Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.500 Biomarker BEFREE HLA-B*5703 seems to be a protective allele against the progression of HIV infection but could influence the increased incidence of SpA observed in this population. 15641063

2005

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.500 GeneticVariation BEFREE The factors determining differential HIV disease outcome among individuals expressing protective HLA alleles such as HLA-B*27:05 and HLA-B*57:01 remain unknown. 29338738

2018

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.500 GeneticVariation BEFREE They specifically demonstrate that the influence of ZNRD1 alleles on disease progression rates are attributable to HLA-A10, help clarify the relationship between the HCP5, HLA-C and HLA-B*57 alleles, and reaffirm a critical role of HLA-B*57 alleles in HIV disease. 18982067

2008

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.500 Biomarker BEFREE HIV subtype influences HLA-B*07:02-associated HIV disease outcome. 24010680

2014

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.500 GeneticVariation BEFREE CCR5delta32 in the context of untreated HIV disease, or HLA-B*5701 allele on the abacavir hypersensitivity reaction in the context of HAART), it is more likely that HIV disease and treatment outcomes are influenced by a multitude of interacting genotypes and phenotypes, a hypothesis that will become increasingly possible to investigate as improvements in molecular and computational technologies are made. 16848275

2006

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.500 Biomarker BEFREE Hence, aim of this study was to document association of HLA-B with HIV infection in DCs living in Mumbai, India. 24029662

2014

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.500 Biomarker BEFREE In two HIV C clade-infected populations in South Africa and Zambia, we sought to elucidate the role of HLA-B*5703 in HIV disease outcome. 19307327

2009

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.500 AlteredExpression BEFREE A similar scenario is observed in humans where the expression of HLA-B*27 or HLA-B*57 has been linked to slow or no progression to AIDS after HIV infection. 26811146

2016

Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 Biomarker BEFREE Increase of HIV-1 pro-viral DNA per million peripheral blood mononuclear cells in patients with advanced HIV disease (CD4<200 cells/mm3) receiving interleukin 2 combined with HAART versus HAART alone (ANRS-082 trial). 12924540

2003

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 AlteredExpression BEFREE The reduction in LPS-induced IL-12 p40 protein and mRNA following acute in vitro HIV infection of THP-1 cells and monocytes was not attributed to IL-10 or TGF-beta activity and was not restored by priming with IL-4, IL-13, or IFN-gamma. 12202149

2002

Entrez Id: 4153
Gene Symbol: MBL2
MBL2
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 GeneticVariation BEFREE In vitro studies have shown that MBL is able to bind to the gp120 HIV-1 surface antigen, and variants of the gene are associated with increased risk of HIV infection among Scandinavians. 12715245

2003

Entrez Id: 3811
Gene Symbol: KIR3DL1
KIR3DL1
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 Biomarker BEFREE The differential impact of natural killer (NK) cell education via KIR2DL3 and KIR3DL1 on CCL4 secretion in the context of in-vitro HIV infection. 27506421

2016

Entrez Id: 4153
Gene Symbol: MBL2
MBL2
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 Biomarker BEFREE We investigated the prevalence of variant alleles of MBL (detected by PCR) and assessed the prognostic value of these alleles and the corresponding serum MBL concentrations (measured by ELISA) in 96 homosexual men with HIV infection and in two control groups (123 healthy adults and 36 HIV-negative homosexual men at high risk of HIV infection because of their sexual behaviour).Follow-up was for up to 10 years. 9014910

1997

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 Biomarker BEFREE Twelve selected cytokines, including 9 inflammatory cytokines and chemokines (interleukin [IL]-1α, IL-1β, IL-6, tumor necrosis factor-α, IL-8, interferon-γ inducible protein-10 [IP-10], monocyte chemoattractant protein-1, macrophage inflammatory protein [MIP]-1α, MIP-1β), hematopoietic IL-7, and granulocyte macrophage colony-stimulating factor, and regulatory IL-10 were measured prior to HIV infection in cervicovaginal lavages from 58 HIV seroconverters and 58 matched uninfected controls and in plasma from a subset of 107 of these women from the Centre for the AIDS Programme of Research in South Africa 004 tenofovir gel trial. 25900168

2015

Entrez Id: 4153
Gene Symbol: MBL2
MBL2
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 GeneticVariation BEFREE The aim of this study was to determine whether genetic variants of MBL confer susceptibility to Pneumocystis pneumonia (PCP) in patients with advanced human immunodeficiency virus (HIV) infections. 26271591

2015

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 AlteredExpression BEFREE Aberrant antigen presentation by antigen-presenting cells (APCs) that exhibit increased B7-H1 expression and IL-10 production in HIV infection could be responsible for T-lymphocyte unresponsiveness and loss of protective immunity. 12468426

2003

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 AlteredExpression BEFREE "Tuberculosis in advanced HIV infection is associated with increased expression of IFNγ and its downstream targets". 29764370

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 AlteredExpression BEFREE HIV infection in ART-naïve women was associated with elevated breast milk levels of IP-10 and MIG, which areTh1-related cytokines induced by IFN-γ. 30359283

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 GeneticVariation BEFREE We measured T cell responsiveness by lymphoproliferation and interferon-gamma ELISPOT in a large cohort of HCV-infected individuals with and without HIV infection. 17194190

2006

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 AlteredExpression BEFREE Similarly, the CCR2b ligands MCP-1 and MCP-3 inhibit productive infection of PBMCs by both CCR5- and CXCR4-dependent strains of HIV-1, suggesting that expression of the MCP-1 chemokine may affect HIV infection via signaling through the CCR2 receptor and subsequent desensitization of the CCR5 and/or CXCR4 signaling pathway. 10497106

1999

Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 Biomarker BEFREE These data identify a novel miR-9/Blimp-1/IL-2 axis that is dysregulated in progressive HIV infection. 23129528

2013

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 GeneticVariation BEFREE Subset analyses of individuals with latent Mtb infection or without human immunodeficiency virus infection yielded higher heritability estimates, suggesting 10-30% of variation in IFN-γ is caused by a shared environment. 23629934

2013

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 GeneticVariation BEFREE Our findings indicate significant association of pro-inflammatory (IL2, IFN-γ, TNF-α) and anti-inflammatory cytokine gene variants (IL4, IL10) with the risk to acquire the HIV infection and development of AIDS related illness in Indian population. 31173933

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 Biomarker BEFREE Interleukin 10 responses are associated with sustained CD4 T-cell counts in treated HIV infection. 22693231

2012

Entrez Id: 3811
Gene Symbol: KIR3DL1
KIR3DL1
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 GeneticVariation BEFREE The current prospective cohort study evaluated whether variation in KIR genes is associated with HIV infection in discordant couples (DCs), where one spouse remains seronegative (HSN) despite repeated exposure to the HIV. 24877146

2014