Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation BEFREE With the purpose to evaluate the association between LIN28B gene polymorphisms and neuroblastoma susceptibility in Southern Chinese population, we conducted this study with 256 neuroblastoma cases and 531 cancer-free controls. 27021521

2016

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 AlteredExpression BEFREE We show that MYCN regulates LIN28B expression in neuroblastoma tumors via two distinct parallel mechanisms. 26123663

2015

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 AlteredExpression BEFREE By this study, a regulatory loop is proposed, wherein, ODC silencing in Y79 cells to result in decreased polyamine levels, thereby, leading to altered protein levels of Lin28b, MMP-2 and MMP-9, which falls in line with earlier studies in neuroblastoma. 29241071

2018

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation BEFREE We also found that the combination of polymorphisms in CASC15, LIN28B, and LMO1 may be used to predict neuroblastoma risk (AUC=0.63, 95% CI=0.59-0.67). 29024823

2017

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 AlteredExpression BEFREE In vitro experiments using NB cell lines, BE(2)-C, SMS-KCNR, and CHLA90 show that DFMO treatment reduced LIN28B and MYCN protein levels and increased Let-7 miRNA and decreased neurosphere formation. 25415050

2015

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation BEFREE Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression. 22941191

2012

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation BEFREE In a genome-wide association study, we identified single-nucleotide polymorphisms (SNP) associated with neuroblastoma at the CASC15, BARD1, LMO1, DUSP12, HSD17B12, HACE1, and LIN28B gene loci, but these explain only a small fraction of neuroblastoma heritability. 25312269

2014

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation BEFREE Several neuroblastoma (NB) susceptibility loci have been identified within LINC00340, BARD1, LMO1, DUSP12, HSD17B12, DDX4, IL31RA, HACE1 and LIN28B by genome-wide association (GWA) studies including European American individuals. 23222812

2013

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 AlteredExpression BEFREE The results also establish that LIN28B overexpression supports neuroblastoma onset and the metastatic potential of malignant cells through let-7a-dependent and let-7a-independent mechanisms. 31601998

2020

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 Biomarker BEFREE Here we show, however, that LIN28B is dispensable in MYCN-amplified neuroblastoma cell lines, despite de-repression of let-7. 27383785

2016

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 AlteredExpression BEFREE These findings were fully recapitulated in a mouse model in which LIN28B expression in the sympathetic adrenergic lineage induced development of neuroblastomas marked by low let-7 miRNA levels and high MYCN protein expression. 23042116

2012

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 Biomarker BEFREE We set out to determine whether the analysis of TH (tyrosine hydroxylase), PHOX2B (paired-like homeobox 2b), and DCX (doublecortin) transcripts using quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) could be used to detect NB contamination in ovarian tissue. 27734578

2017

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 AlteredExpression BEFREE Furthermore, it has been observed that neuronal differentiation in neuroblastoma is dependent on down-regulation of <i>PHOX2B</i> expression, which confirms that PHOX2B expression may be considered a target in neuroblastoma. 29069774

2017

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 GeneticVariation BEFREE For instance, discoveries in familial NBL have identified genetic aberrations in Phox2b and Alk that predispose to NBL, while advances in epigenetics and MYCN regulation have also offered insight into NBL pathogenesis and future treatment. 21922652

2012

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 GeneticVariation BEFREE We did not find any conclusive association of the polymorphisms or mutations in PHOX2b with the development of NB, although the large confidence intervals neither substantiate nor exclude a role for this gene in the tumor etiology. 19011468

2008

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 AlteredExpression BEFREE Therefore, post-transcriptional down-regulation of the PHOX2B gene takes place in NB cell lines and miRNA-204 participates in such a 3'UTR mediated control. 26145533

2015

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 AlteredExpression BEFREE In the present study, we validated the ability of 14 commonly used real-time RT-PCR markers to detect MRD based on their expression in neuroblastoma TICs, and we developed a novel MRD detection protocol, which scored the samples as MRD-positive when the expression of one of the 11 real-time RT-PCR markers (CHRNA3, CRMP1, DBH, DCX, DDC, GABRB3, GAP43, ISL1, KIF1A, PHOX2B and TH) exceeded the normal range. 23417100

2013

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 GeneticVariation BEFREE We also report a germline PHOX2B mutation in one patient treated for Hirschsprung's disease who subsequently developed a multifocal neuroblastoma in infancy. 15949893

2005

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 Biomarker BEFREE In neuroblastoma (NB) patients, minimal residual disease (MRD) can be detected by real-time quantitative PCR (qPCR) using NB-specific target genes, such as PHOX2B and TH. 22251610

2012

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 Biomarker BEFREE Positive immunostaining of NCSC (GAP43, c-kit, NF68, vimentin and Phox2b) and undifferentiated cell (ABCG2) markers was observed in all NB subtypes. 19216736

2009

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 Biomarker BEFREE The PHOX2B gene is implicated in the development of the autonomic nervous system and has been found to be infrequently mutated in sporadic neuroblastoma tumours and in some patients with hereditary neuroblastoma. 18292934

2008

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 GeneticVariation BEFREE Recent studies have shown that 1) PHOX2B is the main disease-causing gene for congenital central hypoventilation syndrome, an autosomal dominant disorder with incomplete penetrance; 2) PHOX2B is the first gene for which germline mutations have been demonstrated to predispose to neuroblastoma; and 3) Hirschsprung disease was associated with an intronic single-nucleotide polymorphism of the PHOX2B gene in a case-control study. 15901893

2005

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 GeneticVariation BEFREE This case highlights the need to consider neuroblastoma in patients with CCHS and the longest PHOX2B PARMs and to individualize treatment based on co-morbidities. 26011159

2015

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 Biomarker BEFREE Transient transfections and electrophoretic-mobility-shift assays suggested that PHOX2B is able to bind the cell-specific element in the 5' regulatory region of the TLX2 gene, determining its transactivation in neuroblastoma cells. 16402914

2006

Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.800 AlteredExpression BEFREE Starting from these observations, we have performed in vitro drug screening approaches targeting PHOX2B overexpression as a potential pharmacological means in NB. 25882494

2015