Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Kras activation and Pten deletion are observed in intestinal-type gastric cancer, and Cdh1 mutation is associated with diffuse-type gastric cancer. 30168144

2019

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE The -472delA (rs5030625) and -160C>A (rs16260) polymorphisms in CDH1 induce a decrease in gene transcription; in fact, these mutated alleles have been associated with GC in some populations, with conflicting results. 27706737

2016

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Gastric cancer (GC) is considered to be one of the leading cancers in East Asians, and mutations in the CDH1 gene and the reduced expression of E-cadherin are the most frequent genetic alterations in gastric cancer. 23435907

2013

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Familial diffuse type gastric cancer occurs due to germ-line mutations of the CDH1 gene. 16273224

2005

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE The poorly cohesive histology/CDH1-mutant GC subgroup showed the worst survival (p < 0.001). 30801717

2019

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Inactivation of the E-cadherin gene in sporadic diffuse-type gastric cancer. 11598162

2001

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 Biomarker BEFREE A great number of genes with promoter methylation have been observed in gastric cancer (GC), among which p16INK4A (p16), Mut L homologue 1 (MLH1), Epithelial-cadherin (E-cadherin), Runt-related transcription factor 3 (RUNX3), adenomatous polyposis coli (APC), O(6)-methylguanine-DNA methyltransferase (MGMT), Ras association domain family 1A (RASSF1A) and Death-associated protein kinase (DAPK) have been extensively studied. 22936446

2012

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Analysis of HDGC patients harbouring CDH1 alleles with PTCs at a wide variety of different positions indicates an association of their predicted ability to induce NMD and an earlier age of onset of gastric cancer. 18427545

2008

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE No associations between CDH1 (+54T>C, -160C>A, -347G>GA, -616G>C, -2076C>T and -3159T>C) gene polymorphisms and GC risk for all genetic models were found. 21570316

2011

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE We have shown that germline CDH1 mutations are associated with early onset of bilateral LCIS with or without ILC in women without a family history of gastric cancer. 24366306

2014

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 PosttranslationalModification BEFREE CDH1 gene promoter hypermethylation in gastric cancer: relationship to Goseki grading, microsatellite instability status, and EBV invasion. 16531765

2006

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE All individuals with a CDH1 mutation had a personal or family history of diffuse gastric cancer. 26072394

2015

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 PosttranslationalModification BEFREE E-cadherin promoter hypermethylation induced by interleukin-1beta treatment or H. pylori infection in human gastric cancer cell lines. 18249489

2008

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 Biomarker BEFREE CDH1 associated gastric cancer: a report of a family and review of the literature. 15780560

2005

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Hereditary diffuse gastric cancer is caused by germline mutations in the epithelial cadherin (CDH1) gene and is characterized by an increased risk for diffuse gastric cancer and lobular breast cancer. 17545690

2007

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE In our area, in which a high rate of familial aggregation was demonstrated, the lack of germ line mutation of TP53 together with the infrequency of mutation of E-cadherin gene seem to limit the role of genetic predisposition in the development of gastric cancer. 19674071

2010

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Furthermore, the CDH1 c.1679C>G (p.T560R) variant segregated with gastric cancer in all three family members affected with gastric cancer in this family. 27880784

2016

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE CIHM of CDH1 and DAP-kinase in non-neoplastic gastric mucosa corresponded to a risk of GC regardless of histological subtype, H. pylori infection status, gender and generation. 20150736

2010

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE We screened all exons of the E-cadherin gene for mutations in 101 Japanese patients having an intense family history of gastric cancers. 12604719

2003

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Endoscopic Ultrasound Has Limited Utility in Diagnosis of Gastric Cancer in Carriers of CDH1 Mutations. 31077828

2020

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Using polymerase chain reaction (PCR)/single-strand conformation polymorphism (SSCP)/sequencing, we screened 32 Portuguese families with a history of gastric cancer and 23 patients with early onset gastric cancer for CDH1 germline mutations. 15288293

2004

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 AlteredExpression BEFREE The E-cadherin protein expression level in gastric cancer tissues was significantly lower than that in the adjacent normal tissues (p < 0.05). 22581441

2012

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Overall, 78% of GC cases harbored one clinically relevant GA or more, with the most frequent alterations being found in TP53 (50%), ARID1A (24%), KRAS (16%), CDH1 (15%), CDKN2A (14%), CCND1 (9.5%), ERBB2 (8.5%), PIK3CA (8.6%), MLL2 (6.9%), FGFR2 (6.0%), and MET (6.0%). 25882375

2015

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE CDH1 germ-line missense mutation identified by multigene sequencing in a family with no history of diffuse gastric cancer. 25981591

2015

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE These results suggest that the ATCTG and CTTTG CDH1 haplotypes may be associated with an increased risk and decreased risk, respectively, of GC in the Japanese population. 17852867

2007