Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Furthermore, combinations of polymorphisms with IFN-γ -874 were associated with LTBI, whereas combinations with IL10 - 1082 were more likely associated with PTB. 25887222

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE On the contrary, minor allele "A" of rs2069705 in <i>IFNG</i> significantly increased the risk of PTB under genotype, dominant and additive model (<i>P</i><0.05). 29228700

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation LHGDN The association of interferon-gamma (IFN-gamma) and IFN-gamma receptor 1 (IFN-gammaR1) gene polymorphisms with pulmonary TB is controversial. 17986123

2007

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE In order to further explore the results in a Chinese Han population, this study was designed to investigate potential associations between the polymorphisms in <i>IFNG</i> and <i>IFNGR1</i> and susceptibility to latent tuberculosis infection (LTBI) and/or PTB in a Chinese Han population. 31687049

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Interferon-gamma and interleukin-10 gene polymorphisms in pulmonary tuberculosis. 12531774

2003

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE The +874 AA genotype (low IFN-γ producer) was significantly associated with increased risk of developing of active pulmonary TB (odds ratio [OR] = 2.18; 95% confidence intervals [CI], 1.33-3.57; P corrected for the number of genotypes [Pc] = 0.003). 21332391

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE The IFN-gamma and IFN-gammaR1 gene polymorphisms do not appear to be responsible for host susceptibility to pulmonary TB in the Korean population. 17986123

2007

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE We determined by pyrosequencing the distribution of the interferon-gamma+874T-A polymorphism in a Turkish population of 319 patients with pulmonary tuberculosis, 42 children with severe forms of tuberculosis and 115 healthy donors. 17276141

2007

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE We conducted an association study in Morocco between pulmonary tuberculosis and a panel of single-nucleotide polymorphisms (SNPs) covering 14 core IL-12/IFN-γ circuit genes. 24610875

2014

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Association of IFNG gene polymorphisms with pulmonary tuberculosis but not with spinal tuberculosis in a Chinese Han population. 28867622

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Recent studies have indicated that IFN-gamma and IFN-gamma receptor 1 (IFN-gammaR1) gene polymorphisms are associated with susceptibility to pulmonary tuberculosis. 17023216

2007

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE TLR9 1174G/G and IFNG 2109 A/A) was found when comparing PTB patients with LTBI controls (p=0.004) but not with healthy controls without infection (p=0.433). 24176007

2013

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Interferon-γ (IFN-γ) plays a crucial role in resistance to mycobacterial diseases; accordingly, variants of the gene encoding this cytokine may be associated with elevated risk of contracting pulmonary tuberculosis (TB). 28562756

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE The aims of the current investigation were to determine whether functional polymorphisms in the tumor necrosis factor-alpha (TNF-alpha) gene at position -308; in the transforming growth factor-beta 1 (TGF-beta1) gene at positions -509, +869 (codon 10), and +915 (codon 25); in the interleukin-10 (IL-10) gene at position -1,082, -819 and -592; and in the intron 1 of the interferon-gamma (IFN-gamma) gene at position +874 are associated with silicosis and PTB. 18931463

2008

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Association study of polymorphisms in interferon-γ receptor genes with the risk of pulmonary tuberculosis. 25815589

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Cellular responses specific to M.tb derived bacterioferritin B (BfrB) were assessed by IFN-γ ELISPOT in three human cohorts, including healthy controls (HCs), LTBI population and pulmonary TB (PTB) patients. 29050758

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE We could not properly analyze IL17A -692 C>T (rs8193036) and IFNG +874T>A due to genotypic inconsistencies and found no evidence of association for the IL2, IL4, IL10 and TNF polymorphisms and PTB. 26840977

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Interferon gamma gene +874A/T polymorphism and intracellular interferon gamma expression in pulmonary tuberculosis. 20004112

2010

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE This study aims to explore the single and joint effect of genetic polymorphisms of interferon-gamma (IFNG) and its receptor (IFNGR1) in association with the pulmonary tuberculosis in a Chinese Han population. 24680779

2014

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Using multiple corrections, significant overall risk against PTB was observed at seven loci which included variants in IFNG at rs1861493 and rs1861494; IL1RA at rs4252019, IL4 variant rs2070874, IL12 variants rs3212220, rs2853694 and TNFB variant rs1041981. 22771610

2012

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE However, the relationship between IFN-γ and P2X7 polymorphism and TB susceptibility remains inconclusive in Iranian population. 27020872

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE We observed significantly enhanced baseline and antigen-specific levels of type 1 cytokines (gamma interferon [IFN-γ] and tumor necrosis factor alpha [TNF-α]) and a type 17 cytokine (interleukin-17 [IL-17]) and significantly diminished baseline and antigen-specific levels of proinflammatory cytokines (IL-1β and IL-18) in the whole blood of TBL individuals compared to those in the whole blood of PTB individuals. 28249842

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE Interferon gamma +874A and IL-4 -590T promoter polymorphisms were studied in 129 pulmonary tuberculosis (PTB) patients and 127 normal healthy subjects (NHS) and were associated with culture filtrate and live Mycobacterium tuberculosis induced IFNgamma and IL-4 production in peripheral blood mononuclear cells (PBMCs). 17159260

2006

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE The whole-blood interferon-gamma enzyme-linked immunosorbent assay (QuantiFERON-TB Gold [QFT-G]; Cellestis, Carnegie, Australia) has been studied mainly for diagnosing active pulmonary tuberculosis (TB) or latent TB. 19070449

2009

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE Patients diagnosed with pulmonary tuberculosis (75), volunteers with positive tuberculin skin test (70) and healthy volunteers with negative tuberculin skin test and no history of contact with tuberculosis (57) were evaluated regarding the IFNG+874 genotype and the IFN-γ levels in whole blood cultures performed using an interferon-gamma commercial kit (QuantiFERON-TB<sup>®</sup> Gold In-Tube). 29787713

2018