Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0018203
Disease: Chronic granulomatous disease
Chronic granulomatous disease 		0.100 Biomarker BEFREE This work expands the genetic spectrum of X-linked CGD and demonstrates improvement in macrophage function in X91<sup>+</sup>CGD patient by rhIFN-γ. 27666509

2016
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0018203
Disease: Chronic granulomatous disease
Chronic granulomatous disease 		0.100 Biomarker BEFREE This study demonstrates partial correction of the cellular defects in chronic granulomatous disease by interferon gamma and provides a basis for clinical trials of the agent. 2838754

1988
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0018203
Disease: Chronic granulomatous disease
Chronic granulomatous disease 		0.100 Biomarker BEFREE During the international placebo-controlled trial on the efficacy of interferon-gamma (IFN-gamma) in chronic granulomatous disease (CGD), 19 patients entered the study via our Institute. 8975873

1996
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0018203
Disease: Chronic granulomatous disease
Chronic granulomatous disease 		0.100 AlteredExpression BEFREE Here, we show that IFNγ induces normal levels of kynurenine in cultures of O(2)(·)-deficient monocytes, dendritic cells, and polymorphonuclear leukocytes from gp91(PHOX)- or p47(PHOX)-deficient human CGD donors. 20511543

2010
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0018203
Disease: Chronic granulomatous disease
Chronic granulomatous disease 		0.100 AlteredExpression BEFREE Our results suggest a paracrine signaling loop between M1 macrophage derived IL-18 and non-macrophage derived IFN-γ maintaining macrophage pro-inflammatory activity in CGD tissue. 31681257

2019