Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Methylation of RUNX3 promoter was significantly higher in GC than normal subjects. 27664488

2016

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Our clinical and experimental data provide a novel molecular mechanism for the antitumor activity of RUNX3 and may help design effective therapy targeting RUNX3 pathway to control gastric cancer growth and metastasis. 17085650

2006

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Causal relationship between the loss of RUNX3 expression and gastric cancer. 11955451

2002

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Recent data involve RUNX3 as an important tumor suppressor in gastric cancers and pose interesting questions about how perturbed levels and interspecific competition among RUNX family members may contribute to tumorigenesis. 12086855

2002

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE MicroRNA-148a can regulate runt-related transcription factor 3 gene expression via modulation of DNA methyltransferase 1 in gastric cancer. 23549984

2013

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Spreading of methylation within RUNX3 CpG island in gastric cancer. 16367921

2006

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Runx3 was an independent prognostic factor and a potential therapeutic target for gastric cancer. 20492341

2010

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Furthermore, similar inverse trends between RUNX3 and OPN messenger RNA (mRNA) expression were demonstrated in six out of seven normal-tumor-paired gastric cancer clinical specimens. 23774402

2013

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE RUNX3 has been suggested to be a tumor suppressor of gastric cancer. 16135801

2005

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE The RUNX3 gene promoter methylation rate was much higher in tumor tissue than that in normal gastric tissue in patient with gastric cancer, which indicates a close association between gastric cancer and RUNX3 gene promoter methylation. 27721253

2016

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE These findings reveal a novel mechanism of RUNX3 for the induction of cell apoptosis in human gastric cancer. 24636883

2014

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Blocking Runx3 expression in immortalized stomach mucosal cells (GES-1) or gastric cancer cells (SGC7901) by Runx3-specific small interfering RNA conferred the cells resistance to chemotherapeutic drugs. 15756676

2005

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Runt-related transcription factor 3 (RUNX3) is a tumor suppressor of gastric cancer. 21135153

2011

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Promoter hypermethylation of p16, Runx3, DAPK and CHFR is frequent in gastric cancer. 21302620

2011

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Lack of RUNX3 regulation in human gastric cancer. 16917803

2006

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE MR ranged from 0.1% to 69.1% (mean, 18.3%) for LOX, 0.5-74.1% (mean, 15.7%) for p16, 0.2-76.5% (mean, 22.7%) for RUNX3, and 0.6-41.2% (mean, 5.8%) for TIG1 in primary gastric cancers, and from 0.1% to 25.8% (mean, 8.7%) for LOX, 1.0- 23.2% (mean, 10.3%) for p16, 0.7-25.1% (mean, 5.5%) for RUNX3, and 1.8-27.6% (mean, 11.4%) for TIG1 in corresponding non-neoplastic gastric epithelia. 20021617

2009

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE These results provide further evidence that RUNX3 can function as a tumor suppressor and suggest that practical methods to augment RUNX3 function could be useful in treating of some types of gastric cancer. 23230322

2013

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE The tumorigenicity of human gastric cancer cell lines in nude mice decreased as the level of RUNX3 expression increased, which indicates that RUNX3 is a bona fide tumor suppressor of gastric cancers. 15156190

2004

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE More than a decade ago claims arose that the RUNX3 member of the RUNX transcription factor family is a major TSG inactivated in gastric cancer, a postulate extended later to other cancers. 25641675

2015

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Aberrant promoter methylation of Runx3 and CHFR genes may be involved in the carcinogenesis and development of GC and may provide useful clues for the prediction of the malignant behaviors of GC. 20300977

2011

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Frequent loss of RUNX3 gene expression in remnant stomach cancer and adjacent mucosa with special reference to topography. 15685235

2005

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Runt-related transcription factor 3 (RUNX3) is a candidate tumor suppressor gene whose deficiency is causally related to gastric cancer. 19196394

2009

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE RUNX3 inhibits the proliferation and metastasis of gastric cancer through regulating miR-182/HOXA9. 29054094

2017

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Thus, RUNX3 suppressed gastric cancer cell invasion and vimentin expression by activating miR-30a. 24447545

2014

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE These results indicate that silencing of RUNX3 affects expression of important genes involved in aspects of metastasis including cell adhesion, proliferation, apoptosis, and promoting the peritoneal metastasis of gastric cancer. 16166423

2005