Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 AlteredExpression BEFREE Taken together, these results suggest that EGR-1 may stimulate prostate cancer cell growth through up-regulation of IGF-1R and indicate that down-regulation of EGR-1 could be an effective therapeutic approach against prostate cancer. 22115966

2012

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 Biomarker BEFREE Selected growth factor/growth factor receptor loops (mainly TGFα/EGFR and IGFs/IGFIR) have been proposed as regulators of prostate cancer cell growth. 21887406

2011

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 Biomarker BEFREE Plasma and tissue insulin-like growth factor-I receptor (IGF-IR) as a prognostic marker for prostate cancer and anti-IGF-IR agents as novel therapeutic strategy for refractory cases: a review. 21782884

2011

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 AlteredExpression BEFREE In addition, lycopene treatment enhanced the growth-inhibitory effect of docetaxel more effectively on DU145 cells with IGF-IR high expression than on those PCa cell lines with IGF-IR low expression. 21403837

2011

Entrez Id: 4316
Gene Symbol: MMP7
MMP7
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 GeneticVariation BEFREE The matrix metalloproteinase-7 polymorphism rs10895304 is associated with increased recurrence risk in patients with clinically localized prostate cancer. 20605361

2011

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 AlteredExpression BEFREE Our results suggest that prostate cancer progression is associated with a decrease in IGF-IR expression that could be the result of impaired ability of AR to stimulate IGF-IR gene expression. 20417685

2010

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 PosttranslationalModification BEFREE The methylation status of the AR and IGF1R genes was evaluated in a series of prostate cancer cell lines corresponding to early (benign) and advanced (metastatic) stages of the disease. 20338164

2010

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 Biomarker BEFREE Antisense oligonucleotide targeting of insulin-like growth factor-1 receptor (IGF-1R) in prostate cancer. 19790231

2010

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 AlteredExpression BEFREE Analysis of information from public gene expression databases confirmed that co-expression of insulin receptor mRNA and IGF-I receptor mRNA is common in prostate cancer specimens. 18785179

2009

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 Biomarker BEFREE Apigenin suppresses insulin-like growth factor I receptor signaling in human prostate cancer: an in vitro and in vivo study. 18726972

2009

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 AlteredExpression BEFREE Insulin-like growth factor-I receptor (IGF-IR) overexpression may play a role in prostate cancer progression. 19738069

2009

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 AlteredExpression BEFREE In addition, an inverse correlation between BRCA1 and IGF-IR levels was observed in the androgen receptor (AR)-negative prostate cancer-derived P69 and M12 cell lines. 19223505

2009

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 Biomarker RGD Disruption of growth hormone signaling retards prostate carcinogenesis in the Probasin/TAg rat. 18079205

2008

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 Biomarker BEFREE In human PCa, the lowest IGF-IR immunoreactivity group tended to have the lowest body mass index in both normal and PCa epithelium. 18175332

2008

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 Biomarker BEFREE Our results suggest statins are potent inhibitors of the IGF-1/IGF-1R system in prostate cancer cells and may be beneficial in prostate cancer treatment. 18489904

2008

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 Biomarker BEFREE Inhibition of the IGF-IR or the Src-ERK pathway should be considered, therefore, as an adjuvant therapy in prostate cancer. 17875736

2007

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 AlteredExpression BEFREE Luteolin inhibited insulin-like growth factor 1 (IGF-1) induced activation of IGF-1R and AKT in prostate cancer PC-3 and DU145 cells. 17065200

2007

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 Biomarker BEFREE We previously showed that IGF1R knockdown blocked survival of prostate cancer cells in which Akt activation was deregulated by PTEN loss. 16715137

2006

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 GeneticVariation BEFREE Our observation that men who do not carry two copies of the IGF-IR (AGG)7 allele are at increased risk of prostate cancer merits further investigation. 17164371

2006

Entrez Id: 4316
Gene Symbol: MMP7
MMP7
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 AlteredExpression BEFREE Whereas MMP-1 was overexpressed in NAP epithelial glands and progressively decreased from PIN to CaP, MMP-7, MMP-9 and MT1-MMP were more strongly expressed in CaP than in PIN and NAP tissue. 16619495

2006

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 Biomarker BEFREE These results support the concept of IGF1R targeting in prostate cancer, and indicate that PTEN loss does not render tumor cells refractory to this strategy. 15499378

2005

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 AlteredExpression BEFREE In this study, we show that androgens up-regulate insulin-like growth factor-I receptor (IGF-IR) expression and sensitize prostate cancer cells to the biological effects of IGF-I. 15753383

2005

Entrez Id: 4316
Gene Symbol: MMP7
MMP7
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 Biomarker BEFREE This study suggests that inhibition of MMP-7 will have therapeutic benefit in the treatment of prostate cancer-induced osteolysis. 15894268

2005

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 AlteredExpression BEFREE Increased insulin-like growth factor I receptor expression and signaling are components of androgen-independent progression in a lineage-derived prostate cancer progression model. 15574769

2004

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.300 AlteredExpression BEFREE IGF1R is overexpressed by prostate cancer compared with benign prostatic epithelium and IGF1R expression commonly persists in androgen-independent metastatic disease at levels comparable to those in the primary. 12581018

2003