×
Entrez Id: 7490
Gene Symbol: WT1
WT1
Leukemia, Myelocytic, Acute
0.700
GeneticVariation
CLINVAR
Clinical impact of gene mutations and lesions detected by SNP-array karyotyping in acute myeloid leukemia patients in the context of gemtuzumab ozogamicin treatment: results of the ALFA-0701 trial.
24659740 2014
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Leukemia, Myelocytic, Acute
0.700
GeneticVariation
CLINVAR
Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients.
24487413 2014
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Continuing aspirin in the perioperative patient.
22504186 2012
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia.
24046014 2013
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia.
22504183 2012
×
Entrez Id: 3815
Gene Symbol: KIT
KIT
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Dasatinib inhibits proliferation and induces apoptosis in the KASUMI-1 cell line bearing the t(8;21)(q22;q22) and the N822K c-kit mutation.
23149070 2013
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
De novo childhood myelodysplastic/myeloproliferative disease with unique molecular characteristics.
22571758 2012
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3.
15667533 2005
×
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
DNMT3A mutations in acute myeloid leukemia.
21067377 2010
×
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
Leukemia, Myelocytic, Acute
0.700
CausalMutation
CLINVAR
Evaluation of mutations in the isocitrate dehydrogenase genes in therapy-related and secondary acute myeloid leukaemia identifies a patient with clonal evolution to IDH2 R172K homozygosity due to uniparental disomy.
21250968 2011
×
Entrez Id: 2624
Gene Symbol: GATA2
GATA2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency.
21765025 2011
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.
23878140 2013
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression.
15374878 2005
×
Entrez Id: 7010
Gene Symbol: TEK
TEK
Leukemia, Myelocytic, Acute
0.140
GeneticVariation
CLINVAR
Functional characterization of an activating TEK mutation in acute myeloid leukemia: a cellular context-dependent activating mutation.
19340004 2009
×
Entrez Id: 23451
Gene Symbol: SF3B1
SF3B1
Leukemia, Myelocytic, Acute
0.500
GeneticVariation
CLINVAR
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.
23634996 2013
×
Entrez Id: 1441
Gene Symbol: CSF3R
CSF3R
Leukemia, Myelocytic, Acute
0.500
GeneticVariation
CLINVAR
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.
23634996 2013
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Leukemia, Myelocytic, Acute
0.700
CausalMutation
CLINVAR
Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.
20949621 2011
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Leukemia, Myelocytic, Acute
0.700
CausalMutation
CLINVAR
Germline KRAS mutations cause Noonan syndrome.
16474405 2006
×
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.
10508512 1999
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Leukemia, Myelocytic, Acute
0.700
GeneticVariation
CLINVAR
Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice.
24381225 2014
×
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
High frequency of RUNX1 biallelic alteration in acute myeloid leukemia secondary to familial platelet disorder.
19357396 2009
×
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
Leukemia, Myelocytic, Acute
0.700
GeneticVariation
CLINVAR
High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients.
19075190 2009
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Leukemia, Myelocytic, Acute
0.700
GeneticVariation
CLINVAR
High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients.
19075190 2009
×
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016