Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 100329167
Gene Symbol: AAA1
AAA1
Diabetes Mellitus, Non-Insulin-Dependent
0.020 AlteredExpression BEFREE Ac-terAA1 and AAA1 levels and were similar between T2D and control subjects. 30744100

2019

Entrez Id: 100329167
Gene Symbol: AAA1
AAA1
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE In weighted Cox regression models, we found that baseline lysine (HR<sub>+1 SD increase</sub> = 1.26; 95% CI 1.06-1.51) and 2-AAA (HR<sub>+1 SD increase</sub> = 1.28; 95% CI 1.05-1.55) were both associated with a higher risk of T2D, but not with CVD. 31722714

2019

Entrez Id: 8086
Gene Symbol: AAAS
AAAS
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE In weighted Cox regression models, we found that baseline lysine (HR<sub>+1 SD increase</sub> = 1.26; 95% CI 1.06-1.51) and 2-AAA (HR<sub>+1 SD increase</sub> = 1.28; 95% CI 1.05-1.55) were both associated with a higher risk of T2D, but not with CVD. 31722714

2019

Entrez Id: 17
Gene Symbol: AAVS1
AAVS1
Diabetes Mellitus, Non-Insulin-Dependent
0.010 Biomarker BEFREE The aim of present study was to characterize the site-specific profile and metabolic effects of Ex-4 levels expressed from salivary glands (SG) in vivo, following adeno-associated virus-mediated (AAV) gene therapy in two different animal models of obesity prone to impaired glucose tolerance and T2DM, specifically, Zucker fa/fa rats and high fed diet (HFD) mice. 22808093

2012

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE No association was found to the only known Native American-specific gene variant previously associated with T2D in a Mexican sample (rs9282541 in ABCA1). 22529894

2012

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE ABCA1 gene polymorphism might not be a genetic risk factor for T2DM subjects among Bangladeshis. 30529097

2019

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE R219K polymorphism of ABCA1 gene can be considered as a genetic risk factor for T2DM subjects among Malaysians. 26451383

2015

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker BEFREE Leukocyte ABCA1 protein was lower in T2DM (p = 0.03) and positively associated with plasma HDL cholesterol (HDL-C) (rho = 0.34, p = 0.02). 21829447

2011

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The R230C ABCA1 variant is associated with type 2 diabetes, particularly of early onset, in the Mexican-Mestizo population. 18003760

2008

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker BEFREE While the ELISA analysis showed that; both TAF1C and FN were significantly increased in T2DM (P0.015 and P0.001, respectively), while CERP was not (P0.088). 31039436

2019

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE Levels of PPARalpha, PPARgamma, LXRalpha, SCD and ABCA1 mRNAs were similar in macrophages from subjects with T2DM and controls. 16908084

2007

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE We studied the association of common single nucleotide polymorphisms (SNPs) in the ABCA1 gene with HDL-C levels and coronary risk in a cohort of subjects with T2D. 19059534

2009

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Effects of ABCA1 variants on rosiglitazone monotherapy in newly diagnosed type 2 diabetes patients. 18215356

2008

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The ABCA1 SNP rs4149263 may be associated with the change in atherogenic lipid profile in Type 2 diabetes treated with rosiglitazone. 19538231

2009

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker BEFREE ABCA1 protein correlated positively with HDL-cholesterol (r = 0.655, p = 0.021) in AMI patients with T2DM and negatively with age (r = - 0.525, p = 0.031) in AMI patients without T2DM and it was more strongly associated in latter group with smoking and alcohol habit. 24796288

2015

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker BEFREE These studies highlight a novel role for hepatic ABCA1 in the metabolism of all three major classes of plasma lipoproteins and provide a metabolic link between elevated TG and reduced HDL levels that are a common feature of Tangier disease, MS, and T2D. 22001232

2012

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Patients with type 2 diabetes who have the R230C allele of ABCA1 needed a higher dose of glyburide in order to achieve the same glucose lowering effect as that in persons with the wild type variant. 23273975

2013

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Genetic variations in ABCA1 and ABCG1 were not associated with increased risk of type 2 diabetes in the general population. 23139370

2012

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ11), rs1801282 (PPARγ), rs10811661 (CDKN2A/2B), rs13266634 (SLC30A8), rs12779790 (CDC123/CAMK1D), rs7903146 (TCF7L2), rs9282541 (ABCA1) and rs13342692 (SLC16A11) polymorphisms in the genetic background of Maya population to associate their susceptibility to develop T2D. 25839936

2015

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE To examine the association of the ATP-binding cassette transporter 1 (ABCA1) gene with type 2 diabetes (DM), we studied genetic polymorphisms of the ABCA1 gene including its linkage disequilibrium (LD) and haplotype analyses using a Japanese population. 15721294

2005

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Here, we analyzed the association between a variant form of ABCA1 gene called <i>ABCA1</i> rs2230806 and the prevalence of T2DM in a large sample size by pooling all of the case-control studies published. 29621814

2018

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker BEFREE In this report, a relationship between ApoA-I, DM and ABCA1 has been emphasized. 16009332

2005

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The associations between SNPs of TCF7L2 (rs7903146 and rs12255372), SLC16A11 (rs13342232), and ABCA1 (rs9282541) with T2D were analyzed. 28101933

2017

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Investigation of ABCA1 C69T polymorphism in patients with type 2 diabetes mellitus. 22384526

2012

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE In contrast, ABCA1 expression in macrophages was similar in both control subjects and patients with type 2 diabetes mellitus. 18490524

2008