Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE We performed integrative analysis for 3 sets of prostate cancer (PCa) genomic data, and found that BMI1 and androgen receptor (AR) were positively correlated, suggesting that AR might regulate BMI1. 31462713

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE Both hormone-sensitive and castration- and enzalutamide-resistant prostate cancers (PCa) depend on the ternary complex factor (TCF) protein ELK1 to serve as a tethering protein for the androgen receptor (AR) to activate a critical set of growth genes. 31794091

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE In this review, we will provide a comprehensive view of the effects of taxanes on androgen receptor signaling in prostate cancer. 29900882

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE Androgen receptor (AR) signaling plays a central role in metabolic reprogramming for prostate cancer (PCa) growth and progression. 31838085

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE Therefore, this review aims to summarize the tumor microenvironment and its impact on androgen receptor signaling in prostate cancer. 30528321

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE The major topic areas discussed at this year's meeting included (a) new insights into prostate cancer biology and treatment; (b) approaches for accelerating precision medicine for prostate cancer; (c) prostate-specific membrane antigen-targeted therapy and imaging for prostate cancer; (d) updates on Poly (ADP-ribose) polymerase (PARP)-inhibitor clinical trial results; (e) the biology and role of prostate cancer stem cells; (f) new approaches for targeting the androgen receptor and other steroid hormone receptor pathways; (g) racial disparities in prostate cancer treatment and outcomes; (h) the role of the nervous system in prostate cancer development and progression; (i) the role of the WNT signaling pathway in normal prostate and prostate cancer biology; (j) novel immunotherapy approaches; and (k) the ecology of prostate cancer. 31334865

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 AlteredExpression BEFREE ARD-69 is capable of reducing the AR protein level by >95% in these prostate cancer cell lines and effectively suppressing AR-regulated gene expression. 30629437

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 GeneticVariation BEFREE Despite the AR being one of the most studied and attended targets in cancer, those gain-of-function mutations in the receptor remain a significant challenge for the development of PCa therapies. 31698174

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE Androgen receptor (AR) signaling is a key pathway in prostate cancer, and patients are initially treated with androgen deprivation therapy. 30848157

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE The results of the present study suggested that miR-381 may act as a tumor suppressor in PCa by directly targeting the AR. 31423279

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE Inhibiting geranylgeranyl diphosphate synthesis reduces nuclear androgen receptor signaling and neuroendocrine differentiation in prostate cancer cell models. 30106164

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 AlteredExpression BEFREE Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer. 30334814

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE Darolutamide is a structurally unique androgen-receptor antagonist that is under development for the treatment of prostate cancer. 30763142

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE Prostate cancer (PCa) is driven by the androgen receptor (AR)-signaling axis. 30776192

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 GeneticVariation BEFREE Many genes exhibit evidence for allele-specific transcriptional activation by PrCa master-regulators (including androgen receptor) in Position Weight Matrix, Chip-Seq, and Hi-C experimental data, suggesting common regulatory mechanisms for the associated genes. 31308362

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE Suppressive Role of Androgen/Androgen Receptor Signaling via Chemokines on Prostate Cancer Cells. 30871130

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 AlteredExpression BEFREE To combat treatment resistance, down-regulating AR protein expression has been considered as a potential treatment strategy for CR-PCa. 30280407

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE Activation of PSGR with β-ionone suppresses prostate cancer progression by blocking androgen receptor nuclear translocation. 30928381

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE Collectively, this work provides a potential lead compound for anticancer agent development related to prostate cancer therapy, and took a step forward towards the development of novel and improved AR antagonists. 31493989

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE Current PC therapies prevalently target the functions of androgen receptor (AR) and may only be effective within short time periods, beyond which the majority of PC patients progress to castration-resistant PC (CRPC) and metastatic disease. 30828298

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 AlteredExpression BEFREE In agreement, bioinformatics analysis of clinical RNA sequencing data involving GSEA indicated a strong correlation between AR and EZH2 gene expression during PCa progression. 31085587

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE Since AR remains a driver of PCa in advanced disease, strategies targeting both lipid metabolism and AR are starting to emerge, providing new opportunities to re-sensitize tumors to endocrine therapies with lipid metabolic approaches. 31142021

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE AER-induced cytotoxicity on PCa cell lines seemed to be mediated by binding with AR. 30770950

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 GeneticVariation BEFREE The goal was to characterize androgen receptor gene (<i>AR</i>) amplifications and mutations detected in ctDNA from patients with PCa and to further understand the somatic genetic heterogeneity of advanced prostate cancer. 31712304

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker BEFREE Darolutamide (NUBEQA™) is a structurally distinct non-steroidal androgen receptor antagonist being developed by Orion and Bayer as a treatment for prostate cancer. 31605368

2019