Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 AlteredExpression BEFREE This mode of action for calycopterin in our study provides strong support that inhibition of PI3K/Akt and activation of MAPKs are pivotal in G2/M cell cycle arrest and apoptosis of human hepatocarcinoma cells mediated by calycopterin. 25060910

2014

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE These results are consistent with the possibility that YSV mediates inhibition of tumor growth through inhibition of the PI3K pathway and suggests that YSV should be explored for use as an antitumor agent for hepatocarcinoma. 16184552

2006

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 AlteredExpression BEFREE These findings strongly suggest that HSP20 directly associates with PI3K and suppresses its activity in HCC, resulting in the inhibition of the AKT pathway, and subsequently decreasing the growth of HCC. 24223153

2013

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE These findings reveal that Tmod3 enhances aggressive behavior of HCC both in vitro and in vivo by interacting with EFGR and by activating the PI3K-AKT signaling pathway. 31313392

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE These findings indicate that miR-7 functions as a tumor suppressor and plays a substantial role in inhibiting the tumorigenesis and reversing the metastasis of HCC through the PI3K/Akt/mTOR-signaling pathway in vitro and in vivo. 22234835

2012

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE These data together implied that KLT might reverse drug resistance in HCC by blocking the PI3K/AKT signaling. 29520149

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE These data suggest that ASIC1a/Ca<sup>2+</sup>/PI3K/AKT signaling represents a novel pathway that regulates drug resistance, thus offering a potential target for chemotherapy of HCC. 27918554

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE These data confirmed that the downregulation of MARCH1 could inhibit the progression of hepatocellular carcinoma and that the mechanism may be via PI3K/AKT/β-catenin inactivation as well as the downregulation of the antiapoptotic Mcl-1/Bcl-2. 30678274

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE Therefore, our results suggest that miR-105 functions as a potential tumor suppressor by inhibiting the PI3K/AKT signaling pathway and might represent a potential therapeutic target for HCC patients. 25280563

2014

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE There were 19 HCCs with PIK3CA amplification. 31126975

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 GeneticVariation BEFREE The tumor suppressor PTEN is a protein/phosphoinositide phosphatase regulating the PI3K/Akt signaling pathway and is mutated or deleted in a variety of human cancers, including hepatocellular carcinoma (HCC). 20460918

2010

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE The results demonstrate that SIRT1 promotes tumorigenesis of hepatocellular carcinoma (HCC) through the PTEN/PI3K/AKT signaling pathway. 22552445

2012

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE The purpose of this study was to determine the impact of sorafenib on PI3K/AKT/mTOR signaling pathway and to further define its mechanism for treating hepatocellular carcinoma (HCC). 25778319

2015

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 AlteredExpression BEFREE The prosurvival, anti-apoptotic effect of SULF2 in HCC is mediated through activation of the PI3K/Akt pathway. 21040406

2010

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE The present study summarizes the major findings about the regulatory role of miRNAs in the PI3K/AKT/mTOR pathway in the pathogenesis of HCC. 31663122

2020

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE The PIK3 CA gene encodes the p110α protein subunit and is one of the most efficient cancer genes in solid and hematological tumors including hepatocellular carcinoma (HCC). 31668943

2020

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE The oncogenic PI3K/Akt/mTOR pathway is frequently activated in hepatocellular carcinoma (HCC). 27863926

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 GeneticVariation BEFREE The mutations found in this study were all different and small numbers, therefore, we cannot conclude specific relationship between clinical characteristics of HCC and mutation of PIK3CA. 23709421

2013

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma. 29803224

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE The inhibition of <i>PTEN</i>  could reverse the anti-tumor action caused by the knockdown of <i>miR-367</i>  <i>MiR-367</i>  serves as an oncogene in HCC through activating the PI3K/AKT pathway by targeting <i>PTEN</i>. 31541003

2019

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 GeneticVariation BEFREE The frequency of the PIK3CA mutations in hepatocellular carcinoma seems to be lower in Chinese hepatocellular carcinoma patients. 21667306

2012

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE The following study aims to investigate the role of erinacine in the opening of the mitochondrial permeability transition pore (MPTP) in hepatocellular carcinoma (HCC) through the PI3K/Akt/GSK-3β signaling pathway and highlights the applicability of erinacine in HCC treatments. 30355923

2018

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE The effects of miRNA-133b in HCC are mediated through the EGFR/PI3K/Akt/mTOR signaling pathway. 28586051

2017

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 AlteredExpression BEFREE The correlation between increased PI3K/AKT/GSK-3β signaling with elevated Snail protein level was also observed in HCC tumor tissues with intrahepatic metastasis or chronic HBV infection. 22957763

2012

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker BEFREE Tanshinol exerts its anti-cancer effects via regulating the PI3K-AKT signaling pathway in HCC. 30588033

2019