Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation CLINVAR

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation BEFREE Alzheimer's Disease Neuroimaging Initiative cohort (ADNI; n=237) data, combining both multiplexed proteomics CSF and genotype data, were used to assess the association between CSF analytes and risk SNPs in four genes (SNPs): GRN (rs5848), TMEM106B (rs1990622), ABCC9 (rs704180), and KCNMB2 (rs9637454). 28189700

2017

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker BEFREE Alzheimer disease is due to increased amyloid-β coupled with low progranulin. 30336989

2018

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation BEFREE PGRN mutations were also identified in other neurodegenerative brain diseases such as amyotrophic lateral sclerosis and Alzheimer disease, though their biologic contribution to these diseases remains elusive. 18838661

2008

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker BEFREE Progranulin plasma levels as potential biomarker for the identification of GRN deletion carriers. A case with atypical onset as clinical amnestic Mild Cognitive Impairment converted to Alzheimer's disease. 19683260

2009

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation BEFREE GRN mutation cases are quantitatively different from sporadic cases, while cases with associated HS and AD have increased densities of dystrophic neurites and abnormally enlarged neurones respectively. 21696412

2012

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation BEFREE Progranulin plasma levels were analyzed in a variety of FTLD phenotypes (n = 71), dementia of the Alzheimer type (DAT) (n = 22) and probable Lewy body dementia (n = 8), both latter groups presented with asymmetric perisylvian atrophy. 23724906

2013

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation BEFREE Progranulin (PGRN) mutations are associated with different clinical phenotypes, including frontotemporal lobar degeneration (FTLD), corticobasal syndrome (CBS) and Alzheimer's disease (AD). 24022032

2014

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker BEFREE Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models. 25261995

2014

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker BEFREE Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer's disease model mice. 28845019

2018

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 AlteredExpression BEFREE Progranulin expression was 13% higher in AD and MCI patients compared with controls in the UCSF-MAC cohort (<i>F</i><sub>2,505</sub> = 10.41, <i>P</i> = 3.72*10<sup>-5</sup>). 29761124

2018

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker BEFREE Progranulin has received attention due to its role in neurodegeneration, where mutation of a single copy of GRN, the gene encoding progranulin, results in frontotemporal dementia, whereas viral delivery of progranulin to the brains of mice exhibiting Parkinson's or Alzheimer's disease phenotypes inhibits the progression of the neurodegenerative phenotypes. 29956265

2018

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation BEFREE rs5848 variant of progranulin gene is a risk of Alzheimer's disease in the Taiwanese population. 21212639

2011

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation LHGDN A mutation scanning of exons and flanking regions of PGRN was carried out in 120 patients with sporadic frontotemporal lobar degeneration and 145 with sporadic AD. 18752597

2008

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation BEFREE A mutation scanning of exons and flanking regions of PGRN was carried out in 120 patients with sporadic frontotemporal lobar degeneration and 145 with sporadic AD. 18752597

2008

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation BEFREE Although CSF sTREM2 levels are not raised in FTD overall or in a particular clinical subtype of FTD, levels are raised in familial FTD associated with GRN mutations and in FTD syndromes due to AD pathology. 30111356

2018

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker BEFREE Because cellular and animal data indicate that increasing PGRN can reverse phenotypes of both FTD and AD, modulating PGRN level has been proposed as a therapeutic strategy for both diseases. 28069809

2017

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation BEFREE Because the penetrance rate of the clinical phenotype of carriers of GRN mutations is age-dependent, further research is required to investigate the role of co-occurring age-related pathologies such as AD, PART, and cerebral small vessel disease. 29370838

2018

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker BEFREE By understanding PGRN in a wider context, we may be better able to depict its role in AD and then provide a therapeutic strategy for AD. 26215834

2016

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation BEFREE C9orf72 repeat expansions were present in 0.4 % of AD and in 9.9 % of FTD patients, whereas MAPT and GRN mutations both were present in 0.4 % in AD patients, and in 1.4 % resp.2.7 % in FTD patients. 25108559

2014

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker BEFREE CSF levels of routine AD biomarkers (phosphorylated tau (p-tau<sub>181</sub>), total tau (t-tau), and amyloid-beta (Aβ)<sub>1-42</sub>) and neurofilament proteins, as well as progranulin levels in both CSF and serum were quantified in definite FTLD (n = 46), clinical AD (n = 45), and cognitively healthy controls (n = 20). 29559004

2018

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker BEFREE Defective lysosomal function defines many neurodegenerative diseases, such as neuronal ceroid lipofuscinoses (NCL) and Niemann-Pick type C (NPC), and is implicated in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD-TDP) with progranulin (PGRN) deficiency. 28903038

2017

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 AlteredExpression BEFREE Due to the functions of PGRN in neuronal survival and the clinicopathological overlaps between FTD and other dementias it is likely that reduced PGRN expression is associated with the progression of other neurodegenerative brain diseases including Alzheimer's disease. 17168647

2006

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker LHGDN Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease. 18565828

2008

Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker BEFREE Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease. 18565828

2008