Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE We developed dual IHC staining for p27 and pY88, and found that benign breast epithelium was negative, while breast cancer biopsies (of varied hormonal status) could be stratified for pY88 status. 30559257

2019

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker BEFREE Our data support a role for p27 in regulating the pool size of hormone-responsive luminal progenitors that could impact breast cancer risk. 30893315

2019

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression BEFREE Moreover, we found that siRNA-LINC00899 could elevate RBL2, p21, p27 and Bax levels, decrease FoxO, Bcl-2, Vimentin, Annexin levels, reduced cell proliferation, migration and invasion and enhanced apoptosis. 31432742

2019

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker BEFREE Our results show that T198 phosphorylation of p27 controls the interaction between p27 and STMN1 that regulates microtubule stabilization and the invasion and migration of osteosarcoma cells. 30992462

2019

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression BEFREE MiR-221 plays a role in promoting tumorigenesis in HCC by inhibiting the expression of p27. 31839741

2019

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
Malignant neoplasm of colon and/or rectum
0.100 Biomarker BEFREE The prognostic role of Skp2 and the tumor suppressor protein p27 in colorectal cancer. 29135092

2019

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 Biomarker BEFREE PSMD2 regulates breast cancer cell proliferation and cell cycle progression by modulating p21 and p27 proteasomal degradation. 29777785

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 Biomarker BEFREE The use of ALT demonstrates that both CDK4 and CDK2 need to be inhibited if long-term efficacy is to be achieved and represents a novel modality to inhibit breast cancer cells.<b>Implications:</b> Modulating tyrosine phosphorylation of p27 impacts both proliferative (CDK4) and resistance (CDK2) mechanisms in breast cancer and suggests that phospho-p27 status may serve as a biomarker for patients that are responsive to CDK4/6 inhibition.<i></i>. 29330290

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 Biomarker BEFREE The objective of our study was to determine the association between expression of c-Myc and the loss of p27 by immunohistochemistry (IHC) in the four major subtypes of breast cancer (BC) (Luminal A, Luminal B, HER2, and Triple Negative) and with other clinicopathological factors in a population of 202 African-American (AA) women. 29715580

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 Biomarker BEFREE Molecular mechanisms underlying progesterone-induced cytoplasmic retention of p27 in breast cancer cells. 29959971

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 AlteredExpression BEFREE TOP2A, Ki67, and cyclin D1, as categorical variables were not predictive, whereas cyclin D1 as continuous variable was predictive of trastuzumab benefit.<b>Conclusions:</b> In TransHERA, patients with HER2-positive early breast cancer with low p27 expression in their tumors benefited from trastuzumab treatment, whereas patients with high p27 expression did not.<i></i>. 29530933

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 AlteredExpression BEFREE In luminal breast cancers, E+MPA HRT (n = 6) was also associated with decreased nuclear expression of the cell cycle inhibitor p27 compared to E HRT (n = 6), but was not associated with increased proliferation. 29524829

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 AlteredExpression BEFREE Expressions of miR-222 and p27 were significantly inversely correlated, and cytoplasmic p27, instead of nuclear p27, was associated with tumor malignancy. miR-222 could be transmitted between PDAC cells via exosome communication, and the exosomal miR-222 communication is functional. 30458449

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 AlteredExpression BEFREE TOP2A, Ki67, and cyclin D1, as categorical variables were not predictive, whereas cyclin D1 as continuous variable was predictive of trastuzumab benefit.<b>Conclusions:</b> In TransHERA, patients with HER2-positive early breast cancer with low p27 expression in their tumors benefited from trastuzumab treatment, whereas patients with high p27 expression did not.<i>Clin Cancer Res; 24(13); 3079-86.©2018 AACR</i>. 29530933

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 GeneticVariation BEFREE Additionally, 60 DTCs-related microarray and RNA-seq datasets were obtained to investigate the expression level and clinical value of p27 gene in DTCs patients. 29552310

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Altogether, p27 haploinsufficiency in MENX rats uncovered a novel, representative model of invasive and metastatic MTC exploitable for translational studies of this often aggressive and incurable cancer. 29142006

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Here we show that two p53-responsive miRNAs utilize distinct but complementary mechanisms to promote cancer cell quiescence by facilitating stabilization of p27. 30301840

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Moreover, we found some gene functions, such as Fused in Sarcoma (FUS, which may be part of transcriptional misregulation in cancer) and p27 (which we expect will become a member viral carcinogenesis), that can be used to complete the related pathways. 29321535

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 AlteredExpression BEFREE Further studies revealed that the compounds were able to induce cancer cell differentiation and concomitantly downregulate cyclin D1 expression with upregulation of p27 levels, consistent with cell cycle arrest at the G1 phase. 30374056

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.100 Biomarker BEFREE Polygodial, P3, and P27 all significantly decreased OSCC tumor growth, with P27 being equipotent with polygodial and P3 being the least efficacious. 30320372

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE We also found that miR-1290 overexpression reduced the p27 level and increased cyclin D1 at both the mRNA and protein levels, whereas miR-1290 knockdown increased p27 and reduced cyclin D1, confirming miR-1290 promoted CRC cell proliferation. 28915933

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE The reduction of either p21 or p27 levels by shRNA can decrease NDRG2-induced AKP activity and resume cell growth inhibition, thus both p21 and p27 are required for NDRG2 effect on the promotion of cell differentiation in CRCs. 29343851

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE The combined ORs indicated that a low expression of p27 protein was positively related to lymph node metastasis (OR: 2.15, 95% CI: 1.57-2.96, <i>P</i> < 0.0001), distant metastasis (OR: 2.02, 95% CI: 1.12-3.63, <i>P =</i> 0.019) and pathology grading (OR: 2.14, 95% CI: 1.75-2.62, <i>P</i> < 0.0001). 29552310

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.100 AlteredExpression BEFREE miR-222 is significantly high in tumor exosomes or highly invasive PDAC cells. miR-222 could directly regulate p27 to promote cell invasion and proliferation. miR-222 could also activate AKT by inhibiting PPP2R2A expression, thus inducing p27 phosphorylation and cytoplasmic p27 expression to promote cell survival, invasion and metastasis. 30458449

2018

Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE In PRL, the deficiency in p21 and p27 contributed to the tumor proliferation and migration and Cdk inhibitors may be used as a new therapeutic approach. 29230669

2018