Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 GeneticVariation BEFREE Besides, CD44 variant isoform 6 (CD44v6), a protein marker for metastatic behavior in gastric cancer, and was chose as the target gene to further analyze the siRNA delivery function of PEG-g-PEI-SPION. 23179610

2013

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 GeneticVariation BEFREE CD44-SLC1A2 gene fusions in gastric cancer. 21471434

2011

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 GeneticVariation BEFREE CD44E is a frequently overexpressed variant of CD44 in gastric cancer. 26119931

2016

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 GeneticVariation BEFREE Expression of CD44 variant exons 8-10 in gastric cancer. 8636005

1995

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 GeneticVariation BEFREE Haplotypes of OPN and CD44 variants significantly influenced risk of gastric cancer. 25009318

2014

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 GeneticVariation BEFREE The generation of CD44 splice variants might be linked closely with gastric carcinoma tumorigenesis and differentiation. 10439835

1999

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 GeneticVariation BEFREE CD44 single nucleotide polymorphism and isoform switching may predict gastric cancer recurrence. 26416034

2015

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 GeneticVariation BEFREE Expression and prognostic value of the CD44 splicing variants v5 and v6 in gastric cancer. 9390037

1997

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE This study aimed to conduct a meta-analysis on 19 lncRNAs (AFAP1 antisense RNA 1 [AFAP1-AS1], CDKN2B antisense RNA 1 [ANRIL], cancer susceptibility 15 [CASC15], colon cancer associated transcript 2 [CCAT2], gastric adenocarcinoma associated, positive CD44 regulator, long intergenic noncoding RNA [GAPLINC], H19, imprinted maternally expressed transcript [H19], HOX transcript antisense RNA [HOTAIR], HOXA distal transcript antisense RNA [HOTTIP], long intergenic non-protein coding RNA 673 [LINC00673], metastasis-associated lung adenocarcinoma transcript 1 [MALAT1], maternally expressed 3 [MEG3], promoter of CDKN1A antisense DNA damage activated RNA [PANDAR], Pvt1 oncogene [PVT1], SOX2 overlapping transcript [Sox2ot], SPRY4 intronic transcript 1 [SPRY4-IT1], urothelial cancer associated 1 [UCA1], X inactive specific transcript [XIST], ZEB1 antisense RNA 1 [ZEB1-AS1] and ZNFX1 antisense RNA 1 [ZFAS1]) to systematically estimate their prognostic value in GC. 30147339

2018

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE Despite their suggested importance, the mechanistic roles of FGFR2 and gastric cancer stem cell (GCSC) marker CD44 remain unclear. 27107424

2016

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE This study was aimed to investigate the associations between single nucleotide polymorphisms of cancer stem cell marker genes, CD44 and CD133, and susceptibility and prognosis of gastric cancer. 28326835

2017

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE Therefore, CD44-SATB1-ILs represent an up-and-coming approach for eliminating gastric CICs and also a promising treatment for therapy of gastric cancer. 30349314

2018

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE Circulating tumor cells expressing cancer stem cell marker CD44 as a diagnostic biomarker in patients with gastric cancer. 28123556

2017

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE CD44 is a cell surface protein and it is widely used as a cancer stem cell marker in various cancer types including gastric cancer. 25081334

2014

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE The CD44+ gastric cancer cell model is a non-adhesion, 3-dimensional, spheroid phenotype. 23900519

2013

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE We recently identified miR-328 as one of the microRNAs targeting CD44 in gastric cancer. 25479940

2015

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE Cancer stem cell (CSC) with the mark of CD44 played an important role in GC. rMETase was wildly exploited as chemotherapeutic option for GC. 29858680

2018

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE mtDNA depletion triggers chemoresistance in cancer cell lines and is correlated with increase and decrease of CD44 and CD24 positivity respectively in HGC-27 and MKN-45 GC cell lines. 29845783

2018

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE miR-145 targeting of CD44 plays critical roles in the regulation of tumor growth and chemo-resistance in gastric cancer. 28428713

2017

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE This study determined how 3D cultures impact CD44 alternative splicing in gastric cancer (GC) cells. 27187279

2016

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE HOXA10(+)/CD44(+) expression might serve as a prognostic biomarker for GC, which needs more studies to validate. 26552644

2015

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE In the first case, in a 73-year-old female, total gastrectomy was performed for a Gastric Cancer (GC) that was proved to be, based on the immunohistochemical features (positivity for mammaglobin and estrogen receptor and negativity for E-cadherin, β-catenin, CD44 and maspin), a metastasis from an invasive lobular carcinoma of the breast, that was later confirmed. 29090670

2018

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE A CD44 specific peptide developed by phage display for targeting gastric cancer. 26140900

2015

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE USP22-NLs-CD44 may provide a novel approach to eradicate gastric cancer stem cells in the near future. 30543303

2019

Entrez Id: 960
Gene Symbol: CD44
CD44
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.100 Biomarker BEFREE In conclusion, results of the present study indicated that HDAC1 depletion inhibits the metastatic abilities of gastric cancer cells by regulating the miRNA-34a/CD44 pathway, which may be a potential target for the treatment of gastric cancer. 26035691

2015