Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE There was no specific expression of the polypeptide epitope of EGFr observed in any of the colon cancers or normal colon tissues. 2682005

1989

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE DiFi cells showed strong overexpression of the EGFR gene on Northern blots relative to three other colon cancer cell lines examined. 8453634

1993

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation BEFREE KRAS mutation in colon cancer: a marker of resistance to EGFR-I therapy. 19936839

2010

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation BEFREE Mostly, we verified a higher frequency rate of the KRAS(G13) and EGFR A13_del oncogene mutations in right colon cancer; whereas KRAS(G12) codon mutation occurs more frequently in left colon cancers. 23572025

2013

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE In conclusion, caveolin-1 is more expressed in cancer tissues than normal colon and related with Akt-1, not with EGFR expression in colorectal cancer tissues, which suggests that signaling for caveolin-1 affects Akt-1 activation, but this reaction is not initiated by EGFR stimulation in colon cancer. 16202996

2006

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE In the present study, we first determined the expression of miR-20b by RT-PCR and the levels of a disintegrin and metalloprotease 9 (ADAM9) and epidermal growth factor receptor (EGFR) by western blotting in CC and adjacent non-cancerous tissues from 5-FU-sensitive or -resistant CC patients. 27878272

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Phospho-EGFR (Tyr-1173) and EGFR expression were analysed by immunohistochemistry (IHC) in tissue microarrays of TNM stage II and III colon cancers from completed adjuvant therapy trials (n=388). 19997103

2010

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE In order to define proteins involved in potential resistance mechanisms, we examined the effect of gefitinib (ZD1839, Iressa) in the EGFR-positive colon cancer cell lines Caco-2, DiFi, HRT-18 and HT-29. 16115757

2005

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation BEFREE In conclusion, detection of somatic mutations in the epidermal growth factor receptor may play an important role in predicting sensitivity to gefitinib in colon cancer. 18497962

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE To the best of our knowledge, anti-cancer activity of this chimeric protein against colon cancer that overexpresses epidermal growth factor receptor (EGFR) has not yet been studied. 30471512

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Interaction of EGFR and ERCC1 might correlate with radiation-induced DNA damage when p53 mutant colon cancer cell lines are exposed to 5-FU followed by radiation. 18497992

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. 21383692

2011

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR. 22070864

2011

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE EGFR and colon cancer: a clinical view. 18208787

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE To examine whether erlotinib gives similar results to gefitinib, a small molecule epidermal growth factor receptor (HER1/EGFR) tyrosine kinase (TK) inhibitor that inhibits the growth of human bladder cancer cell lines in vitro, and given that interferon-alpha (IFNalpha) promotes an antiproliferative effect of HER1/EGFR inhibitors on colon cancer cell lines, to also determine the effects of erlotinib alone or together with INFalpha on bladder cancer cell lines, and whether sensitivity is influenced by HER1/EGFR mutation status. 17346275

2007

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Down-regulation of epidermal growth factor receptor by selective expansion of a 5'-end regulatory dinucleotide repeat in colon cancer with microsatellite instability. 19584170

2009

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Epidermal growth factor receptor status and persistent activation of Akt and p44/42 MAPK pathways correlate with the effect of cetuximab in head and neck and colon cancer cell lines. 18813952

2009

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Forty-eight-hour treatment of colon cancer HCT-116 and HT-29 cells with FOLFOX resulted in 60-70% survival, accompanied by a marked activation of insulin like growth factor-1 receptor (IGF-1R) and minor to moderate increase in epidermal growth factor receptor (EGFR), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (HER-2) as well as v-akt murine thymoma viral oncogene homolog 1 (AKT), cyclooxygenase-2 (COX-2) and cyclin-D1. 20332435

2010

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE In the present study, we investigated the effects of bile acids on cell signaling and proliferation of a human colon cancer cell line (H508 cells) that abundantly expresses M3R and EGFR. 16139803

2005

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Inhibition of human colon cancer malignant cell behavior and growth by antisense epidermal growth factor receptor expression vector. 9703869

1998

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE These findings indicate that erbB2 and erbB3, but not EGFR, may contribute to tumor growth and disease progression in colon cancer. 9712416

1998

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Furthermore, Sushi-IL15-Apo increased the anti-tumor effect of a murine anti-EGFR mAb in Rag1<sup>-/-</sup> mice bearing subcutaneous MC38 colon cancer transfected to express EGFR. 29308327

2018

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Y‑box‑binding protein 1 inhibits apoptosis and upregulates EGFR in colon cancer. 30864697

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Antibody-dependent cell-mediated cytotoxicity (ADCC) significantly contributes to the anti-tumor effects of monoclonal antibodies, including cetuximab, an epidermal growth factor receptor (EGFR)-targeted monoclonal antibody that is frequently added to chemotherapy in the treatment of colon cancer. 30090970

2018

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE High expression of EGFR might predict poor survival for patients with colon cancer. 23387315

2013