|
HLA-DRB1
|
Graves Disease
|
0.100 |
Biomarker |
BEFREE |
The frequencies of DRB1*03 was significantly increased in GD compared to controls (OR = 2.07; 95% CI = 1.24-3.44), whereas DRB1*13 (OR = 0.33; 95% CI = 0.18-0.61) and DRB1*07 (OR = 0.31; 95% CI = 0.13-0.70) were significantly increased in controls compared to patients.
|
17284224 |
2007 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
Biomarker |
BEFREE |
A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect.
|
17597093 |
2007 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
Biomarker |
BEFREE |
In conclusion, our results clearly identify that HLA-DRB1*09:01 confers susceptibility to GD and DRB1*12:02 exerts protection against GD development in Taiwanese children.
|
22731780 |
2012 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
GeneticVariation |
BEFREE |
Allele frequencies of 40 established and suggested GD/AITD genetic risk variants (39 SNPs and HLA-DRB1*03) were compared between POGD (N = 179), AOGD (N = 1088) and healthy controls.
|
30358895 |
2019 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
GeneticVariation |
BEFREE |
The T1D protective allele DRB1*12:02 was shown to be protective against Graves' disease in our previous report.
|
29383806 |
2018 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
Biomarker |
BEFREE |
To investigate this possibility, 133 (26 males) unrelated caucasian patients with GD and 104 (43 males) control subjects were typed for HLA-DRB1, -DQA1, and -DQB1, using sequence-specific oligonucleotide probes to analyze polymerase chain reaction-amplified DNA.
|
8027232 |
1994 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
GeneticVariation |
BEFREE |
The members of maternal pedigree including both affected and unaffected Graves' disease had haplotypes of DRB1*150101 and DQB1*0602, except for the cousin who had DRB1*140301 and DQB1*030101.
|
17785916 |
2007 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated the associations of genetic variants at the HLA-B and HLA-DRB1 loci and 32 candidate single nucleotide polymorphisms (SNPs) with agranulocytosis in 29 patients with ATD-induced agranulocytosis and in 140 patients with Graves' disease (GD) as controls.
|
28931918 |
2017 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
GeneticVariation |
BEFREE |
Although the Brazilian population comprises individuals of several ethnic backgrounds, these results corroborate the participation of the HLA-DRB1*0301 and HLA-DQA1*0501 alleles as susceptibility markers for GD, and emphasize the participation of the HLA-DQB1*0602 allele as conferring protection against the development of the disease.
|
11272094 |
2001 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
GeneticVariation |
BEFREE |
We found that DRB1*0803 (P < 0.02), DRB1*1403 (P < 0.03), DQA1*0103 (P < 0.02) alleles and DRB1*0803-DQA1*0103-DQB1*0601 (P < 0.01), DRB1*1403-DQA1*0501-DQB1*0301 (P < 0.02) haplotypes were significantly increased in GD patients.
|
7704083 |
1994 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
Biomarker |
BEFREE |
To extend previous results, the amino acid sequence of the exon 2-encoded peptide-binding domain of DRB1 was predicted for each subject, and, by use of logistic regression, each position was analyzed for association with GD.
|
15558498 |
2005 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
Biomarker |
BEFREE |
Although HLA class II alleles associated with GD in Koreans were different from those in Caucasians, some associations are shared, such as association of DRB1*0301 in male patients and protective effect of DRB1*0701 to GD susceptibility.
|
15993720 |
2005 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
GeneticVariation |
BEFREE |
These results indicate that TNF G-308A is associated with susceptibility to GD (however, this association is not independent of HLA-DRB1*03) and that TNF G-238A is associated with the development of ophthalmopathy, suggesting that G-238A or a gene in linkage disequilibrium may be disease modifying in GD.
|
15219383 |
2004 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, there is increasing evidence for a genetic interaction between thyroglobulin variants and DRb1-Arg74 in conferring risk for GD.
|
18178059 |
2008 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
GeneticVariation |
BEFREE |
Interaction of HLA-DRB1 alleles with CTLA-4 in the predisposition to Graves' disease: the impact of DRB1*07.
