×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
AlteredExpression
LHGDN
Cyclooxygenase-2 expression during immortalization and breast cancer progression.
18199541 2008
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
AlteredExpression
LHGDN
Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program.
15050918 2004
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
AlteredExpression
BEFREE
Immunohistochemical analyses of human breast tumor specimens revealed a strong correlation between expression of Cox-2 and MDR1/Pgp170.
11501838 2001
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
AlteredExpression
BEFREE
High levels of the cyclooxygenase-2 (COX-2 ) protein have been associated with invasion and metastasis of breast tumors .
18386173 2009
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
AlteredExpression
BEFREE
Inducible cyclooxgenase-2 (COX-2 ) is commonly overexpressed in breast tumors and is a target for cancer therapy.
28666869 2017
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
AlteredExpression
BEFREE
The clear relationship between HER-2/neu status and COX-2 expression in human breast tumors suggests that this mechanism is likely to be operative in vivo.
11901151 2002
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
AlteredExpression
LHGDN
Similarly, we identified vascular channels in high-grade invasive ductal carcinoma of the breast over-expressing COX-2 , but not in low-grade breast tumors .
17156488 2006
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
AlteredExpression
LHGDN
Coexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer.
18190720 2008
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
Biomarker
BEFREE
COX-2 modulates mammary tumor progression in response to collagen density.27000374 2016
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
Biomarker
LHGDN
Cyclooxygenase-2 uses the protein kinase C/ interleukin-8/urokinase-type plasminogen activator pathway to increase the invasiveness of breast cancer cells.
17332916 2007
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
AlteredExpression
LHGDN
[Clinicopathologic significance of cyclooxygenase-2 mRNA expression in human breast carcinoma].
12667327 2002
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
Biomarker
LHGDN
The malignant phenotype of breast cancer cells is reduced by COX-2 silencing.
18953425 2008
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
AlteredExpression
LHGDN
COX-2 may be directly involved with mammary carcinogenesis, since expression of COX-2 is sufficient for formation of breast tumors in transgenic mice, and COX-2 selective inhibitors can suppress tumorigenesis in rodent models of breast cancer.15754118 2005
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
AlteredExpression
LHGDN
Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival.
12592372 2003
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
AlteredExpression
LHGDN
Glucocorticoid receptor changes its cellular location with breast cancer development.
17952860 2008
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
AlteredExpression
LHGDN
Association between cyclooxygenase-2 expression in atypical hyperplasia and risk of breast cancer.
18334709 2008
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
Biomarker
CTD_human
Cyclooxygenase-2 induces genomic instability, BCL2 expression, doxorubicin resistance, and altered cancer-initiating cell phenotype in MCF7 breast cancer cells.
18498876 2008
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
Biomarker
CTD_human
Cyclooxygenase-2 inhibition: effects on tumour growth, cell cycling and lymphangiogenesis in a xenograft model of breast cancer.
17285134 2007
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
Biomarker
CTD_human
Soya isoflavones suppress phorbol 12-myristate 13-acetate-induced COX-2 expression in MCF-7 cells.
16870006 2006
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
AlteredExpression
BEFREE
Agents that inhibit Cox-2 or block the biological effects of PGE2 may be useful in significantly limiting aromatase activity and proliferation of human breast tumor cells regardless of the presence of Cox-2.
16997132 2006
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
AlteredExpression
LHGDN
Possible predictive markers related to micro-metastasis in breast cancer patients.
16596190 2006
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
AlteredExpression
LHGDN
The clear relationship between HER-2/neu status and COX-2 expression in human breast tumors suggests that this mechanism is likely to be operative in vivo.
11901151 2002
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
Biomarker
LHGDN
Relationship between the expression of cyclooxygenase 2 and MDR1/P-glycoprotein in invasive breast cancers and their prognostic significance.
16168133 2005
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
Biomarker
LHGDN
NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2.
16505480 2006
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Mammary Neoplasms
0.400
Biomarker
BEFREE
Furthermore, these results showed that LV-COX-2 combination with TAM is a potential drug candidate for treatment of breast tumors expressing high levels of VEGF.
24535190 2014