×
Entrez Id: 51284
Gene Symbol: TLR7
TLR7
Degenerative polyarthritis
0.010
Biomarker
BEFREE
Therefore, extracellular miR-21 released from synovial tissue mediates knee OA pain through TLR7 activation in surgical OA model rats.
31841992 2020
×
Entrez Id: 706
Gene Symbol: TSPO
TSPO
Degenerative polyarthritis
0.010
GeneticVariation
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACPA: anti-citrullinated peptide antibodies; anti-CCP: anti-cyclic citrullinated peptide antibody; cVIM: citrullinated VIM; BECN1: beclin1; DAPI: 4',6-diamidino-2-phenylindole; FBS: fetal bovine serum; HLA: human leukocyte antigen; IFNG/IFN-γ: interferon gamma; IL6: interleukin 6; IP: immunoprecipitation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFI: mean fluorescence index; MHC: major histocompatibility complex; OA: osteoarthritis ; PADI: peptidyl arginine deiminase; PepA: pepstatin A; PBS : phosphate-buffered saline; PtdIns3K: phosphatidylinositol 3-kinase; RA: rheumatoid arthritis; SFs: synovial fibroblasts; siRNA: small interfering RNA; VIM: vimentin.
31486697 2020
×
Entrez Id: 55638
Gene Symbol: SYBU
SYBU
Degenerative polyarthritis
0.010
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACPA: anti-citrullinated peptide antibodies; anti-CCP: anti-cyclic citrullinated peptide antibody; cVIM: citrullinated VIM; BECN1: beclin1; DAPI: 4',6-diamidino-2-phenylindole; FBS: fetal bovine serum; HLA: human leukocyte antigen; IFNG/IFN-γ: interferon gamma; IL6: interleukin 6; IP: immunoprecipitation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFI: mean fluorescence index; MHC: major histocompatibility complex; OA: osteoarthritis ; PADI: peptidyl arginine deiminase; PepA: pepstatin A; PBS: phosphate-buffered saline; PtdIns3K: phosphatidylinositol 3-kinase; RA: rheumatoid arthritis; SFs: synovial fibroblasts; siRNA: small interfering RNA; VIM: vimentin.
31486697 2020
×
Entrez Id: 4915
Gene Symbol: NTRK2
NTRK2
Degenerative polyarthritis
0.010
AlteredExpression
BEFREE
There was a significant positive correlation between mRNA expression of NTRK2 (TrkB) and the proinflammatory chemokine fractalkine in the OA synovia.
31479064 2020
×
Entrez Id: 5494
Gene Symbol: PPM1A
PPM1A
Degenerative polyarthritis
0.010
AlteredExpression
BEFREE
Here, we report that protein phosphatase magnesium-dependent 1A (PPM1A ) levels were increased in RA synovial fluid compared with osteoarthritis (OA ) synovial fluid and positively correlated with TNF levels.
31791585 2020
×
Entrez Id: 4745
Gene Symbol: NELL1
NELL1
Degenerative polyarthritis
0.010
Biomarker
BEFREE
Here, for the first time, we demonstrated the emerging role of neural EGFL like 1 (NELL-1 ) in arthritis pathogenesis by showing that Nell-1 -haploinsufficient (Nell-1<sup>+/6R</sup>) mice had accelerated and aggravated osteoarthritis (OA ) progression with elevated inflammatory markers in both spontaneous primary OA and chemical-induced secondary OA models.
31634652 2020
MELTF-AS1
Degenerative polyarthritis
0.010
AlteredExpression
BEFREE
MFI2-AS1 expression was increased in osteoarthritis tissues and LPS-treated C28/I2 cells.31678554 2020
×
Entrez Id: 55177
Gene Symbol: RMDN3
RMDN3
Degenerative polyarthritis
0.010
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACPA: anti-citrullinated peptide antibodies; anti-CCP: anti-cyclic citrullinated peptide antibody; cVIM: citrullinated VIM; BECN1: beclin1; DAPI: 4',6-diamidino-2-phenylindole; FBS: fetal bovine serum; HLA: human leukocyte antigen; IFNG/IFN-γ: interferon gamma; IL6: interleukin 6; IP: immunoprecipitation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFI: mean fluorescence index; MHC: major histocompatibility complex; OA: osteoarthritis ; PADI: peptidyl arginine deiminase; PepA: pepstatin A; PBS: phosphate-buffered saline; PtdIns3K: phosphatidylinositol 3-kinase; RA: rheumatoid arthritis; SFs: synovial fibroblasts; siRNA: small interfering RNA; VIM: vimentin.
