DisGeNET - a database of gene-disease associations

Source: BEFREE

Disease: Malignant neoplasm of ovary ×

Gene: MSLN ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Disease

Score _gda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	10232
Gene Symbol:	MSLN

MSLN

CUI:	C1140680
Disease:	Malignant neoplasm of ovary

Malignant neoplasm of ovary

0.400

Biomarker

BEFREE

In addition, Mesothelin-GITR-CD3 CAR-T cells also killed mesothelin-positive ovarian cancer cell lines, and pancreatic cancer cells.

29772559

2018

Entrez Id:	10232
Gene Symbol:	MSLN

MSLN

CUI:	C1140680
Disease:	Malignant neoplasm of ovary

Malignant neoplasm of ovary

0.400

Biomarker

BEFREE

Analogous to mesothelioma and ovarian carcinoma, a significant increase of MSLN was detected in plasma from patients with hydrosalpinx.

31222072

2019

Entrez Id:	10232
Gene Symbol:	MSLN

MSLN

CUI:	C1140680
Disease:	Malignant neoplasm of ovary

Malignant neoplasm of ovary

0.400

AlteredExpression

BEFREE

High expression of mesothelin in advanced serous ovarian cancer is associated with poor prognosis.

31646807

2020