×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Cetuximab treatment for metastatic colorectal cancer with KRAS p.G13D mutations improves progression-free survival.
26623049 2015
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal antibody therapy for RAS wild-type metastatic colorectal cancer.
25989278 2015
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Colorectal Neoplasms
0.500
GeneticVariation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968 2014
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.
24163374 2014
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
KRAS G13D Mutation and Sensitivity to Cetuximab or Panitumumab in a Colorectal Cancer Cell Line Model.
24558511 2014
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAFV600E mutation and its association with clinicopathological features of colorectal cancer: a systematic review and meta-analysis.
24594804 2014
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968 2014
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968 2014
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Vemurafenib synergizes with nutlin-3 to deplete survivin and suppresses melanoma viability and tumor growth.
23812671 2013
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.
23845441 2013
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase III study of metastatic colorectal cancer.
23325582 2013
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase III study of metastatic colorectal cancer.
23325582 2013
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAF V600E is a determinant of sensitivity to proteasome inhibitors.
24107445 2013
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer: assessment as prognostic and predictive biomarkers of response to panitumumab.
23182985 2013
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.
23549875 2013
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.
23251002 2013
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma.
22535154 2012
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas.
22392911 2012
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.
22281684 2012
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer.
22722830 2012
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer.
22180495 2012
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab.
22734028 2012
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
The road to resistance: EGFR mutation and cetuximab.
22310681 2012
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Colorectal Neoplasms
0.500
GeneticVariation
CLINVAR
Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer.
22270724 2012
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.
22608338 2012