×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
MicroRNA-21 (miR-21 ) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer .17968323 2008
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
miR-21 functionally interacts with the 3'UTR of chemokine CCL20 and down-regulates CCL20 expression in miR-21 transfected colorectal cancer cells.22099878 2012
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
MicroRNA-21 promotes phosphatase gene and protein kinase B/phosphatidylinositol 3-kinase expression in colorectal cancer .27350731 2016
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
MicroRNA-21 (Mir-21 ) Promotes Cell Growth and Invasion by Repressing Tumor Suppressor PTEN in Colorectal Cancer .28957811 2017
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
MicroRNA-21 (miR-21 ) expression in stromal fibroblastic cells in colorectal cancer is well-documented, whereas miR-21 expression in tumor budding cells (TBCs) is poorly described.30361805 2018
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
A case-control study including 1147 patients and 1203 controls was performed to evaluate the association of SNPs in miR-21 binding sites and colorectal cancer risk.
30569605 2019
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
CircRNA circ_0026344 as a prognostic biomarker suppresses colorectal cancer progression via microRNA-21 and microRNA-31.
29928882 2018
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Circulating Exosomal MicroRNA-21 as a Biomarker in Each Tumor Stage of Colorectal Cancer .
28376502 2017
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells.
22476768 2012
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Clinical significance of microRNA-21 as a biomarker in each Dukes' stage of colorectal cancer .
25421755 2015
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Clinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer .
21412018 2010
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Co-Detection of miR-21 and TNF-α mRNA in Budding Cancer Cells in Colorectal Cancer .
30999696 2019
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Control of MicroRNA-21 expression in colorectal cancer cells by oncogenic epidermal growth factor/Ras signaling and Ets transcription factors.
22553926 2012
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Correlation between miR-21 and miR-145 and the incidence and prognosis of colorectal cancer .
29552756 2019
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Current Status and Perspectives Regarding LNA-Anti-miR Oligonucleotides and microRNA miR-21 Inhibitors as a Potential Therapeutic Option in Treatment of Colorectal Cancer .
28401648 2017
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Detection of microRNA-21 expression as a potential screening biomarker for colorectal cancer : a meta-analysis.
25292032 2014
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Diagnostic value of circulating miR-21 for colorectal cancer : a meta-analysis.
25524942 2015
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Different miR-21 -3p isoforms and their different features in colorectal cancer .
28734015 2017
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Direct binding of microRNA-21 pre-element with Regorafenib: An alternative mechanism for anti-colorectal cancer chemotherapy?
28236743 2017
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Emerging role of microRNA-21 in colorectal cancer .
25769454 2015
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Expression levels of miR-21 (p<0.0001) and miR-221 (p<0.0001) were significantly higher, whereas expression levels of miR-150 (p=0.0054) were significantly lower in the blood samples of patients with colorectal cancer in comparison to the control group.
27798914 2016
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Expression levels of miR-21 and miR-138 in colorectal cancer and normal adjacent tissues were compared.
30675293 2019
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
For overall survival (OS), the pooled hazard ratio (HR) of higher miR-21 expression in colorectal cancer was 1.76 (95% CI: 1.34-2.32, P=0.000).
24265822 2013
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
For this purpose, miR-21 expression was quantified in a panel of colorectal cancer cell lines and clinical specimens.
24149370 2014
×
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Further studies are warranted to investigate the molecular mechanisms underlying this novel inhibitor in colorectal cancer to establish its potential value for treatment of CRC patients with high miR-21 expression.
27364574 2016