Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Causal relationship between the loss of RUNX3 expression and gastric cancer. 11955451

2002

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Recent data involve RUNX3 as an important tumor suppressor in gastric cancers and pose interesting questions about how perturbed levels and interspecific competition among RUNX family members may contribute to tumorigenesis. 12086855

2002

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Runx3 knockouts and stomach cancer. 12776174

2003

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Among samples obtained from patients with stomach cancer, methylation was observed in both the neoplastic and the corresponding non-neoplastic gastric epithelia; 43% (40/93) and 73% (68/93) for DAP-kinase, and 45% (42/93) and 8% (7/93) for RUNX3, respectively. 12824905

2003

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE However, there are limited data on the methylation status of RUNX3 in the neoplastic and non-neoplastic tissues in various types of human cancers, including gastric cancer. 14968123

2004

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE The tumorigenicity of human gastric cancer cell lines in nude mice decreased as the level of RUNX3 expression increased, which indicates that RUNX3 is a bona fide tumor suppressor of gastric cancers. 15156190

2004

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE These findings suggest that RUNX1 and CBFBeta in addition to RUNX3 play some roles in gastric cancers and that roles of RUNX gene family in gastric cancer are more widespread and complex than previously realized. 15386419

2005

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Frequent loss of RUNX3 gene expression in remnant stomach cancer and adjacent mucosa with special reference to topography. 15685235

2005

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Blocking Runx3 expression in immortalized stomach mucosal cells (GES-1) or gastric cancer cells (SGC7901) by Runx3-specific small interfering RNA conferred the cells resistance to chemotherapeutic drugs. 15756676

2005

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE RUNX3 has been suggested to be a tumor suppressor of gastric cancer. 16135801

2005

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE In addition to the deregulation of mechanisms controlling gene expression, there would also seem to be at least one other mechanism controlling nuclear translocation of RUNX3 that is impaired frequently in gastric cancer. 16140942

2005

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE These results indicate that silencing of RUNX3 affects expression of important genes involved in aspects of metastasis including cell adhesion, proliferation, apoptosis, and promoting the peritoneal metastasis of gastric cancer. 16166423

2005

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Spreading of methylation within RUNX3 CpG island in gastric cancer. 16367921

2006

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Here we discuss recent breakthroughs in our understanding of the mechanisms of RUNX3 in gastric malignancy and comment on possible future trends and perspectives. 16627973

2006

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Lack of RUNX3 regulation in human gastric cancer. 16917803

2006

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE Although RUNX1 is similar to RUNX3 in both the expression pattern in the stomach and its cell growth-inhibition activity, RUNX1 is not involved in most cases of gastric cancers. 16964375

2006

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Our clinical and experimental data provide a novel molecular mechanism for the antitumor activity of RUNX3 and may help design effective therapy targeting RUNX3 pathway to control gastric cancer growth and metastasis. 17085650

2006

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Overall, 55% of GC demonstrated methylation of the RUNX3 promoter; 82% of GC was classified as stable microsatellite instability, 5% as low-level microsatellite instability and 13% as high-level microsatellite instability (MSI-H); mtMSI was detected in 11% of GC. 17591800

2007

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Runt-related transcription factor 3 (RUNX3) has been reported to be a candidate tumor suppressor gene in gastric cancer. 18288406

2008

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE This study suggests that hypoxia silences RUNX3 by epigenetic histone regulation during the progression of gastric cancer. 18850007

2009

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Runt-related transcription factor 3 (RUNX3) is a candidate tumor suppressor gene whose deficiency is causally related to gastric cancer. 19196394

2009

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE RUNX3 expression was lost in 37 (39%) cases of gastric cancer. 19290488

2009

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE In conclusion, the RUNX3 genetic variants may modulate the risk of gastric cancer in a Chinese population. 19552756

2009

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Quantification of epigenetic changes in serum RUNX3 methylation using RTQ-MSP is useful for the detection and monitoring of gastric cancer. 19596937

2009

Entrez Id: 864
Gene Symbol: RUNX3
RUNX3
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE We found no statistically significant associations between RUNX3 rs6672420 polymorphism and risk of gastric atrophy, nor between these two RUNX3 polymorphisms and the risk of gastric cancer relative to the subjects with gastric atrophy. 19728008

2009