×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
GeneticVariation
BEFREE
No evidence for germline mutations in exons 5-9 of the p53 gene in 25 breast cancer families.
1570151 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
Biomarker
BEFREE
We have investigated the expression of ras p21, Rb1 and p53 proteins in human breast cancer patients immunohistochemically, and correlated the results with a range of clinical and pathological parameters.
1567185 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
GeneticVariation
BEFREE
Moreover, somatically acquired p53 mutations and gene deletions are common feature in breast cancer of sporadic origin.
1587536 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
GeneticVariation
BEFREE
Germ-line mutations in the p53 tumor suppressor gene have been observed in patients with Li-Fraumeni syndrome, brain tumors, second malignancies, and breast cancers .
1631137 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
AlteredExpression
BEFREE
Retinoblastoma and p53 gene expression related to relapse and survival in human breast cancer : an immunohistochemical study.
1453267 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
GeneticVariation
BEFREE
Screening for germ line TP53 mutations in breast cancer patients.
1591732 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
AlteredExpression
BEFREE
In this study, we evaluated the prognostic significance of p53 protein overexpression in patients with ANN breast cancer .
1352359 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
AlteredExpression
BEFREE
We examined 100 breast cancers for retinoblastoma (Rb) and p53 protein expression by immunohistochemistry using the PMG3.245 and PAb 1801 antibodies.
1468776 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
GeneticVariation
BEFREE
We examined 126 consecutive patients who developed breast cancer at or before the age of 40 for mutations of p53 within conserved regions of the gene.
1581912 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
AlteredExpression
BEFREE
Using this reagent we have found that aberrant expression of p53 is a frequent feature of human breast cancer .
1569122 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
Biomarker
BEFREE
Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers .
1373500 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
GeneticVariation
BEFREE
The p53 locus on the short arm of chromosome 17 at 17p 13.1 was examined for loss of heterozygosity, mutation, mRNA and protein expression in 60 primary breast cancers .
1537617 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
Biomarker
BEFREE
This study was designed to determine whether p53 protein accumulation in breast cancers correlates with p53 gene mutation, with survival, and with five pathobiologic factors associated with prognosis.
1317462 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
Biomarker
BEFREE
These data suggest that some breast cancers that contain the wild-type form of p53 protein may inactivate its tumor-suppressing activity by sequestering this protein in the cytoplasm, away from its site of action in the cell nucleus.
1353891 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
AlteredExpression
BEFREE
Regulation of p53 protein expression in human breast cancer cell lines.
8408290 1993
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
GeneticVariation
BEFREE
The ability of RB and p53 genes to suppress the tumorigenicity of breast carcinoma cells provides functional evidence that deletion or mutational inactivation of tumor suppressor genes represents an important step in the genesis of breast cancer .
8426737 1993
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
GeneticVariation
BEFREE
William L. McGuire Memorial Symposium. The role and prognostic significance of p53 gene alterations in breast cancer .
8260732 1993
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
AlteredExpression
BEFREE
Other potential prognostic markers in breast cancer include amplification of the c-myc gene, and increased expression of both EGFR and p53 protein.
8124858 1993
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
AlteredExpression
BEFREE
c-erbB-2 oncogene related to p53 expression, cell proliferation and prognosis in breast cancer .
8102517 1993
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
GeneticVariation
BEFREE
Our results indicate that accumulation of p53 protein, as detectable by IHC, is not a reliable indicator for p53 gene mutation in human breast cancer .
8287224 1993
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
GeneticVariation
BEFREE
This would argue for an important role of heterozygous p53 mutations in human breast cancer .
8444469 1993
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
GeneticVariation
BEFREE
Absence of germline mutations of exons 5 to 8 of the P53 gene in 26 breast cancer families from the north of France.
8398277 1993
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
GeneticVariation
BEFREE
These p53 mutation patterns in breast cancer in Japan are not similar to those in Europe and America reported by Hollstein et al. and Coles et al..
8312582 1993
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
Biomarker
BEFREE
We compiled a mutational spectrum of p53 from 120 breast cancers and compared it with the spectrum from 145 colorectal cancers and 246 lung cancers.
8377645 1993
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Malignant neoplasm of breast
1.000
AlteredExpression
BEFREE
Immunohistochemically detected p53 overexpression is an independent marker for shortened 6-year relapse-free and overall survival in node-negative patients with resectable breast cancers .
8496982 1993