×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
CausalMutation
CLINVAR
Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease.
24556621 2014
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
GeneticVariation
CLINVAR
Contribution of germline mutations in cancer predisposition genes to tumor etiology in young women diagnosed with invasive breast cancer.
28503720 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
CausalMutation
CLINVAR
Evaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer.
27153395 2016
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
GeneticVariation
CLINVAR
Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients.
24763289 2014
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
CausalMutation
CLINVAR
Rare, evolutionarily unlikely missense substitutions in CHEK2 contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening study.
21244692 2011
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
GeneticVariation
CLINVAR
Pancreatic cancer as a sentinel for hereditary cancer predisposition.
29945567 2018
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
GeneticVariation
CLINVAR
A risk of breast cancer in women - carriers of constitutional CHEK2 gene mutations, originating from the North - Central Poland.
24713400 2014
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
GeneticVariation
CLINVAR
BRCA1, TP53, and CHEK2 germline mutations in uterine serous carcinoma.
22811390 2013
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
CausalMutation
CLINVAR
CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer.
18725978 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
GeneticVariation
CLINVAR
Revisiting breast cancer patients who previously tested negative for BRCA mutations using a 12-gene panel.
27798748 2017
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
GeneticVariation
CLINVAR
Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import.
12909615 2003
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
CausalMutation
CLINVAR
Next-generation sequencing for the diagnosis of hereditary breast and ovarian cancer using genomic capture targeting multiple candidate genes.
24549055 2014
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
GeneticVariation
CLINVAR
Association of two mutations in the CHEK2 gene with breast cancer.
15810020 2005
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
GeneticVariation
CLINVAR
Mutations in CHEK2 associated with prostate cancer risk.
12533788 2003
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
GeneticVariation
CLINVAR
Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer.
18571837 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
CausalMutation
CLINVAR
CHEK2 1100delC variant and breast cancer risk in Caucasians: a meta-analysis based on 25 studies with 29,154 cases and 37,064 controls.
22994785 2012
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
GeneticVariation
CLINVAR
Characterization of CHEK2 mutations in prostate cancer.
16835864 2006
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
CausalMutation
CLINVAR
Use of Whole Genome Sequencing for Diagnosis and Discovery in the Cancer Genetics Clinic.
26023681 2015
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
GeneticVariation
CLINVAR
Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population.
15649950 2005
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
GeneticVariation
CLINVAR
Breast cancer risk is similar for CHEK2 founder and non-founder mutation carriers.
27751358 2016
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
CausalMutation
CLINVAR
Predisposition gene identification in common cancers by exome sequencing: insights from familial breast cancer.
22527104 2012
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
CausalMutation
CLINVAR
Panel-based testing for inherited colorectal cancer: a descriptive study of clinical testing performed by a US laboratory.
24506336 2014
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
CausalMutation
CLINVAR
A risk of breast cancer in women - carriers of constitutional CHEK2 gene mutations, originating from the North - Central Poland.
24713400 2014
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
GeneticVariation
CLINVAR
Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA.
26556299 2016
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Malignant neoplasm of breast
0.800
GeneticVariation
CLINVAR
Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis.
12855706 2003