Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2965
Gene Symbol: GTF2H1
GTF2H1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE However, p62 increased progressively with increasing disc degeneration grade. 31802633

2020

Entrez Id: 8878
Gene Symbol: SQSTM1
SQSTM1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE However, p62 increased progressively with increasing disc degeneration grade. 31802633

2020

Entrez Id: 10725
Gene Symbol: NFAT5
NFAT5
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE TonEBP-deficiency accelerates intervertebral disc degeneration underscored by matrix remodeling, cytoskeletal rearrangements, and changes in proinflammatory gene expression. 31707045

2020

Entrez Id: 406954
Gene Symbol: MIR181A2
MIR181A2
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE MicroRNA-181a exerts anti-inflammatory effects via inhibition of the ERK pathway in mice with intervertebral disc degeneration. 31508816

2020

Entrez Id: 10657
Gene Symbol: KHDRBS1
KHDRBS1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE However, p62 increased progressively with increasing disc degeneration grade. 31802633

2020

Entrez Id: 51164
Gene Symbol: DCTN4
DCTN4
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE However, p62 increased progressively with increasing disc degeneration grade. 31802633

2020

Entrez Id: 23636
Gene Symbol: NUP62
NUP62
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE However, p62 increased progressively with increasing disc degeneration grade. 31802633

2020

Entrez Id: 3920
Gene Symbol: LAMP2
LAMP2
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE LAMP2 rose with increasing disc degeneration grade through grade V. In the quantitative analysis of colocalization, grade III is significantly higher than grade II and V (P < 0.05). 31802633

2020

Entrez Id: 57103
Gene Symbol: TIGAR
TIGAR
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE TIGAR impedes compression-induced intervertebral disc degeneration by suppressing nucleus pulposus cell apoptosis and autophagy. 31317559

2020

Entrez Id: 23476
Gene Symbol: BRD4
BRD4
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 AlteredExpression BEFREE Our study demonstrates that inhibition of BRD4 may suppress MAPK and NF-κB signaling and activate autophagy to suppress MMP-13 expression in diabetic IVDD, and diabetic IVDD may be compromised by BRD4 inhibitors.-Wang, J., Hu, J., Chen, X., Huang, C., Lin, J., Shao, Z., Gu, M., Wu, Y., Tian, N., Gao, W., Zhou, Y., Wang, X., Zhang, X. BRD4 inhibition regulates MAPK, NF-κB signals, and autophagy to suppress MMP-13 expression in diabetic intervertebral disc degeneration. 31331201

2019

Entrez Id: 2936
Gene Symbol: GSR
GSR
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE Oxidative stress mechanisms play a crucial role in disc degeneration and GR deficiency could be an eligible risk factor for LDDD. 31028201

2019

Entrez Id: 4086
Gene Symbol: SMAD1
SMAD1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 AlteredExpression BEFREE Moreover, we found that miR-26a-5p targets Smad1 expression, and Smad1 negatively regulates Vegfa expression in disc cells, and thus, miR-26a-5p promotes disc degeneration. 31338931

2019

Entrez Id: 22933
Gene Symbol: SIRT2
SIRT2
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE However, the mechanism of SIRT2 in IVDD remains unclear. 31238070

2019

Entrez Id: 1938
Gene Symbol: EEF2
EEF2
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE MicroRNA-143-5p targeting eEF2 gene mediates intervertebral disc degeneration through the AMPK signaling pathway. 30987676

2019

Entrez Id: 2146
Gene Symbol: EZH2
EZH2
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE This work explored the role of histone methyltransferase enhancer of zeste homologue 2 (EZH2) in CEP degeneration, as well as its underlying epigenetic mechanisms, and confirmed the effect of EZH2 knockdown on delaying IVDD development. 31631036

2019

Entrez Id: 2308
Gene Symbol: FOXO1
FOXO1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE miR-486-5p Inhibits Inflammatory Response, Matrix Degradation and Apoptosis of Nucleus Pulposus Cells through Directly Targeting FOXO1 in Intervertebral Disc Degeneration. 30790508

2019

Entrez Id: 619552
Gene Symbol: MIR483
MIR483
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE Bu-Shen-Huo-Xue-Fang modulates nucleus pulposus cell proliferation and extracellular matrix remodeling in intervertebral disk degeneration through miR-483 regulation of Wnt pathway. 29393545

2019

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 AlteredExpression BEFREE The gene expression of insulin-like growth factor binding protein 3 (IGFBP3) is increased in patients with disc degeneration, however, its mechanism is still unknown. 30370550

2019

Entrez Id: 4804
Gene Symbol: NGFR
NGFR
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 AlteredExpression BEFREE Finally, neuronal nuclear hypertrophy and elevated expression of p75NTR provide evidence of active adaptation of innervating sensory neurons in chronic intervertebral disc degeneration. 30842475

2019

Entrez Id: 7942
Gene Symbol: TFEB
TFEB
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 AlteredExpression BEFREE Furthermore, TFEB overexpression ameliorates the puncture-induced IVDD development in rats. 30414849

2019

Entrez Id: 2475
Gene Symbol: MTOR
MTOR
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE Our objective was to identify the optimal mTOR inhibitor for treating human degenerative disc disease. 30716534

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 AlteredExpression BEFREE Herein we report that PPAR-γ was down-regulated both in the nucleus pulposus tissue of intervertebral disc degeneration patient and in the cultured nucleus pulposus cells stimulated with IL-17. 30981079

2019

Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE Glycyrrhizin suppresses inflammation and cell apoptosis by inhibition of HMGB1 via p38/p-JUK signaling pathway in attenuating intervertebral disc degeneration. 31497226

2019

Entrez Id: 574501
Gene Symbol: MIR499A
MIR499A
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 AlteredExpression BEFREE Nonetheless, the expression level and biological function of miR-499a-5p in IVDD are still unclear. 30856535

2019

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.010 Biomarker BEFREE IL-8 was elevated in CSF of chronic LBP patients with DD compared to pain-free subjects with or without DD. 31047862

2019