Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.050 GeneticVariation BEFREE Interleukin-12B heterozygosity is associated with Behçet's disease susceptibility and plays an important role in mediating T helper type 1 antistreptococcal immune response. 18281862

2008
Entrez Id: 115650
Gene Symbol: TNFRSF13C
TNFRSF13C
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.010 AlteredExpression BEFREE BAFF-R expression on B cells was increased in BD patients with vasculitis. 19026118

2009
Entrez Id: 3812
Gene Symbol: KIR3DL2
KIR3DL2
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.040 GeneticVariation BEFREE Killer cell immunoglobulin-like receptor genotypes in Behçet's disease patients: any role for the 3DP1*001/002 pseudogene? 19405872

2009
Entrez Id: 3806
Gene Symbol: KIR2DS1
KIR2DS1
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.030 GeneticVariation BEFREE Killer cell immunoglobulin-like receptor genotypes in Behçet's disease patients: any role for the 3DP1*001/002 pseudogene? 19405872

2009
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.100 GeneticVariation BEFREE eNOS gene polymorphisms associated with BD are not associated with RAS. 19410237

2009
Entrez Id: 4792
Gene Symbol: NFKBIA
NFKBIA
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.020 GeneticVariation BEFREE IkappaBalpha promoter polymorphisms in patients with Behçet's disease. 20164548

2010
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.080 Biomarker BEFREE IL-23 has been shown to be involved in the pathogenesis of Behcet's disease (BD) through promoting IL-17 production. 20375120

2010
Entrez Id: 3105
Gene Symbol: HLA-A
HLA-A
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.100 Biomarker BEFREE HLA-A*02:07, A*26:01, and A*30:04 were associated with increased risk for BD, while HLA-A*33:03 with decreased risk. 21429233

2011
Entrez Id: 4210
Gene Symbol: MEFV
MEFV
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.500 Biomarker BEFREE MEFV gene analysis was performed in all the patients with BD and healthy controls; twelve different regions were scanned. 21901355

2012
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.020 Biomarker BEFREE IFN-α had been used clinically in treating BD with uveitis with beneficial efficacy ever since the 1980s. 22197901

2012
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.020 Biomarker BEFREE IFN-α had been used clinically in treating BD with uveitis with beneficial efficacy ever since the 1980s. 22197901

2012
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.090 GeneticVariation BEFREE TNFAIP3 gene polymorphisms confer risk for Behcet's disease in a Chinese Han population. 23161053

2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.100 Biomarker BEFREE IL-1β and ROS production of peptidoglycan (PGN)/lipopolysaccharide (LPS)-induced MDMs from active BD patients was significantly increased compared with inactive BD patients, AAU patients, and healthy controls. 23211828

2013
Entrez Id: 79001
Gene Symbol: VKORC1
VKORC1
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.010 GeneticVariation BEFREE VKORC1 polymorphisms seem not to be related with the thrombotic state of systemic and ocular Behçet's disease. 23362849

2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.010 Biomarker BEFREE SIRT1 activator treatment in vitro using mouse pLN cells, normal human and ocular Behçet's disease donor PBMC resulted in suppressed T cell proliferation and pro-inflammatory cytokine production. 23395551

2013
Entrez Id: 2069
Gene Symbol: EREG
EREG
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.010 GeneticVariation BEFREE EREG-AREG and NRG1, which are members of the epidermal growth factor (EGF) family, seem to modulate BD susceptibility through main effects and gene-gene interactions. 23625463

2013
Entrez Id: 114609
Gene Symbol: TIRAP
TIRAP
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.020 GeneticVariation BEFREE TIRAP S180L gene polymorphism, which was previously shown to be associated with BD in a Caucasian population, has been replicated in either Turkish or Italian population in our study. 24064014

2013
Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 Biomarker BEFREE IL10 may be the susceptibility gene for BD in Chinese Han population. 24269690

2014
Entrez Id: 3105
Gene Symbol: HLA-A
HLA-A
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.100 Biomarker BEFREE HLA-A*26 was claimed as an additional BD susceptibility marker in Japanese and Greek patients. 24887019

2014
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.060 GeneticVariation BEFREE IL-18 gene polymorphisms were not associated with any susceptibility to aphthous stomatitis, while a positive association was found with patients with Behçet's disease regarding -607 promoter site. 24935632

2014
Entrez Id: 2109
Gene Symbol: ETFB
ETFB
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.010 Biomarker BEFREE Electron Transfer Flavoprotein Subunit Beta Is a Candidate Endothelial Cell Autoantigen in Behçet's Disease. 25915519

2015
Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation BEFREE Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population. 26015771

2015
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 Biomarker BEFREE HLA-B*15, -B*27, -B*57, and -A*26 are independent risk factors for Behçet's disease, while HLA-B*49 and -A*03 are independent class I alleles that are protective for Behçet's disease. 26347074

2015
Entrez Id: 3135
Gene Symbol: HLA-G
HLA-G
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.030 GeneticVariation BEFREE HLA-G 14 bp insertion/deletion polymorphism and its association with sHLA-G levels in Behçet's disease Tunisian patients. 26519864

2016
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.020 GeneticVariation BEFREE NOS2/ rs4795067 and NOS3/rs1800779 were not associated with either BD or VKH syndrome. 27114698

2016