Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE The ADIPOQ rs266729 G/C gene polymorphism is significantly associated with low APN levels and linked to susceptibility to develop cancer. 28529612

2017

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation BEFREE A mutation in aminopeptidase N (CD13) isolated from a patient suffering from leukemia leads to an arrest in the endoplasmic reticulum. 16469741

2006

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.100 GeneticVariation BEFREE These data revealed that most AML with CEBPA mutations were associated with an immunophenotype of HLA-DR(+)CD7(+)CD13(+)CD14(-)CD15(+)CD33(+)CD34(+). 15746035

2005

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 GeneticVariation BEFREE Being peritumoral EpCAM positive was also significantly associated with a larger tumor size, liver cirrhosis, and more frequent vascular invasion; however, no statistically significant association was observed between CD13 and any clinicopathological features. 28572700

2017

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE The ADIPOQ rs266729 G/C gene polymorphism is significantly associated with low APN levels and linked to susceptibility to develop cancer. 28529612

2017

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.090 GeneticVariation BEFREE The aim of the present study was to determine the correlation between adiponectin (APN) gene polymorphism, metabolic syndrome incidence, and degree of atherosclerosis in patients with this disease. 29109761

2017

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.090 GeneticVariation BEFREE The aim of the present study was to determine the correlation between adiponectin (APN) gene polymorphism, metabolic syndrome incidence, and degree of atherosclerosis in patients with this disease. 29109761

2017

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C1658953
Disease: tumor vasculature
tumor vasculature
0.080 GeneticVariation BEFREE Overall, WM15 was the most specific antibody for angiogenic tumor vessels, suggesting that it may be a good tool for detecting the CD13 form associated with the tumor vasculature. 21339174

2011

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.070 GeneticVariation BEFREE Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on cardiovascular disease, but data on the relationship between plasma APN and cancer mortality is exiguous. 29576602

2018

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.060 GeneticVariation BEFREE Increased DNA methylation at cg23161492 was associated with decreased gene expression levels of ANPEP (p = 8.9 × 10(-5)). rs231356-T, which was associated with hypomethylation of cg26963277 (KCNQ1), was associated with a higher odds of diabetes (OR 1.06, p = 1.3 × 10(-5)). 26825526

2016

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia
0.050 GeneticVariation BEFREE A mutation in aminopeptidase N (CD13) isolated from a patient suffering from leukemia leads to an arrest in the endoplasmic reticulum. 16469741

2006

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0011847
Disease: Diabetes
Diabetes
0.040 GeneticVariation BEFREE Increased DNA methylation at cg23161492 was associated with decreased gene expression levels of ANPEP (p = 8.9 × 10(-5)). rs231356-T, which was associated with hypomethylation of cg26963277 (KCNQ1), was associated with a higher odds of diabetes (OR 1.06, p = 1.3 × 10(-5)). 26825526

2016

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0013421
Disease: Dystonia
Dystonia
0.040 GeneticVariation BEFREE LAP1 interacts with torsinA, the protein mutated in DYT1-dystonia. 25425325

2014

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0393593
Disease: Dystonia Disorders
Dystonia Disorders
0.040 GeneticVariation BEFREE LAP1 interacts with torsinA, the protein mutated in DYT1-dystonia. 25425325

2014

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
0.030 GeneticVariation BEFREE Mutations in the p150 subunit of the axonal transport protein dynactin (DCTN1) have been reported in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 17824900

2007

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
0.030 GeneticVariation BEFREE A heterozygous R1101K mutation of the p150 subunit of dynactin (DCTN1) is reported in a family with amyotrophic lateral sclerosis (ALS) and co-occurrence of frontotemporal dementia (FTD). 16240349

2005

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0026850
Disease: Muscular Dystrophy
Muscular Dystrophy
0.030 GeneticVariation BEFREE Conditional deletion of LAP1 from striated muscle causes muscular dystrophy; this pathology is worsened in the absence of emerin. 24055652

2013

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.030 GeneticVariation BEFREE We hypothesized that combined administration of PPARγ agonists and ADRCs may enhance the paracrine effects of adiponectin (APN), leading to functional recovery in a chronic myocardial infarction (MI) model. 30902059

2019

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C4551979
Disease: Nephronophthisis 1
Nephronophthisis 1
0.030 GeneticVariation BEFREE Molecular genetic identification of families with juvenile nephronophthisis type 1: rate of progression to renal failure. APN Study Group. Arbeitsgemeinschaft für Pädiatrische Nephrologie. 8995741

1997

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C4551979
Disease: Nephronophthisis 1
Nephronophthisis 1
0.030 GeneticVariation BEFREE Mapping of a gene for familial juvenile nephronophthisis: refining the map and defining flanking markers on chromosome 2. APN Study Group. 8250041

1993

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0004096
Disease: Asthma
Asthma
0.020 GeneticVariation BEFREE No association was observed between pollutants and urgent asthma among children in HAPN (P > 0.05). 30337671

2019

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.020 GeneticVariation BEFREE <i>Methods</i>: Blood samples from 105 CRC patients (50 women and 55 men) with and without MetS were genotyped for APN rs266729 G/C polymorphism by TETRA ARMS PCR. 28529612

2017

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0338451
Disease: Frontotemporal dementia
Frontotemporal dementia
0.020 GeneticVariation BEFREE Mutations in the p150 subunit of the axonal transport protein dynactin (DCTN1) have been reported in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 17824900

2007

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0338451
Disease: Frontotemporal dementia
Frontotemporal dementia
0.020 GeneticVariation BEFREE A heterozygous R1101K mutation of the p150 subunit of dynactin (DCTN1) is reported in a family with amyotrophic lateral sclerosis (ALS) and co-occurrence of frontotemporal dementia (FTD). 16240349

2005

Entrez Id: 290
Gene Symbol: ANPEP
ANPEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.020 GeneticVariation BEFREE <i>Methods</i>: Blood samples from 105 CRC patients (50 women and 55 men) with and without MetS were genotyped for APN rs266729 G/C polymorphism by TETRA ARMS PCR. 28529612

2017