Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.080 Biomarker BEFREE The purpose of this study is to evaluate the effects of the combination, cyclooxygenase-2 inhibitor and docetaxel, on epithelial ovarian cancer cells. 17667594

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.080 AlteredExpression BEFREE The aim of this study was to investigate the potential prognostic value of COX2 and HER2 expression in EOC. 17309668

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.080 Biomarker BEFREE Our in vitro data using EOC cell line showed that inhibition of COX-2 by aspirin, selective inhibitor NS398 and gene silencing by COX-2 specific siRNA impaired phosphorylation of AKT resulting decreased downstream signaling leading to cell growth inhibition and induction of apoptosis. 19621391

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.080 AlteredExpression BEFREE Blueberries inhibit cyclooxygenase-1 and cyclooxygenase-2 activity in human epithelial ovarian cancer. 28599493

2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.080 Biomarker BEFREE These results suggest that COX-2-Snail signaling plays a critical role in regulation of E-cadherin and might provide insights into mechanisms for paracrine inflammation-mediated aggressiveness in EOC. 29932878

2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.080 Biomarker BEFREE The Expression of HSD17B12 Is Associated with COX-2 Expression and Is Increased in High-Grade Epithelial Ovarian Cancer. 29324448

2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.080 Biomarker BEFREE Several reports have shown that treatment of EOC cells with COX-1- and COX-2-specific inhibitors exhibits a therapeutic effect on EOC both in vitro and in vivo. 29727350

2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.080 Biomarker BEFREE Thus, inhibition COX-2/PGE2 signaling will likely be beneficial in the treatment of EOC. 31817839

2019