Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.010 Biomarker BEFREE These included proteins already studied in the context of CVD (such as apolipoprotein B, alpha-2-macroglobulin), as well as novel findings (such as low density lipoprotein receptor related protein 2 [LRP2], protein SZT2) for which a mechanism of action is suggested. 29665821

2018

Entrez Id: 100329167
Gene Symbol: AAA1
AAA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.010 GeneticVariation BEFREE In weighted Cox regression models, we found that baseline lysine (HR<sub>+1 SD increase</sub> = 1.26; 95% CI 1.06-1.51) and 2-AAA (HR<sub>+1 SD increase</sub> = 1.28; 95% CI 1.05-1.55) were both associated with a higher risk of T2D, but not with CVD. 31722714

2019

Entrez Id: 8086
Gene Symbol: AAAS
AAAS
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.010 GeneticVariation BEFREE In weighted Cox regression models, we found that baseline lysine (HR<sub>+1 SD increase</sub> = 1.26; 95% CI 1.06-1.51) and 2-AAA (HR<sub>+1 SD increase</sub> = 1.28; 95% CI 1.05-1.55) were both associated with a higher risk of T2D, but not with CVD. 31722714

2019

Entrez Id: 79719
Gene Symbol: AAGAB
AAGAB
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019

Entrez Id: 17
Gene Symbol: AAVS1
AAVS1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.010 Biomarker BEFREE The advances made in each mode of intervention as well as the ones that are beyond the scope of AAV gene therapy or has not been approached through AAV gene therapy as of now have been provided in detail to illustrate the bigger picture of where we stand to combat cardiovascular diseases most efficiently. 28589503

2017

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 GeneticVariation BEFREE DNA methylation at the ATP-binding cassette transporter A1 (ABCA1) gene was previously associated with CVD, but whether these epigenetic marks respond to changes in the maternal environment is unknown. 24113149

2013

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE ApoA-I and ABCA1 play important roles in nascent HDL (nHDL) biogenesis, the first step in the pathway of reverse cholesterol transport that protects against cardiovascular disease. 30249788

2019

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE ATP binding cassette transporter 1 (ABCB1) plays a critical role in the development and progression of cardiovascular disease. 25118983

2014

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE Multiple factors related to lipid metabolism and other processes modulate expression and tissue distribution of ABCA1.Therefore, as the primary gatekeeper for eliminating tissue cholesterol, ABCA1 has a major impact on cellular and whole body cholesterol metabolism and is likely to play an important role in protecting against cardiovascular disease. 11483617

2001

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE Moreover, oxidative modifications of HDL found in patients with cardiovascular disease reduce the ability of apolipoproteins to remove cellular cholesterol by the ABCA1 pathway. 16183915

2005

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 GeneticVariation BEFREE Decreased frequencies of ABCA1 polymorphisms R219K and V771M in Hungarian patients with cerebrovascular and cardiovascular diseases. 16446539

2006

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 GeneticVariation BEFREE In the C-terminal part of ABCA1, known to interact with other proteins, two novel sequence variations (F2163S and V2244I) have been found in one phenotype related to cardiovascular disease, but none in the aforementioned cohorts. 15262183

2004

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE Recent studies underscore the critical role of ABCA1 in clearing excess cholesterol from macrophages and generating HDL particles, implicating ABCA1 as an attractive new therapeutic target for treating cardiovascular disease. 12151852

2002

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 AlteredExpression BEFREE Studies of Tangier disease heterozygotes revealed that the relative activity of ABCA1 determines plasma HDL levels and susceptibility to CVD. 11227043

2001

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 PosttranslationalModification BEFREE Although this study does not prove causality, the results suggest that ABCA1 DNA methylation mediates the protective effect of VC on HDL cholesterol in women, which could offer a novel biological mechanism in CVD prevention. 31504085

2019

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE The ABCA1 pathway has therefore become a promising new therapeutic target for treating cardiovascular disease and diabetes. 19344785

2009

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE However, the impact of ABCA1 on recurrent cardiovascular disease in a secondary prevention setting is as of yet unknown. 21840005

2011

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 AlteredExpression BEFREE Of particular importance for CVD, inhibition of miR-148a may prove an important therapeutic approach for combating dyslipidemia, as this has been demonstrated to both raise plasma HDL levels and lower LDL levels in mice by targeting both ABCA1 and LDLR, respectively. 26828754

2016

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE The identification of ABC1 as the TD locus has implications for the understanding of cellular HDL metabolism and reverse cholesterol transport, and its association with premature cardiovascular disease. 10431237

1999

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 AlteredExpression BEFREE Because of its ability to deplete cells of cholesterol and to raise plasma HDL levels, ABCA1 has become a promising therapeutic target for preventing cardiovascular disease. 16235041

2005

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE These results show a direct relation between ABCA1-mediated cellular cholesterol efflux and arterial-wall thickness, and therefore suggest that increasing efflux could inhibit atherosclerosis progression before the manifestation of symptomatic cardiovascular disease. 11809185

2002

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE Using genetic and biochemical approaches, we investigated proteins that regulate macrophage cholesterol efflux capacity (CEC) and ABCA1-specific CEC (ABCA1 CEC), 2 functional assays that predict cardiovascular disease (CVD). 28768900

2017

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE This makes ABCA1 a promising new therapeutic target for reducing cholesterol deposits in tissues, eliminating excess cholesterol from the body, and preventing cardiovascular disease. 12069757

2002

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE These observed anti-diabetic actions suggest additional benefits of the CS6253 and T6991-2 ABCA1 peptide agonists for cardiovascular disease beyond their direct anti-atherosclerosis properties previously described. 30290217

2019

Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker BEFREE ATP-binding cassette transporter 1 (ABCB1) plays a critical role in the development and progression of cardiovascular disease. 24328528

2014