|
16756466 |
2006 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
Biomarker |
BEFREE |
Although the phenotype frequency of DRB1*0901 was not different among Graves' disease patients with or without ophthalmopathy and control subjects, the phenotype frequency of DRB1*0901(-)/-1031C(+) was significantly increased in Graves' disease patients with ophthalmopathy compared to those with no or mild ophthalmopathy (OR = 4.91, P = 0.0005) or control subjects (OR = 4.59, P < 0.0001).
|
10848881 |
2000 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
GeneticVariation |
BEFREE |
Graves' disease (GD) is associated with the histocompatibility leucocyte antigen (HLA) haplotype A*01-B*0801-DRB1*0301-DQA1*0501-DQB1*0201 (or B8/DR3) whereas autoimmune hypothyroidism (AIH) has been weakly associated with HLA DRB1*03, *04 and *11/*12 alleles (or DR3, DR4 and DR5).
|
11678832 |
2001 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
GeneticVariation |
BEFREE |
These results show that association of the LMP 2 locus with Graves' disease is due to linkage disequilibrium with the associated HLA haplotype DRB1*0304-DQB1*02-DQA1*0501.
|
10468973 |
1999 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
Biomarker |
BEFREE |
However, the combinations such as 'DRB1*10+AA' (PL: p=1.8×10<sup>-6</sup>; HT: p=0.003) and 'DRB1*15+AA' (PL: p=0.006; GD: p=0.011) were decreased in patients showing a protective association.
|
29174716 |
2018 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
GeneticVariation |
BEFREE |
We applied HLA imputation to genome-wide association study (GWAS) data for Graves' disease in Japanese (n = 9,003) and found that amino acid polymorphisms of multiple class I and class II HLA genes independently contribute to disease risk (HLA-DPB1, HLA-A, HLA-B and HLA-DRB1; P < 2.3 × 10(-6)), with the strongest impact at HLA-DPB1 (P = 1.6 × 10(-42)).
|
26029868 |
2015 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
Biomarker |
BEFREE |
When the haplotypes of DRB1*03-DRB3 of all subtypes were removed for analysis (all DRB1*03 positive also had DRB3*0101), the frequency of DRB3*0202 remained significantly higher in the patients with later onset of Graves' disease than in controls (P = 0.0043; chi2 = 8.13), but DRB3 was no longer positively associated with the early-onset group.
|
10487684 |
1999 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
GeneticVariation |
BEFREE |
the association of HLA-DRB1 and DQB1 genotype with susceptibility to childhood onset GD differs from that in adult onset GD, whereas the association between CTLA-4 gene polymorphism and childhood onset GD is similar to that in adult onset GD in Japanese individuals, but the association is weak.
|
15640608 |
2005 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
Biomarker |
BEFREE |
Also, no statistically significant differences were observed after stratifying patients for DRB1*03- or GD-associated variants in CTLA4 or TSHR genes.
|
24289805 |
2014 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
GeneticVariation |
BEFREE |
The protective alleles for Graves' disease were DRB1 *0901 (0.9% vs. 20.2%; RR = 0.04; Pc < 0.001), DRB1*1001 (0.0% vs. 11%; RR = 0.0%; Pc < 0.01) and DRB4 *0101 (0.0% vs. 12.5%; RR = 0.0; Pc < 0.05).
|
11895223 |
2001 |
|
HLA-DRB1
|
Graves Disease
|
0.100 |
GeneticVariation |
BEFREE |
The development of CD in patients with GD was strongly associated with HLA-DQ2 haplotype (as predicted from linkage disequilibria, 14.6% vs. 1.5%, P = .009; odds ratio [OR] = 11.3; 95% confidence interval [CI] 1.3-252.7): 6 patients with CD carried HLA-DRB1(*)03, 1 carried an HLA-DRB1(*)04 allele, and 1 had an HLA-DRB1(*)07/(*)11 genotype.
|
26121457 |
2015 |