Entrez Id: |
5290 |
Gene Symbol: |
PIK3CA |
PIK3CA
|
Mammary Neoplasms
|
0.500 |
GeneticVariation |
CLINVAR |
We identified PIK3CA mutations in 26% of 342 human breast tumor samples and cell lines at about equal frequency in tumor stages I to IV.
|
15805248 |
2005 |
Entrez Id: |
11200 |
Gene Symbol: |
CHEK2 |
CHEK2
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population.
|
15649950 |
2005 |
Entrez Id: |
7157 |
Gene Symbol: |
TP53 |
TP53
|
Mammary Neoplasms
|
0.700 |
GeneticVariation |
CLINVAR |
The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.
|
16489069 |
2006 |
Entrez Id: |
11200 |
Gene Symbol: |
CHEK2 |
CHEK2
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer.
|
16551709 |
2006 |
Entrez Id: |
2064 |
Gene Symbol: |
ERBB2 |
ERBB2
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.
|
16397024 |
2006 |
Entrez Id: |
11200 |
Gene Symbol: |
CHEK2 |
CHEK2
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Breast tumors which arise in carriers of CHEK2 mutations seem to be similar to those of breast cancers in the population at large.
|
16914568 |
2006 |
Entrez Id: |
8924 |
Gene Symbol: |
HERC2 |
HERC2
|
Mammary Neoplasms
|
0.100 |
CausalMutation |
CLINVAR |
Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.
|
16397024 |
2006 |
Entrez Id: |
11200 |
Gene Symbol: |
CHEK2 |
CHEK2
|
Mammary Neoplasms
|
0.500 |
GeneticVariation |
CLINVAR |
Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts.
|
17721994 |
2007 |
Entrez Id: |
11200 |
Gene Symbol: |
CHEK2 |
CHEK2
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Germline CHEK2 mutations in Jewish Ashkenazi women at high risk for breast cancer.
|
18085035 |
2007 |
Entrez Id: |
11200 |
Gene Symbol: |
CHEK2 |
CHEK2
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer.
|
18571837 |
2008 |
Entrez Id: |
5290 |
Gene Symbol: |
PIK3CA |
PIK3CA
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.
|
18725974 |
2008 |
Entrez Id: |
5290 |
Gene Symbol: |
PIK3CA |
PIK3CA
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
|
18676830 |
2008 |
Entrez Id: |
2064 |
Gene Symbol: |
ERBB2 |
ERBB2
|
Mammary Neoplasms
|
0.500 |
GeneticVariation |
CLINVAR |
EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation.
|
18413839 |
2008 |
Entrez Id: |
672 |
Gene Symbol: |
BRCA1 |
BRCA1
|
Mammary Neoplasms
|
0.500 |
GeneticVariation |
CLINVAR |
Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays.
|
20516115 |
2010 |
Entrez Id: |
5728 |
Gene Symbol: |
PTEN |
PTEN
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.
|
20453058 |
2010 |
Entrez Id: |
5290 |
Gene Symbol: |
PIK3CA |
PIK3CA
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.
|
20453058 |
2010 |
Entrez Id: |
5728 |
Gene Symbol: |
PTEN |
PTEN
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
The PI3K pathway as drug target in human cancer.
|
20085938 |
2010 |
Entrez Id: |
2264 |
Gene Symbol: |
FGFR4 |
FGFR4
|
Mammary Neoplasms
|
0.140 |
GeneticVariation |
CLINVAR |
The FGFR4 Y367C mutant is a dominant oncogene in MDA-MB453 breast cancer cells.
|
19946327 |
2010 |
Entrez Id: |
6093 |
Gene Symbol: |
ROCK1 |
ROCK1
|
Mammary Neoplasms
|
0.120 |
GeneticVariation |
CLINVAR |
Activating ROCK1 somatic mutations in human cancer.
|
20140017 |
2010 |
Entrez Id: |
2064 |
Gene Symbol: |
ERBB2 |
ERBB2
|
Mammary Neoplasms
|
0.500 |
GeneticVariation |
CLINVAR |
Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib.
|
22046346 |
2011 |
Entrez Id: |
5290 |
Gene Symbol: |
PIK3CA |
PIK3CA
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations.
|
21558396 |
2011 |
Entrez Id: |
11200 |
Gene Symbol: |
CHEK2 |
CHEK2
|
Mammary Neoplasms
|
0.500 |
GeneticVariation |
CLINVAR |
CHEK2 contribution to hereditary breast cancer in non-BRCA families.
|
22114986 |
2011 |
Entrez Id: |
672 |
Gene Symbol: |
BRCA1 |
BRCA1
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Characteristics and spectrum of BRCA1 and BRCA2 mutations in 3,922 Korean patients with breast and ovarian cancer.
|
22798144 |
2012 |
Entrez Id: |
5290 |
Gene Symbol: |
PIK3CA |
PIK3CA
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.
|
22162589 |
2012 |
Entrez Id: |
672 |
Gene Symbol: |
BRCA1 |
BRCA1
|
Mammary Neoplasms
|
0.500 |
CausalMutation |
CLINVAR |
Functional differences among BRCA1 missense mutations in the control of centrosome duplication.
|
21725363 |
2012 |