31486697 2020
×
Entrez Id: 90
Gene Symbol: ACVR1
ACVR1
Degenerative polyarthritis
0.010
Biomarker
BEFREE
These phenotypes appear to be uncoupled from heterotopic bone formation, indicating a potential role for ACVR1 in the development and progression of degenerative joint disease .
31655222 2020
×
Entrez Id: 8013
Gene Symbol: NR4A3
NR4A3
Degenerative polyarthritis
0.010
Biomarker
BEFREE
We suggest that NR4A3 plays a pro-inflammatory role in the development of OA , and we also speculate that NR4A3 mainly regulates cartilage matrix-degrading gene expression under inflammatory conditions via the NF-κB pathway.
31701670 2020
×
Entrez Id: 151393
Gene Symbol: RMDN2
RMDN2
Degenerative polyarthritis
0.010
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACPA: anti-citrullinated peptide antibodies; anti-CCP: anti-cyclic citrullinated peptide antibody; cVIM: citrullinated VIM; BECN1: beclin1; DAPI: 4',6-diamidino-2-phenylindole; FBS: fetal bovine serum; HLA: human leukocyte antigen; IFNG/IFN-γ: interferon gamma; IL6: interleukin 6; IP: immunoprecipitation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFI: mean fluorescence index; MHC: major histocompatibility complex; OA: osteoarthritis ; PADI: peptidyl arginine deiminase; PepA: pepstatin A; PBS: phosphate-buffered saline; PtdIns3K: phosphatidylinositol 3-kinase; RA: rheumatoid arthritis; SFs: synovial fibroblasts; siRNA: small interfering RNA; VIM: vimentin.
31486697 2020
×
Entrez Id: 51378
Gene Symbol: ANGPT4
ANGPT4
Degenerative polyarthritis
0.010
Biomarker
BEFREE
These results demonstrate that dual functional nanoparticles containing SOX duo and ANGPT4 shRNA enhance chondrogenesis of ADSCs and suppress inflammation in OA .
30957437 2020
×
Entrez Id: 442913
Gene Symbol: MIR376C
MIR376C
Degenerative polyarthritis
0.010
Biomarker
BEFREE
XIST/miR-376c -5p/OPN axis modulates the influence of proinflammatory M1 macrophages on osteoarthritis chondrocyte apoptosis.
31215024 2020
×
Entrez Id: 51115
Gene Symbol: RMDN1
RMDN1
Degenerative polyarthritis
0.010
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACPA: anti-citrullinated peptide antibodies; anti-CCP: anti-cyclic citrullinated peptide antibody; cVIM: citrullinated VIM; BECN1: beclin1; DAPI: 4',6-diamidino-2-phenylindole; FBS: fetal bovine serum; HLA: human leukocyte antigen; IFNG/IFN-γ: interferon gamma; IL6: interleukin 6; IP: immunoprecipitation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFI: mean fluorescence index; MHC: major histocompatibility complex; OA: osteoarthritis ; PADI: peptidyl arginine deiminase; PepA: pepstatin A; PBS: phosphate-buffered saline; PtdIns3K: phosphatidylinositol 3-kinase; RA: rheumatoid arthritis; SFs: synovial fibroblasts; siRNA: small interfering RNA; VIM: vimentin.
31486697 2020
×
Entrez Id: 6446
Gene Symbol: SGK1
SGK1
Degenerative polyarthritis
0.010
Biomarker
BEFREE
Taken together, we identified a critical role of SGK1 in the IL-1β-induced chondrocyte anabolic and catabolic imbalance, which may represent a potential novel therapeutic target for OA .
