×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
PI3K /AKT pathway may represent an important therapeutic target for gastric cancer .23058013 2012
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
PI3K /AKT/β-Catenin Signaling Regulates Vestigial-Like 1 Which Predicts Poor Prognosis and Enhances Malignant Phenotype in Gastric Cancer .31816819 2019
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
GeneticVariation
BEFREE
A case-control study of 1275 GC patients and 1436 controls was performed to explore the associations of potentially functional SNPs in PI3K /Akt/mTOR pathway genes with the risk of GC .
29802999 2018
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
A specific phosphoinositide 3-kinase (PI3K ) inhibitor, wortmannin, was used to test the effect of PI3K inhibition on the secretion of CCL-2 in gastric cancer .
29422964 2018
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
AlteredExpression
BEFREE
Activation of PI3K /Akt pathway may be a key regulatory mechanism of ADAMTS9-AS2 in gastric cancer .
30089248 2018
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
AdP promoted apoptosis in CDDP-resistant GC cells by suppressing the PI3K /AKT/ARNT signaling pathway and might be considered a candidate agent for the clinical treatment of cisplatin-resistant GC .
29522284 2018
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
AIB1 induces epithelial-mesenchymal transition in gastric cancer via the PI3K /AKT signaling.
31692102 2019
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
All the data showed that high expression of ABL2 suppresses apoptosis through Ras/Erk and PI3K /AKT signaling pathway in GC cell lines.
29767389 2018
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
AlteredExpression
BEFREE
Analysis of correlation between HP infection and activation of PI3K /Akt pathway in mucosal tissues of gastric cancer and precancerous lesions.
30344716 2018
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
AURKA induces EMT by regulating histone modification through Wnt/β-catenin and PI3K /Akt signaling pathway in gastric cancer .
27121204 2016
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
Celecoxib sensitizes gastric cancer to rapamycin via inhibition of the Cbl-b-regulated PI3K /Akt pathway.
25701378 2015
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
AlteredExpression
BEFREE
Clinical value of CagA, c-Met, PI3K and Beclin-1 expressed in gastric cancer and their association with prognosis.
29422968 2018
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
Collectively, the PI3K /Akt signaling pathway may be an effective therapeutic target in gastric cancer .
22292935 2012
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
Cooperative relationships were identified between PI3K and Akt, and PI3K and survivin (P<0.01), suggesting the involvement of the PI3K /Akt/survivin signaling pathway in the tumorigenesis of gastric cancer .
24726064 2014
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
CXCL10/CXCR3 axis promotes the invasion of gastric cancer via PI3K /AKT pathway-dependent MMPs production.
27470388 2016
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
Dual PI3K /mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway.
29374144 2018
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
Dual inhibitor of PI3K and mTOR (NVP-BEZ235) augments the efficacy of fluorouracil on gastric cancer chemotherapy.
30275715 2018
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
AlteredExpression
BEFREE
Dysregulated lncRNA-UCA1 contributes to the progression of gastric cancer through regulation of the PI3K -Akt-mTOR signaling pathway.
29212166 2017
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
F-box protein 11 promotes the growth and metastasis of gastric cancer via PI3K /AKT pathway-mediated EMT.
29278851 2018
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
AlteredExpression
BEFREE
Finally, we suggested the involvement of the PI3K /AKT pathway in CUL4B-induced HER2 upregulation in GC .
29106389 2018
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
Furthermore, knockdown of UBE2C using siRNA markedly reduced the level of phosphorylation AURKA (p‑AURKA) via Wnt/β‑catenin and PI3K /Akt signaling pathways suppressed the occurrence and development of gastric cancer .
28260026 2017
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
Furthermore, overexpression of ciRS-7 blocked the miR-7-induced tumor suppression in MGC-803 and HGC-27 cells and led to a more aggressive oncogenic phenotype, via antagonizing miR-7-mediated PTEN/PI3K /AKT pathway. ciRS-7 may act as a prospective prognostic biological marker and a promising therapeutic target for GC ..
28608528 2018
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
Hence, it is necessary to clarify not only HER2 alterations but also PI3K -Akt pathway alterations for HER2-targeting therapy in GC .
24458107 2014
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
AlteredExpression
BEFREE
Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K /Akt/NF-κB signaling pathway for gastric cancer metastasis.
25727320 2015
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Malignant neoplasm of stomach
0.100
Biomarker
BEFREE
Herein, we review the common dysregulation of PI3K /Akt/mTOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment.
26604635 2015