Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE <b>Background:</b> rs9357347 located at the triggering receptor expressed on myeloid cells (<i>TREM</i>) gene cluster could increase TREM2 and TREM-like transcript 1 (TREML1) brain gene expression, which is considered to play a protective role against Alzheimer's disease (AD). 31379492

2019

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE <b>Results:</b> 3xTg-AD mice dosed orally with MSX have decreased expression of several inflammatory proteins, including, most notably, the AD risk-associated protein 'triggering receptor expressed on myeloid cells-2' (TREM2), and stimulator of interferon genes TMEM173, and suppressor of cytokine signaling-6 (SOCS6). 31583972

2019

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE (2017) recently reported that mutations in TREM2, a protein implicated in AD, disrupt microglial energy state and function, thus sabotaging the microglia's ability to defend the brain against amyloid plaques. 28978423

2017

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE (2019) demonstrate opposing effects of CD33 and TREM2 on AD phenotypes, where CD33 deletion promotes neuroprotection in a manner dependent on TREM2. 31487521

2019

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE TREM2 in Alzheimer's disease. 23407992

2013

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE TREM2 and the neuroimmunology of Alzheimer's disease. 24355566

2014

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE TREM2 is an innate immune receptor that regulates microglial cytokine production and phagocytosis, implying that dysregulation of these processes may be involved in AD pathology, with implications for disease management. 25260849

2015

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE TREM2 is associated with increased risk for Alzheimer's disease in African Americans. 25886450

2015

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE TREM2 variants: new keys to decipher Alzheimer disease pathogenesis. 26911435

2016

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 AlteredExpression BEFREE TREM2 mRNA levels are increased in the human hippocampus in AD cases compared to controls. 27051467

2016

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 AlteredExpression BEFREE TREM2 is a transmembrane protein involved in innate immunity and is selectively expressed by microglia and genetically linked to AD and other neurodegenerative disorders. 27974666

2016

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 AlteredExpression BEFREE TREM2 was significantly upregulated in sAD frontal cortex but stable in hippocampus. 28365005

2017

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 AlteredExpression BEFREE TREM2 mRNA levels were significantly higher in AD compared to controls and aMCI. 28453482

2017

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE TREM2 mutations are genetically linked to Nasu-Hakola disease and associated with multiple neurodegenerative disorders, including Alzheimer's disease. 28490631

2017

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE TREM2 is shed by proteases of the ADAM (a disintegrin and metalloproteinase domain containing protein) family C-terminal to histidine 157, a position where an AD-associated coding variant has been discovered (p.H157Y) in the Han Chinese population. 28855300

2017

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE TREM2 (triggering receptor expressed on myeloid cells 2) induced APOE signaling, and targeting the TREM2-APOE pathway restored the homeostatic signature of microglia in ALS and AD mouse models and prevented neuronal loss in an acute model of neurodegeneration. 28930663

2017

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor and could decrease neuropathology in Alzheimer's disease (AD). 29180839

2017

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE TREM2 rare protein coding genetic variants have been linked to AD. 29685286

2018

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Triggering receptor expressed on myeloid cells 2 (TREM2) activates the innate immune system, promotes phagocytosis by microglia, and is associated with Alzheimer's disease (AD). 30010135

2018

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE TREM2 variants associated with Alzheimer's disease induce partial loss of function of the TREM2 protein and alter the behaviour of microglial cells, including their response to amyloid plaques. 30033062

2018

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE TREM2 can serve as a potential therapeutic target for treating systemic inflammation in AD progression. 30756214

2019

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease. 31301936

2019

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE TREM2 plays a critical role in microglial activation, survival, and phagocytosis; however, the pathophysiological role of sTREM2 in AD is not well understood. 31413141

2019

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor that mediates the degradation disorder of amyloid β (Aβ) in Alzheimer's disease. 31833018

2020

Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE A comprehensive understanding of TREM2 function in the pathogenesis of AD offers a unique opportunity to explore the potential of this microglial receptor as an alternative target in AD therapy. 30532704

2018