Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
CUI: C0023418
Disease: leukemia
leukemia 		0.400 GeneticVariation BEFREE Shp2 mutations might also contribute to the pathogenesis of some leukemias. 12826400

2003
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
CUI: C0023418
Disease: leukemia
leukemia 		0.400 GeneticVariation BEFREE She provides an overview of leukemias that are common in pediatric malignancies but rarely observed in adults, including the TEL-AML1 (ETV6-RUNX1) fusion associated with pediatric B-cell ALL, the OTT-MAL fusion associated with infant megakaryoblastic leukemia, PTPN11 mutations in juvenile myelomonocytic leukemia, and MLL fusion genes in leukemogenesis, among others. 15561678

2004
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
CUI: C0023418
Disease: leukemia
leukemia 		0.400 GeneticVariation BEFREE We now know that at least one other PTP, the SH2 domain-containing phosphatase Shp2, is a bona fide oncogene that is mutated in several types of leukemia and hyperactivated by other mechanisms in some solid tumors. 17227708

2007