Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Accumulation of mutant TP53 proteins in cancer cells has been recognized as an important factor that promotes cancer progression and metastasis. 24145670

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Additional molecular genetics alteration, including mutations of CTNNB1, PPP2R1A, and TP53, may contribute to tumor progression from EMC to UC. 24451280

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Gain-of-function of mutant p53: mutant p53 enhances cancer progression by inhibiting KLF17 expression in invasive breast carcinoma cells. 25111898

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE The roles of p53R2 in cancer progression based on the new function of mutant p53 and cytoplasmic p21. 24486301

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE This paper summarizes the role of two key mediators of cellular stress responses, namely p53 and HIF, which significantly affect cancer progression and compromise treatment outcomes. 23945296

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Understanding the mechanisms by which p53 loss and mutation promote tumor metastasis is crucial to understanding the biology of tumor progression and how to appropriately apply targeted therapies. 24658082

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Nevertheless, these modifications might alter MUT TP53 activity and contribute to a gain-of-function leading to increased metastasis and tumor progression. 24395704

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE TP53 mutants in the tower of babel of cancer progression. 24449472

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Loss of p53 attenuates the contribution of IL-6 deletion on suppressed tumor progression and extended survival in Kras-driven murine lung cancer. 24260500

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Taken together, our data provide an explanation to the observed high galectin-7 expression levels in cancer cells and suggest that galectin-7 could be part of a common pathway used by mutant p53 to promote cancer progression. 23967302

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE These findings indicate the role of miR-34a in tumor progression may be closely associated with p53 mutation and inversely correlated to Bcl-2 expression. 23529798

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Therefore, the binding of Mdm2 to the Slug mRNA appears to provide a novel mechanism through which Mdm2 promotes tumor progression in a manner independent of the presence of p53. 23438693

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE This compound binds to and abolishes the p53 protein, producing a genomic instability that promotes both the neoplastic progression and the hepatoma reprogramming. 23287475

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Thus, frequent loss or mutation of p53 may promote tumor progression by enhancing inflammation in the tumor microenvironment. 23300534

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE These data provide a novel understanding of the roles of p53 gain-of-function mutations in accelerating tumor progression and metastasis through modulation of the miR-130b-ZEB1 axis. 22847613

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Keratinocyte senescence acts as a barrier to tumor progression but appears to be lost in late pre-malignancy to yield genetically unstable oral squamous cell carcinomas (GU-OSCC); a subset of OSCC possessing wild-type p53 and are genetically stable (GS-OSCC). 23358854

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE NP-mediated p53 gene delivery slowed cancer progression and improved survival in an in vivo cancer model. 22595792

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE Recent findings demonstrated that HIPK2 inhibitions do exist in tumors and depend by several mechanisms including HIPK2 cytoplasmic localization, protein degradation, and loss of heterozygosity (LOH), recapitulating the biological outcome obtained by RNA interference studies in tumor cells, such as p53 inactivation, resistance to therapies, apoptosis inhibition, and tumor progression. 22889244

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE This study demonstrates a cooperative role for Pten and Tp53 suppression in complex karyotype sarcomas while establishing Notch as an important functional player in the cross talk of these pathways during tumor progression. 23708211

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE MYCN amplification and p53 inactivation are two typical characteristics of aggressive neuroblastomas and are strongly associated with cancer progression and treatment failure. 23443256

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE It has been well established that in addition to abrogating the tumor-suppressive function of wild-type p53, mutant p53 gains new functions and actively contributes to various stages of tumor progression. 23559009

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Inflammation-induced activation of proto-oncogenic NF-κB/REL and dysfunction of tumor suppressor TP53/p63/p73 family transcription factors are key events in cancer progression. 21933882

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Different missense mutations in p53 may confer unique activities and thereby offer insight into the mutagenic events that drive tumor progression. 22713868

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Loss of p53 or miR-34 contributed to neoplastic progression by triggering the Wnt-dependent, tissue-invasive activity of colorectal cancer cells. 22045851

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Dominant-negative (DN) p53 mutations in the tumor suppressor p53 gene partly contribute to human cancer progression by inactivating the remaining wild type allele. 21832879

2012