cortical carcinoma of the same case also showed overexpression of p53 protein, but no mutation of the p53 gene. 7674087

1995

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation BEFREE Allelic losses at the p53 and RB loci were detected in all tumor samples, suggesting that the p53 and RB genes are involved in the tumorigenesis of adrenocortical carcinoma. 8640732

1996

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation BEFREE We previously reported mutations in the "hot spots" between exons 5-8 of the p53 gene in adrenocortical carcinomas but not in adenomas. 8855814

1996

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation BEFREE There were marked organ-specific differences in the mean age at which carriers of p53 germline mutations present with neoplastic disease: 5 years for adrenocortical carcinomas, 16 years for sarcomas, 25 years for brain tumors, 37 years for breast cancer, and almost 50 years for lung cancer. 9006316

1997

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation BEFREE Simultaneous adrenocortical carcinoma and ganglioneuroblastoma in a child with Turner syndrome and germline p53 mutation. 9598730

1998

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation BEFREE Germline p53 mutations carry an increased risk of development of breast cancer, soft tissue and osteosarcomas, brain tumors, leukemia and adrenocortical carcinomas. 9825943

1998

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 AlteredExpression BEFREE One adrenocortical carcinoma tissue showed very high p53 protein content (3000 pg/mg cytosolic protein). 9972675

1999

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 Biomarker CTD_human A patient with adrenocortical carcinoma: characterization of its biological activity and drug resistance profile. 9815696

1999

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation BEFREE Oncogenes and tumour-suppressor genes involved in adrenal carcinomas include mutations in the p53 tumour-suppressor gene and rearrangements of the chromosomal locus 11p15.5 associated with IGF II hyperexpression. 11281372

2001

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation BEFREE Mutations in the TP53 gene are frequent in adrenocortical carcinomas and might be used as a marker of malignancy. 11454518

2001

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation BEFREE An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma. 11481490

2001

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 Biomarker LHGDN pH-sensitive molecular defect of p53 (R337H) suggests that pH-dependent p53 dysfunction is the molecular basis for cases of adrenocortical carcinoma in Brazilian children 11753428

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation BEFREE Germline mutations of the p53 coding region are present in approximately 50-70% of patients with Li-Fraumeni Syndrome (LFS), a rare hereditary disorder of familial and intraindividual clustering of different malignancies such as sarcoma (index tumor), breast cancer, brain tumors, leukemias, and adrenocortical carcinomas, the latter usually in young children. 12200603

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation BEFREE The tetramerization domain for wild-type p53 (p53tet-wt) and a p53 mutant, R337H (p53tet-R337H), associated with adrenocortical carcinoma (ACC) in children, can be converted from the soluble native state to amyloid-like fibrils under certain conditions. 12634062

2003

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation BEFREE Rhabdomyosarcoma, osteosarcoma, and adrenocortical carcinoma in a child with a germline p53 mutation. 15390294

2004

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.800 GeneticVariation BEFREE Recently, a characteristic TP53 mutation at codon 337 (R337H) has been identified in the germline of children with adrenocortical carcinoma in Southern Brazil. 15878142

2005