Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression BEFREE The study supports the hypothesis that an impaired control of glycogen synthase kinase-3beta activity by insulin receptor-mediated signalling plays a role in the pathogenesis of AD, facilitating tau protein phosphorylation and neurofibrillary tangle formation. 17986027

2007

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression BEFREE Furthermore, postmortem analyses of brains from patients with AD revealed a markedly downregulated expression of insulin receptor (IR), IGF-1 receptor (IGF-1R), insulin receptor substrate (IRS)-1 and IRS-2, and these changes progress with severity of neurodegeneration. 19519303

2009

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression BEFREE Our results suggest that the difference in IR binding and effect on protein expression downstream of the IR may affect onset and progression of AD. 29450841

2018

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression BEFREE Combination of Insulin with a GLP1 Agonist Is Associated with Better Memory and Normal Expression of Insulin Receptor Pathway Genes in a Mouse Model of Alzheimer's Disease. 30635783

2019

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Insulin and the IR are also present in the brain, and since there is evidence that neuronal insulin signaling regulates synaptic plasticity and that it is impaired in disease, this pathway might be the key to protection or reversal of symptoms, especially in Alzheimer's disease. 27889917

2017

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Corrigendum: Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease. 31823898

2020

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression BEFREE Since IR expression is diminished in type-2 diabetes as well as in Alzheimer's disease (AD) patients, these data may provide a mechanistic link between insulin resistance, impaired synaptic transmission and cognitive decline in humans with metabolic disorders. 22661254

2012

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Insulin receptor pathology is an important feature of AD brains that impairs the neuroprotective actions of central insulin signaling. 29435980

2018

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Reported evidence shows that vascular risk factors are associated with AD, particularly in the development of protein aggregation, inflammation, oxidative stress, neuronal dysfunction, and disturbances in signaling pathways, with insulin receptor signaling being a common alteration between MetS and AD. 27368351

2017

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease? 28470423

2017

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Here, we show that microRNA 7 (miR-7), an abundant microRNA in the brain, targets insulin receptor (INSR), insulin receptor substrate 2 (IRS-2), and insulin-degrading enzyme (IDE), key regulators of insulin homeostatic functions in the central nervous system (CNS) and the pathology of AD. 31501273

2019

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression BEFREE However, when the samples were analyzed separately according to the region of the brain, there was a significant upregulation of INSR expression in the hippocampus and the entorhinal cortex in the AD patient group. 28164769

2017

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Disturbances of brain glucose uptake, glucose tolerance, glucose utilization and of the insulin/insulin receptor signaling cascade are thought to be key features of the pathophysiology of AD. 26268335

2016

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Defective insulin receptor signalings are associated with the dementia in normal aging and patients with age-related neurodegenerative diseases (e.g., Alzheimer's disease); the cognitive impairment can be reversed with systemic administration of insulin in the euglycemic condition. 16210778

2005

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Regulation of Aβ production by glucose and insulin and effects of Aβ on the insulin receptor pathway suggest similar cellular mechanisms may exist between neuronal dysfunction in Alzheimer disease and adipose dysfunction in type 2 diabetes. 27172814

2016

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Evidence for altered insulin receptor signaling in Alzheimer's disease. 29353052

2018

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Following these discoveries, evidence of decreased brain insulin receptor number and function was reported in both clinical samples and animal models of aging and Alzheimer's disease, setting the stage for the hypothesis that neuronal insulin resistance may underlie memory loss in these conditions. 30576640

2019

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression BEFREE Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer's disease and normalized by treatment with anti-diabetic agents. 30383799

2018

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE To define the role of IR in this context, we crossed neuron-specific IR knockout mice (nIR(-/-)) with Tg2576 mice, a well-established mouse model of an AD-like pathology. 22057897

2013

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE The cross-talk between NGF and insulin pathways downstream the insulin receptor suggests novel potential therapeutic targets to slow cognitive decline in AD and diabetes-related brain insulin resistance. 29736736

2019

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 AlteredExpression BEFREE Alzheimer's disease (AD) is associated with reduced insulin level and impairment of insulin receptor (IR) signaling in the brain, which correlates to amyloid pathology, neuroinflammation, and synaptic neurotoxicity. 27730514

2017

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Insulin receptor dysfunction has been associated with many diseases, including diabetes, cancer and Alzheimer's disease. 29512653

2018

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease. 30964050

2019

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Brain protein O-GlcNAcylation is diminished in Alzheimer's disease (AD), and OGT targets include proteins of the insulin-signaling pathway (e.g., insulin receptor susbtrate-1, IRS-1). 29154269

2018

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker BEFREE Alzheimer's disease (AD) is associated with progressive impairments in brain insulin, insulin-like growth factor (IGF), and insulin receptor substrate (IRS) signaling through Akt pathways that regulate neuronal growth, survival, metabolism, and plasticity.The intracerebral streptozotocin (i.c. 27802237

2017