Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Extensive research has elucidated the pivotal role of OPN in cell signaling that controls inflammation, tumor progression, and metastasis. 17890765

2008

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 GeneticVariation BEFREE The biological functions and representative deregulated genes include cell proliferation (AIM2, FAP, TNFSF13B, TMPRSS11A); signal transduction (FOLR2, MME, HTR3B); invasion and metastasis (SPP1, TNFAIP6, EPHB6); differentiation (CLEC4A, ELF5); angiogenesis (CXCL1); apoptosis (GLIPR1, WISP1, DAPL1); and immune responses (CD300A, IFIT2, TREM2); and metabolism (NNMT; ALDH3A1). 25663065

2015

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Studies have demonstrated that small integrin‑binding ligand N‑linked glycoproteins (SIBLINGs), particularly bone sialoprotein (BSP) and osteopontin (OPN), are involved in neoplastic growth and metastasis. 29917166

2018

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Given these opposing traits of extracellular Hsp70 and the unsatisfactory outcome of locally advanced lung tumors, we investigated the role of Hsp70 in the plasma of patients with advanced, non-metastasized non-small-cell lung cancer (NSCLC) before (T1) and 4-6 weeks after RT (T2) in relation to OPN as potential biomarkers for clinical response. 29093708

2017

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE The role of osteopontin in tumor progression and metastasis in breast cancer. 17548669

2007

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Osteopontin (OPN) is involved in cancer development and metastasis. 29607144

2018

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Here we report that TIP30 suppresses metastasis of hepatocellular carcinoma (HCC) through inhibiting the transcription of osteopontin (OPN), a key molecule in the development of tumor metastasis. 18537194

2008

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE We conclude that tumor-derived OPN engenders MSC-to-CAF transformation in the microenvironment to promote tumor growth and metastasis via the OPN-MZF1-TGF-β1 pathway. 25531323

2015

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Osteopontin (OPN) or secreted phosphoprotein 1 (SPP1) is a matricellular glycoprotein whose expression is elevated in various types of cancer and has been shown to be involved in tumourigenesis and metastasis in many malignancies, including follicular cell-derived thyroid carcinomas. 26811408

2016

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Osteopontin (OPN), a secreted integrin-binding glycophosphoprotein, is associated with progression and metastasis in a variety of cancers and has been studied as a prognostic marker. 21795853

2011

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Osteopontin, a secreted glycoprotein, plays a role in cell survival, immunity, and tumor progression, its expression being associated with a poor prognosis and metastasis in several malignancies. 25824779

2015

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Bone sialoprotein (BSP) and osteopontin (OPN) are important factors in the metastasis of breast cancer, which were examined as targets for antineoplastic therapy by siRNA. 22407340

2012

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Several potential targets in the pathway can be manipulated to block the synthesis of osteopontin and inhibit liver cancer metastasis. 14716823

2004

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Furthermore, our results suggest that the JAG1/Notch1/OPN cascade represents a potential therapeutic target for hepatocellular carcinoma metastasis. 25176314

2014

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Indeed, osteopontin is a cardinal mediator of tumor-associated inflammation and facilitates metastasis. 31382483

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE The extracellular matrix (ECM) molecule osteopontin is implicated in many pathologic processes, including inflammation, cell proliferation, ECM invasion, tumor progression, and metastasis. 16000556

2005

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 GeneticVariation BEFREE This study provides the first evidence that variation at nt -443 in the OPN promoter increases the potential for gastric cancer metastasis and subsequent death in the Chinese population. 23072570

2012

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Role of the metastasis-promoting protein osteopontin in the tumour microenvironment. 20597997

2010

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE OPN and hs-CRP correlate with each other, with neutrophil count and biochemical markers of metastatic disease. 31376097

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE The expression of osteopontin (OPN), a gene regulating every step in tumor progression and metastasis, was robustly up-regulated by LSF. 20404171

2010

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE This study suggests that breast cancer cells that have metastasized to bone may have a survival advantage resulting from interaction of alphavbeta3 on these cells with the bone protein osteopontin. 11078811

2000

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE In addition, several reports have revealed that osteopontin (OPN) plays important roles in tumor cell migration. 22355367

2012

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE OPN-c is more potent than OPN-a in supporting anchorage-independence and may be critical for metastasis. 23359517

2014

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker BEFREE Osteopontin (OPN) is an important chemokine involved in the survival, proliferation, migration, invasion and metastasis of gastric cancer cells. 21406114

2011

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression BEFREE Thus, we investigated the transcriptional activation of the OPN promoter in the human metastatic cancer cell line A2058. 14712233

2004