Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0028754
Disease: Obesity
Obesity 		0.900 Biomarker GENOMICS_ENGLAND

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0028754
Disease: Obesity
Obesity 		0.900 Biomarker GENOMICS_ENGLAND

Entrez Id: 1363
Gene Symbol: CPE
CPE
CUI: C0028754
Disease: Obesity
Obesity 		0.730 Biomarker CTD_human Augmented pulmonary responses to acute ozone exposure in obese mice: roles of TNFR2 and IL-13. 23434795

2013
Entrez Id: 1363
Gene Symbol: CPE
CPE
CUI: C0028754
Disease: Obesity
Obesity 		0.730 Biomarker GENOMICS_ENGLAND The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits. 15358678

2004
Entrez Id: 1363
Gene Symbol: CPE
CPE
CUI: C0028754
Disease: Obesity
Obesity 		0.730 Biomarker CTD_human The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits. 15358678

2004
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Elevated pulmonary arterial pressure in Zucker diabetic fatty rats. 30689673

2019
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat. 29743445

2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Therapeutic CTD_human Retinoic acid receptor-related orphan receptor α stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress. 28698385

2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Retinoic acid receptor-related orphan receptor α stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress. 28698385

2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Stevia-derived compounds attenuate the toxic effects of ectopic lipid accumulation in the liver of obese mice: a transcriptomic and metabolomic study. 25554529

2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Therapeutic CTD_human Biologically inactive leptin and early-onset extreme obesity. 25551525

2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Therapeutic CTD_human Stevia-derived compounds attenuate the toxic effects of ectopic lipid accumulation in the liver of obese mice: a transcriptomic and metabolomic study. 25554529

2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Biologically inactive leptin and early-onset extreme obesity. 25551525

2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Therapeutic CTD_human Sequencing of the leptin gene may need to be considered in hyperphagic, severely obese children with detectable levels of circulating leptin. 26186301

2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Sequencing of the leptin gene may need to be considered in hyperphagic, severely obese children with detectable levels of circulating leptin. 26186301

2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Therapeutic CTD_human Oral administration of Nitraria retusa ethanolic extract enhances hepatic lipid metabolism in db/db mice model 'BKS.Cg-Dock7(m)+/+ Lepr(db/)J' through the modulation of lipogenesis-lipolysis balance. 25086370

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. 23839791

2014
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Exposure to a northern contaminant mixture (NCM) alters hepatic energy and lipid metabolism exacerbating hepatic steatosis in obese JCR rats. 25222487

2014
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Heat shock protein 70 is necessary to improve mitochondrial bioenergetics and reverse diabetic sensory neuropathy following KU-32 therapy. 24263156

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Therapeutic CTD_human Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. 23839791

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Oral administration of Nitraria retusa ethanolic extract enhances hepatic lipid metabolism in db/db mice model 'BKS.Cg-Dock7(m)+/+ Lepr(db/)J' through the modulation of lipogenesis-lipolysis balance. 25086370

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Therapeutic CTD_human The effect of endurance exercise on both skeletal muscle and systemic oxidative stress in previously sedentary obese men. 24042701

2013
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Evaluation of 29 SNPs (P < 1 × 10(-5)) in an additional 971 severely obese children and 1,990 controls identified 4 new loci associated with severe obesity (LEPR, PRKCH, PACS1 and RMST). 23563609

2013
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human The effect of endurance exercise on both skeletal muscle and systemic oxidative stress in previously sedentary obese men. 24042701

2013
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker CTD_human Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity. 22276206

2012