×
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
Leukemia, Myelocytic, Acute
1.000
Biomarker
CLINGEN
Interestingly, additional members in the families of both of these patients have been affected by AML , and the germline CEBPA mutations were also observed in these patients.
18768433 2008
×
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
Leukemia, Myelocytic, Acute
1.000
Biomarker
CLINGEN
Mutations in the CEBPA gene are present in 7%-10% of human patients with acute myeloid leukemia (AML ).
18394553 2008
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
Biomarker
CTD_human
Dual treatment with FLT3 inhibitor SU11657 and doxorubicin increases survival of leukemic mice.
17184839 2007
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
Biomarker
CTD_human
Flt3 internal tandem duplication (Flt3 -ITD) is a prevalent mutation in acute myeloid leukemia (AML ).17050201 2006
×
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
Leukemia, Myelocytic, Acute
1.000
Biomarker
CLINGEN
Further evidence that germline CEBPA mutations cause dominant inheritance of acute myeloid leukaemia .
15902292 2005
×
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
UNIPROT
CEBPA mutation is apparently the primary event in the development of AML in this family.15575056 2004
×
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
Leukemia, Myelocytic, Acute
1.000
Biomarker
CLINGEN
CEBPA mutation is apparently the primary event in the development of AML in this family.15575056 2004
×
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
UNIPROT
CEBPA mutation status was not demonstrated to be of prognostic importance in this patient group, although this may reflect the selection and size of the AML population studied.12661007 2003
×
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
UNIPROT
Ours is the first report of CEBPA mutations in human neoplasia, and such mutations are likely to induce the differentiation block found in AML .
11242107 2001
×
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
Leukemia, Myelocytic, Acute
1.000
Biomarker
CLINGEN
C/EBPalpha bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts.
10397723 1999
×
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
Leukemia, Myelocytic, Acute
1.000
Biomarker
CLINGEN
A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells.
1391942 1992
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CGI
×
Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CGI
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
UNIPROT
×
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
Leukemia, Myelocytic, Acute
0.800
Biomarker
CTD_human
Subtype-specific regulatory network rewiring in acute myeloid leukemia.
30420649 2019
×
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
Leukemia, Myelocytic, Acute
0.800
Biomarker
CTD_human
Dynamics of clonal evolution in myelodysplastic syndromes.
27992414 2017
×
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
Leukemia, Myelocytic, Acute
0.800
Biomarker
GENOMICS_ENGLAND
Genetic predisposition to hematologic malignancies: management and surveillance.
28600339 2017
×
Entrez Id: 2624
Gene Symbol: GATA2
GATA2
Leukemia, Myelocytic, Acute
0.800
Biomarker
GENOMICS_ENGLAND
Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients.
27418648 2016
×
Entrez Id: 2624
Gene Symbol: GATA2
GATA2
Leukemia, Myelocytic, Acute
0.800
Biomarker
GENOMICS_ENGLAND
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.
27069254 2016
×
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
Leukemia, Myelocytic, Acute
0.800
Biomarker
GENOMICS_ENGLAND
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.
27069254 2016
×
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
Leukemia, Myelocytic, Acute
0.800
Biomarker
CTD_human
Outside of signaling alterations, RUNX1 -RUNX1T1 and CBFB-MYH11 AML s demonstrated remarkably different spectra of cooperating mutations, as RUNX1 -RUNX1T1 cases harbored recurrent mutations in DHX15 and ZBTB7A, as well as an enrichment of mutations in epigenetic regulators, including ASXL2 and the cohesin complex.
27798625 2016
×
Entrez Id: 2624
Gene Symbol: GATA2
GATA2
Leukemia, Myelocytic, Acute
0.800
Biomarker
CTD_human
Our findings indicate that haploinsufficiency of GATA2 underlies primary lymphedema and predisposes to acute myeloid leukemia in this syndrome.
21892158 2011
×
Entrez Id: 2624
Gene Symbol: GATA2
GATA2
Leukemia, Myelocytic, Acute
0.800
Biomarker
GENOMICS_ENGLAND
We found the same, previously unidentified heterozygous c.1061C>T (p.Thr354Met) missense mutation in the GATA2 transcription factor gene segregating with the multigenerational transmission of MDS-AML in three families and a GATA2 c.1063_1065delACA (p.Thr355del) mutation at an adjacent codon in a fourth MDS family.
21892162 2011
×
Entrez Id: 2624
Gene Symbol: GATA2
GATA2
Leukemia, Myelocytic, Acute
0.800
Biomarker
CTD_human
We found the same, previously unidentified heterozygous c.1061C>T (p.Thr354Met) missense mutation in the GATA2 transcription factor gene segregating with the multigenerational transmission of MDS-AML in three families and a GATA2 c.1063_1065delACA (p.Thr355del) mutation at an adjacent codon in a fourth MDS family.
21892162 2011
×
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
Leukemia, Myelocytic, Acute
0.800
Biomarker
CTD_human
Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias.
18206229 2008