|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Oct4, an important transcription factor, is highly expressed in several tumors and promotes the colony-forming ability of cancer cells.
|
21674242 |
2011 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Oct4 mediates tumor initiating properties in oral squamous cell carcinomas through the regulation of epithelial-mesenchymal transition.
|
24475251 |
2014 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Oct 4 expression was significantly higher in poorly differentiated (PDSCC) and basaloid (BSCC) subtypes than the other better differentiated tumor morphology.
|
24870750 |
2014 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
OCT4 plays a critical role in the maintenance of stem cell pluripotency and proliferation, and is overexpressed in multiple human tumors, including endometrial cancer.
|
25634023 |
2015 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
A single colony exhibited 42% occurrence of tumors with higher proliferation capacities. rG2-DC-1C showed continuous expression of the OCT4 stemness gene and of representative tumor markers, potentiated chemoresistance characteristics, and invasion activities.
|
27341307 |
2016 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Accordingly, LKB1-null breast cancer cells exhibited an increased ability to form mammospheres and elevated expression of pluripotency-factors (Oct4, Nanog and Sox2), properties also observed in spontaneous tumors in Lkb1<sup>-/-</sup> mice.
|
28581518 |
2017 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
AFMSCs exhibited positive OCT4 expression and were not observed to induce tumor development in nude mice.
|
28849231 |
2017 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
After the treatment period, the tumor tissues were weighed and harvested for mRNA and protein isolation. qPCR and Western blotting were used to evaluate the expression of cancer stemness markers (epithelial cell adhesion molecule [EpCAM], cluster of differentiation [CD13], CD90, aldehyde dehydrogenase 1 [ALDH1], CD44, and CD45), totipotency factors (sex determining region Y-box 2 [Sox2], Nanog, and octamer-binding transcription factor 4 [Oct4]), and genes involved in the Notch, Wnt/<i>β</i>-catenin, Hedgehog, and Hippo signaling pathways.
|
31341493 |
2019 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
All cell lines were positive for Oct3/4 and nucleostemin; NSTS-11 cells were also able to form xenograft tumors in mice.
|
22156015 |
2011 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
All germinomas coexpressed Oct4 and Kit but showed an extensive global DNA demethylation compared to other tumors and normal tissues.
|
27391150 |
2016 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Altogether, our data highlights an unprecedented role for OCT4 as central regulator of mitotic fidelity and RB tumor suppressor pathway activity.
|
28319064 |
2017 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Based on the results of present study and published reports showing the presence of pluripotent markers (OCT-4, NANOG and SOX2) in human myometrial side population and expression of particularly OCT-4A in human leiomyomas, we speculate that these nuclear OCT-4 positive stem cells located in the perimetrium are the possible tumor initiating cells leading to the development of leiomyomas rather than the mesenchymal cells which express cytoplasmic OCT-4B.
|
28438190 |
2017 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Between Oct 4, 2012, and July 11, 2014, we screened 741 patients with any tumour type.
|
26342236 |
2015 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Cells treated with 5-FU also exhibited tumorigenic potential, based on tumor formation assays in nude mice, and Oct3/4-positive cell aggregates were identified in the resulting tumors.
|
23216104 |
2013 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Clonal populations derived from a single Oct-4/GFP(+) cell were capable of forming tumors heterogeneous for Oct-4/GFP expression.
|
19584295 |
2009 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Comparative studies of OCT4 in adenocarcinoma and BAC tumor cell cultures demonstrated a dramatically higher expression in the former.
|
19126554 |
2009 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Compared with the empty plasmid group and STAT3 low expression group, the mRNA and protein expression of markers of stem cells, OCT4, SOX2 and NANOG were significantly elevated in the STAT3 overexpression group with statistically significant differences (P<0.05), the formation ratio of tumor spheres in the STAT3 overexpression group was also significantly higher than those in the other two groups (P<0.05).
|
28781654 |
2017 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Considering the link between EMT and cancer stem cells, we show that PARP3 promotes stem-like cell properties in mammary epithelial and breast cancer cells by inducing the expression of the stem cell markers SOX2 and OCT4, by increasing the proportion of tumor initiating CD44high/CD24low population and the formation of tumor spheroid bodies, and by promoting stem cell self-renewal.
|
27579892 |
2016 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Expression of Oct4 in tumorospheres might indicate the presence of a population of ECSCs and its expression in xenograft tumors suggests that Oct4 is also associated with tumor metastasis.
|
21547540 |
2011 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Expression of master transcriptional regulators of stem cells (Oct4 and Sox2) is associated with mediating tumor proliferation and tumor differentiation.
|
31115051 |
2019 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Expression regulation of OCT3/4 has been extensively studied in murine and human cell lines, including embryonic stem cell lines and tumor derived cell lines.
|
17549357 |
2007 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Finally, we could also validate that Oct4 and Nanog are regulated by MACC1 in vitro and strongly correlate with MACC1 levels in a cohort of 60 tumors of colorectal cancer patients (r = 0.7005 and r = 0.6808, respectively; P > 0.0001 and P > 0.0002, respectively).
|
26758557 |
2016 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Finally, we examined the correlation between HER2 status and stem cell-related genes expression in human ovarian tumor tissues, and found that expressions of OCT4, COX2, and Nanog were higher in HER2 positive tumors than in HER2 negative tumors.
|
30314995 |
2019 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
From this new knowledge, new markers, eg, FGF4, CD30, and OCT-4, of embryonal carcinoma cells are identifying alternative ways of identifying poor risk tumors and leading to renewed interest in study of histopathology of these tumors.
|
10328600 |
1999 |
|
POU5F1P3
|
Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Functionally, the gain and loss-of-functional experiments revealed that LINC00511 promoted the proliferation, sphere-formation ability, stem factors (Oct4, Nanog, SOX2) expression and tumor growth in breast cancer cells.
|
30482236 |
2018 |