Several human ovarian and cervical cancer cell lines spontaneously express the icIL-1Ra. icIL-1Ra-expressing cells did not have altered growth characteristics or altered short term responses to IL-1 compared with icIL-1Ra-nonexpressing cells.
Our results indicated that IL-1RN A2 allele is associated with an increased susceptibility to cervical cancer development, probably by increasing predisposition to shorter immune responses.
Fourteen studies testing the association between IL-1β and/or IL-1RN gene polymorphisms and cervical cancer were examined: 5 studies of IL-1β-511C/T, 3 studies of IL-1β-31T/C, and 6 studies of IL-1RN.
The meta-analysis suggests that the CTLA-4 +49 A/G and IL-1B -511 C/T polymorphisms are associated with cervical cancer in East Asians, and that the IL-1RN VNTR polymorphism is associated with cervical cancer in Indians.