Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.700 CausalMutation CGI

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.500 GeneticVariation UNIPROT

Entrez Id: 5156
Gene Symbol: PDGFRA
PDGFRA
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 CausalMutation CGI

Entrez Id: 1616
Gene Symbol: DAXX
DAXX
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.330 CausalMutation CGI

Entrez Id: 7052
Gene Symbol: TGM2
TGM2
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.340 Biomarker CTD_human Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. 17099729

2007

Entrez Id: 7052
Gene Symbol: TGM2
TGM2
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.340 Therapeutic CTD_human Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. 17099729

2007

Entrez Id: 7490
Gene Symbol: WT1
WT1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.350 Biomarker CTD_human Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression. 20820871

2011

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker CTD_human A cDNA-microarray analysis of camptothecin resistance in glioblastoma cell lines. 16356833

2006

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker CTD_human A cDNA-microarray analysis of camptothecin resistance in glioblastoma cell lines. 16356833

2006

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker CTD_human A cDNA-microarray analysis of camptothecin resistance in glioblastoma cell lines. 16356833

2006

Entrez Id: 902
Gene Symbol: CCNH
CCNH
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.300 Biomarker CTD_human Among them, the CCNH-C5orf30 and TRMT11-GRIK2 gene fusions were found in breast cancer, colon cancer, non-small cell lung cancer, esophageal adenocarcinoma, glioblastoma multiforme, ovarian cancer and liver cancer, with frequencies ranging from 12.9% to 85%. 30705370

2019

Entrez Id: 90355
Gene Symbol: MACIR
MACIR
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.300 Biomarker CTD_human Among them, the CCNH-C5orf30 and TRMT11-GRIK2 gene fusions were found in breast cancer, colon cancer, non-small cell lung cancer, esophageal adenocarcinoma, glioblastoma multiforme, ovarian cancer and liver cancer, with frequencies ranging from 12.9% to 85%. 30705370

2019

Entrez Id: 60487
Gene Symbol: TRMT11
TRMT11
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.300 Biomarker CTD_human Among them, the CCNH-C5orf30 and TRMT11-GRIK2 gene fusions were found in breast cancer, colon cancer, non-small cell lung cancer, esophageal adenocarcinoma, glioblastoma multiforme, ovarian cancer and liver cancer, with frequencies ranging from 12.9% to 85%. 30705370

2019

Entrez Id: 2898
Gene Symbol: GRIK2
GRIK2
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.300 Biomarker CTD_human Among them, the CCNH-C5orf30 and TRMT11-GRIK2 gene fusions were found in breast cancer, colon cancer, non-small cell lung cancer, esophageal adenocarcinoma, glioblastoma multiforme, ovarian cancer and liver cancer, with frequencies ranging from 12.9% to 85%. 30705370

2019

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Therapeutic CTD_human Cisplatin restores TRAIL apoptotic pathway in glioblastoma-derived stem cells through up-regulation of DR5 and down-regulation of c-FLIP. 21877938

2011

Entrez Id: 23476
Gene Symbol: BRD4
BRD4
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.320 Biomarker CTD_human EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling. 26455392

2015

Entrez Id: 1513
Gene Symbol: CTSK
CTSK
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.350 Biomarker CTD_human Expression analysis of all protease genes reveals cathepsin K to be overexpressed in glioblastoma. 25356585

2014

Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.310 Biomarker CTD_human Expression of alternatively terminated unusual human butyrylcholinesterase messenger RNA transcripts, mapping to chromosome 3q26-ter, in nervous system tumors. 2317787

1990

Entrez Id: 1848
Gene Symbol: DUSP6
DUSP6
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.310 Biomarker CTD_human Functional assays were performed with adenovirus-mediated expression of DUSP6 in glioblastoma cultures. 21499306

2011

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker CTD_human Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion. 12811834

2003

Entrez Id: 5747
Gene Symbol: PTK2
PTK2
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.370 Biomarker CTD_human Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion. 12811834

2003

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker CTD_human Glioblastoma formation from cell population depleted of Prominin1-expressing cells. 19718438

2009

Entrez Id: 648
Gene Symbol: BMI1
BMI1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker CTD_human GSK3beta regulates differentiation and growth arrest in glioblastoma. 19823589

2009

Entrez Id: 4194
Gene Symbol: MDM4
MDM4
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker CTD_human HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea. 20472715

2010

Entrez Id: 2195
Gene Symbol: FAT1
FAT1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.330 Biomarker CTD_human Here, we report recurrent somatic mutations of the Drosophila melanogaster tumor suppressor-related gene FAT1 in glioblastoma (20.5%), colorectal cancer (7.7%), and head and neck cancer (6.7%). 23354438

2013