Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0018203
Disease: Chronic granulomatous disease
Chronic granulomatous disease 		0.100 Biomarker BEFREE In summary, both CGD patients and CGD mice have an altered IgG subtype distribution, which is associated with an increased IFNγ production. 30050527

2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0018203
Disease: Chronic granulomatous disease
Chronic granulomatous disease 		0.100 Biomarker BEFREE In particular, differential exon expression of WARS (encoding tryptophanyl-transfer RNA synthetase, which has an essential function in protein synthesis) induced by IFN-γ in normal and CGD cells suggests that this gene may have an important contribution to the benefits of IFN-γ treatment for CGD. 30260027

2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0018203
Disease: Chronic granulomatous disease
Chronic granulomatous disease 		0.100 Biomarker BEFREE IFN-γ therapy has been approved by the Food and Drug Administration (FDA) for the treatment of chronic granulomatous disease and severe malignant osteopetrosis. 31233057

2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0018203
Disease: Chronic granulomatous disease
Chronic granulomatous disease 		0.100 Biomarker BEFREE Actimmune<sup>®</sup> is a US Food and Drug Administration (FDA) approved version of IFN γ for the indication of reducing infections associated with chronic granulomatous disease and severe malignant osteopetrosis. 31446487

2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0018203
Disease: Chronic granulomatous disease
Chronic granulomatous disease 		0.100 AlteredExpression BEFREE Our results suggest a paracrine signaling loop between M1 macrophage derived IL-18 and non-macrophage derived IFN-γ maintaining macrophage pro-inflammatory activity in CGD tissue. 31681257

2019