31330080 2020
×
Entrez Id: 50488
Gene Symbol: MINK1
MINK1
Degenerative polyarthritis
0.010
AlteredExpression
BEFREE
Dual roles of misshapen/NIK-related kinase (MINK1 ) in osteoarthritis subtypes through the activation of TGFβ signaling.
31647983 2020
×
Entrez Id: 7702
Gene Symbol: ZNF143
ZNF143
Degenerative polyarthritis
0.010
Biomarker
BEFREE
The application of SBF SEM to hard tissues will facilitate qualitative and quantitative 3D studies of tissue microstructure and ultrastructure in bone development, ageing and pathologies such as osteoporosis and osteoarthritis .
31669251 2020
×
Entrez Id: 1131
Gene Symbol: CHRM3
CHRM3
Degenerative polyarthritis
0.010
GeneticVariation
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ACPA: anti-citrullinated peptide antibodies; anti-CCP: anti-cyclic citrullinated peptide antibody; cVIM: citrullinated VIM; BECN1: beclin1; DAPI: 4',6-diamidino-2-phenylindole; FBS: fetal bovine serum; HLA: human leukocyte antigen; IFNG/IFN-γ: interferon gamma; IL6: interleukin 6; IP: immunoprecipitation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MFI: mean fluorescence index; MHC: major histocompatibility complex; OA: osteoarthritis ; PADI: peptidyl arginine deiminase; PepA: pepstatin A; PBS : phosphate-buffered saline; PtdIns3K: phosphatidylinositol 3-kinase; RA: rheumatoid arthritis; SFs: synovial fibroblasts; siRNA: small interfering RNA; VIM: vimentin.
31486697 2020
×
Entrez Id: 494326
Gene Symbol: MIR377
MIR377
Degenerative polyarthritis
0.010
Biomarker
BEFREE
In our study, we demonstrated that miR-377 -3p is underexpressed in OA -affected cartilage and IL-1β-treated chondrocytes.
31831175 2020
×
Entrez Id: 939
Gene Symbol: CD27
CD27
Degenerative polyarthritis
0.010
Biomarker
BEFREE
CD3-CD19+IgD-IgM-CD27 +CD38+ B cells were decreased in OA (p ≤ 0.001).
31624962 2020
×
Entrez Id: 6237
Gene Symbol: RRAS
RRAS
Degenerative polyarthritis
0.010
Biomarker
BEFREE
The present results suggest that RAS-related components in RA and OA , including renin, ACE, angiotensin type 1 and type 2 receptors, are associated with increased expression of VEGF and play an important role in angiogenesis.
31785770 2020
×
Entrez Id: 2869
Gene Symbol: GRK5
GRK5
Degenerative polyarthritis
0.010
AlteredExpression
BEFREE
Conversely, GRK5 overexpression significantly increased expressions of OA -related catabolic mediators and NF-κB transcriptional activation.
31696655 2020
×
Entrez Id: 406901
Gene Symbol: MIR107
MIR107
Degenerative polyarthritis
0.010
AlteredExpression
BEFREE
Overexpression of miR-107 inhibited apoptosis and promoted autophagy in OA chondrocytes.
30909133 2019
×
Entrez Id: 8935
Gene Symbol: SKAP2
SKAP2
Degenerative polyarthritis
0.010
Biomarker
BEFREE
Moreover, among the 14 dysregulated genes with potential miRNA regulations identified, src kinase associated phosphoprotein 2 (<i>SKAP2</i>), adaptor related protein complex 1 sigma 2 subunit (<i>AP1S2</i>), PHD finger protein 21A (<i>PHF21A</i>), lipoma preferred partner (<i>LPP</i>), and transcription factor AP-2 alpha (<i>TFAP2A</i>) showed similar expression patterns in OA FLS and OA synovial tissue datasets in Gene Expression Omnibus database.
31523167 2019
×
Entrez Id: 6351
Gene Symbol: CCL4
CCL4
Degenerative polyarthritis
0.010
AlteredExpression
BEFREE
OA mice models were established, after which the CCL4 and collagen levels as well as cell apoptosis were determined in cartilage tissue of OA mice.
30940879 2019